scholarly journals Homeostatic Regulation of Neuronal Excitability

Scholarpedia ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. 1656 ◽  
Author(s):  
Alex Williams ◽  
Timothy O'Leary ◽  
Eve Marder
Keyword(s):  
Neuronal Excitability ◽  
Homeostatic Regulation

Homeostatic regulation of neuronal excitability by probiotics in male germ‐free mice

2021 ◽  
Author(s):  
Juhyun Kim ◽  
Dong Won Kim ◽  
Adrian Lee ◽  
Madisen Mason ◽  
Yan Jouroukhin ◽  
...  
Keyword(s):  
Neuronal Excitability ◽  
Homeostatic Regulation ◽  
Germ Free

Dorsal Horn Pain Mechanisms

2019 ◽  
pp. 444-469 ◽  
Author(s):  
Hanns Ulrich Zeilhofer ◽  
Robert Ganley
Keyword(s):  
Dorsal Horn ◽  
Neuronal Excitability ◽  
Functional Organization ◽  
Synaptic Integration ◽  
Synaptic Efficacy ◽  
Pain Mechanisms ◽  
Pain Pathway ◽  
Pathological Pain ◽  
The Subject ◽  
Equivalent Structure

The spinal dorsal horn and its equivalent structure in the brainstem constitute the first sites of synaptic integration in the pain pathway. A huge body of literature exists on alterations in spinal nociceptive signal processing that contribute to the generation of exaggerated pain states and hence to what is generally known as “central sensitization.” Such mechanisms include changes in synaptic efficacy or neuronal excitability, which can be evoked by intense nociceptive stimulation or by inflammatory or neuropathic insults. Some of these changes cause alterations in the functional organization of dorsal horn sensory circuits, leading to abnormal pathological pain sensations. This article reviews the present state of this knowledge. It does not cover the contributions of astrocytes and microglia in detail as their functions are the subject of a separate chapter.

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