Higher efficacy of pre-hospital tirofiban with longer pre-treatment time to primary PCI: protection for the negative impact of time delay

2011 ◽  
Vol 7 (4) ◽  
pp. 442-448 ◽  
Author(s):  
Ton Heestermans ◽  
Menko-Jan de Boer ◽  
Jochem W. van Werkum ◽  
Arend Mosterd ◽  
A.T. Marcel Gosselink ◽  
...  
Keyword(s):  
Time Delay ◽  
Treatment Time ◽  
Negative Impact ◽  
Primary Pci ◽  
Pre Treatment

scholarly journals Investigation of Dye Removal Capability of Blast Furnace Slag in Wastewater Treatment

2021 ◽  
Vol 13 (4) ◽  
pp. 1970
Author(s):  
Sara Yasipourtehrani ◽  
Vladimir Strezov ◽  
Tao Kan ◽  
Tim Evans
Keyword(s):  
Blast Furnace ◽  
Blast Furnace Slag ◽  
Industrial Wastewater ◽  
Dye Removal ◽  
Treatment Time ◽  
Activated Carbons ◽  
Industrial Applications ◽  
Ore Processing ◽  
Pre Treatment ◽  
Furnace Slag

Blast Furnace Slag (BFS) is a by-product of the iron ore processing industry with potential to be used in different industrial applications. In this research, BFS was used to examine its ability for dye removal from wastewater. The efficiency of two types of BFS samples for removal of cationic methylene blue (MB) and acidic methyl orange (MO) dyes was investigated and results found that the optimal conditions for treatment of wastewater were 80 g/L of adsorbent dose and 1 h of treatment time for both dyes. BFS was found to be more effective for removal of the acidic MO dye than the cationic MB dye. Under shorter residence times, the results showed reverse trends with BFS samples removing higher concentrations of MB than MO. The BFS chemistry had additional impacts on the efficiency of dye removal. Higher basicity of BFS had lower dye removal ability for adsorption of acidic dye when applied at smaller concentrations, while for cationic dye when applied at higher concentrations. The results showed that BFS has potential role for pre-treatment of industrial wastewater contaminated with dyes and may contribute to reduced use of more expensive adsorbents, such as activated carbons.

The Systematic Development of Attributes And Levels For A Discrete Choice Experiment of HIV Patient Preferences For Long-Acting Antiretroviral Therapies In The United States

2021 ◽  
Author(s):  
Aaron T. Brah ◽  
Douglas Barthold ◽  
Brett Hauber ◽  
Ann C. Collier ◽  
Rodney J.Y. Ho ◽  
...  
Keyword(s):  
Discrete Choice Experiment ◽  
Discrete Choice ◽  
Patient Preferences ◽  
Choice Experiment ◽  
Treatment Time ◽  
Negative Reaction ◽  
Antiretroviral Therapies ◽  
Key Informant ◽  
Pre Treatment ◽  
Long Acting

Abstract Introduction: Patient preferences for long-acting antiretroviral therapies (LA-ART) should inform development of regimens with optimal adherence and acceptability. We describe a systematic process used to identify attributes and levels for a discrete choice experiment (DCE) designed to elicit preferences for potential LA-ART options in the US. Methods: Our approach was conducted in four stages: data collection, data reduction, removing inappropriate attributes, and optimizing wording. We started with 8 attributes defining potential LA-ART products based on existing literature and knowledge of products in development. We conducted 12 key informant interviews with experts in HIV treatment. The list of attributes, the set of plausible levels for each attribute, and restrictions on combinations of attribute levels were updated iteratively.Results: Despite uncertainty about which products will become available, key informant discussions converged on 4 delivery modes (infusions and patches were not considered immediately feasible) and 6 additional attributes. Treatment effectiveness and frequency of clinical monitoring were dropped. Oral lead-in therapy was split into two attributes: pre-treatment time undetectable and pre-treatment negative reaction testing. We omitted product-specific systemic and local side effects. In addition to mode, the final set of attributes included: frequency of dosing; location of treatment; pain; pre-treatment time undetectable; pre-treatment negative reaction testing; and late-dose leeway.Conclusions: A systematic process successfully captured elements that are both feasible and relevant to evaluating the acceptability of potential LA-ART alternatives to patients.

The prevalence and management of patients with hypodontia: A cross -sectional study

2021 ◽  
pp. 146531252110654
Author(s):  
Nusaybah Elsherif ◽  
Jose Rodriguez ◽  
Farooq Ahmed
Keyword(s):  
Orthodontic Treatment ◽  
Negative Impact ◽  
Cross Sectional Study ◽  
Class I ◽  
Class Iii ◽  
Dental Anomalies ◽  
Missing Teeth ◽  
Cross Sectional ◽  
Related Quality ◽  
Pre Treatment

Background: Hypodontia is one of the most common anomalies in dentistry. Hypodontia has a negative impact on oral health-related quality of life with patients best seen in a multidisciplinary clinic to improve treatment outcomes. Aim: To investigate the prevalence of hypodontia and its association with other dental anomalies, as well as malocclusion, and to investigate the treatment planned for patients attending the clinic and whether the type of missing teeth affected the proposed treatment. Materials and Methods: Analysis of consecutive patients attending the hypodontia clinic at a dental hospital between February and November 2020. A total of 100 patients who met the inclusion criteria were identified. Data collected included the following: age/sex; number and type of missing teeth; pre-treatment occlusion; presence of other dental anomalies; and planned treatment. Results: A total of 100 patients (55% female; age range = 7–41 years; mean age = 18 years) were included. Of the cohort, 47% had a class I skeletal relationship and participants were significantly less likely to have a class III skeletal or incisor relationship; 45% had another dental anomaly with the most common being microdontia. Space opening was the preferred treatment option for those managed by orthodontic treatment with resin-bonded bridges most likely to be used for restoration of spaces, 86%. Conclusion: Lower second premolars were the most commonly missing teeth. Participants were significantly less likely to have a class III incisor or skeletal relationship than class I or II. Space opening was the favoured approach for orthodontic treatment, particularly for maxillary lateral incisors.

scholarly journals The Impact of Orthodontic Treatment on Pre-Existing Gingival Recessions: A Retrospective Study

2021 ◽  
Vol 11 (19) ◽  
pp. 9036
Author(s):  
Guostė Antanavičienė ◽  
Eglė Zasčiurinskienė ◽  
Dalia Smailienė ◽  
Nomeda Basevičienė
Keyword(s):  
Retrospective Study ◽  
Orthodontic Treatment ◽  
Negative Impact ◽  
Open Bite ◽  
Class Iii ◽  
Before And After ◽  
Pre Treatment ◽  
Mandibular Teeth ◽  
The Impact ◽  
Plaster Models

(1) Background: This retrospective study aimed to examine the change of gingival recessions (GR) before and after orthodontic treatment (OT). (2) Methods: Patients who had at least one GR on the vestibular surface of maxillary/mandibular teeth mesial to first molars were included. GR was measured on good quality plaster models before and after OT. (3) Results: Significant improvement of mean GR at patient level was found between T0 and T1 (0.45 mm, 95% CI: 0.28, 0.62) (p < 0.001). In 51.4% of patients GRs became better, in 37.8% GRs did not change. and in 10.8% GRs became worse. At tooth level the mean GR improvement was 0.54 mm (CI: 0.42, 0.65; median 0.55 mm Q1; Q3: 0.12, 0.96) (p < 0.001). GR improved in 67 teeth (58.7%), did not change in 41 (36.0%), and worsened in 6 (5.3%). Full healing was observed in 15 teeth. A reduced GR improvement was found in cases with pre-treatment open bite (OR 3.89; CI: 1.35, 11.16; p = 0.008) and dental Class III patients (OR 2.6; CI: 1.11, 6.0; p = 0.026). (4) Conclusion: There was an improvement of GR after OT in more than half of the patients. Class III malocclusion and reduced pre-treatment overbite had a negative impact on GR improvement.

The Optimization of Thermal Pre-Treatment Time for Extracellular Polymeric Substances Extraction from Sewage Sludge

2015 ◽  
Vol 768 ◽  
pp. 496-505 ◽  
Author(s):  
Yu Yi Zheng ◽  
Hong Lin ◽  
Zhi Long Lin ◽  
Yi Fang Zeng ◽  
Yu Fang Yu ◽  
...  
Keyword(s):  
Experimental Data ◽  
Sewage Sludge ◽  
Process Model ◽  
Extracellular Polymeric Substances ◽  
Treatment Time ◽  
Soluble Sugar ◽  
Analytic Hierarchy ◽  
Pre Treatment ◽  
Hierarchy Process ◽  
Optimum Extraction

This study aims to find out the optimum extraction time varied from 5 min to 60 min for extracellular polymeric substances (EPS) from sewage sludge pretreated at 80 °C. The change of the contents of EPS and its components under different time limit were recorded and compared. The results showed: the contents of soluble protein, TOC, soluble sugar and DNA was increased by 579.17 mg/l, 514.25 mg/l, 132.79 mg/l, and 34.69 mg/l, respectively, with the increase of thermal pre-treatment time during the process, and the DNA content increased the least, which indicating that the effect of thermal pre-treatment at 80 °C on cell lysis of sewage sludge was small. The EPS content, as a whole, was increased with the increase of thermal pre-treatment time. By analyzing the experimental data with the Analytic Hierarchy Process Model, which was used to identify the optimum thermal pre-treatment time of extracting EPS, the results showed that the effectiveness of EPS extraction from sludges was 30 min>60 min>50 min>20 min>40 min>10 min>5 min. Therefore, the 30 min was choosed as the optimum thermal pre-treatment time.

Abstract 11: Comparison Of Various Methods Of Assessment Of Intracranial Collaterals On The Pretreatment Ct-angiograms To Predict Outcomes In Acute Anterior Circulation Ischemic Stroke

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
leonard L yeo ◽  
benjamin wakerley ◽  
Aftab Ahmad ◽  
prakash Paliwal ◽  
kay ng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Outcome ◽  
Functional Outcomes ◽  
Treatment Time ◽  
Scoring Systems ◽  
Anterior Circulation ◽  
Unaffected Side ◽  
Computed Tomographic ◽  
Pre Treatment ◽  
Iv Tpa

Background: The presence of effective collateral blood flow patterns may influence response to intravenously administered tissue plasminogen activator (IV-tPA) in acute ischemic stroke (AIS). We compared various existing methods of scoring collaterals on the pre-treatment computed tomographic angiogram (CTA) of the brain for a reliable prediction of functional outcome in AIS patients. Methods: Consecutive AIS patients treated with IV-tPA within 4.5 hours of symptom-onset during 2007-2011 were included. Data were collected for demographics, vascular risk factors, National Institute of Health Stroke Scale (NIHSS) scores and stroke subtypes. Intracranial collaterals were evaluated by 2 independent blinded neuroradiologists via 4 predefined criteria- Miteff’s system that grades middle cerebral artery (MCA) collateral branches with respect to the sylvian fissure; Maas system that compares collaterals on the affected hemisphere against the unaffected side; modified Tan’s scale where collaterals in 50% or more of the MCA territory are classified as good; and a 20-point collateral grading scale in regions corresponding to Alberta Stroke Program Early CT score (ASPECTS) methodology. Good functional outcomes at 3-months were determined by modified Rankin scale (mRS) scores of 0-1. Results: CTA was performed in 115 patients with anterior circulation AIS before IV-tPA bolus. Median age 66yrs (range 35-92), 42% males, median NIHSS 19 points (range 3-30) and median onset-to-treatment time 155 minutes. Overall, 52 (45.2%) patients achieved good functional outcome at 3-months. Univariable analysis revealed younger age, absence of diabetes, lower pre-tPA NIHSS scores and good collaterals according to ASPECTS methodology as significantly associated with good functional outcomes. On multivariable logistic regression, only lower NIHSS (OR 1.111 per NIHSS point; 95% CI 1.023-1.206, p=0.013) and good collaterals by ASPECTS methodology (OR 1.117 per point; 95%CI 1.006-1.241, p=0.039) were found as independent predictors of good outcomes. Conclusion: Of the existing intracranial collaterals scoring systems, only the ASPECTS methodology serves as a reliable predictor of favorable outcomes at 3-months in patients with anterior circulation AIS.

P950Synergistic impact of renal failure and left ventricular dysfunction on short- and long-term mortality in patients with STEMI undergoing primary PCI

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A S Pavlovic ◽  
D Milasinovic ◽  
Z Mehmedbegovic ◽  
V Dedovic ◽  
D Jelic ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cox Regression ◽  
Negative Impact ◽  
Reference Group ◽  
Left Ventricular ◽  
Primary Pci ◽  
Catheterization Laboratory ◽  
Lv Dysfunction ◽  
Risk Of Mortality ◽  
Increased Risk

Abstract Background Impaired left ventricular function (LV) and renal failure (RF) have both been separately associated with increased risk of mortality in ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Purpose Our aim was to comparatively evaluate the relative impact of LV dysfunction and renal failure (RF) on the risk of mortality in primary PCI-treated STEMI patients. Methods 5878 patients admitted for primary PCI during 2009–2015, from a prospectively kept, electronic registry of a high-volume catheterization laboratory, were included in the analysis. LV dysfunction was defined as EF<40%, and RF as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 according to Cockcroft-Gault formula. Adjusted Cox regression models were used to assess 30-day and 3-year mortality hazard, with patients with EF≥40% and normal renal function serving as the reference group. Results RF was documented in 17.1% (n=1006), whereas 36.5% had LV dysfunction (n=2141). LV dysfunction and RF were separately associated with increased crude mortality rates, whereas the concurrence of both resulted in the highest mortality rate at 30 days (0.7% if no RF and normal EF vs. 5.4% if RF alone vs. 3.9% if EF<40% alone vs. 12.6% if both RF and EF<40%; p<0.001), and at 3 years (5.7% if no RF and normal EF vs. 29.0% if RF alone vs. 19.0% if EF<40% alone vs. 47.4% if both RF and EF<40%; p<0.001). After multivariable adjustment for other significant mortality predictors, such as age, previous stroke, diabetes, hyperlipidemia, anemia and Killip≥2, RF and LV dysfunction were associated with a comparable increase in mortality risk at 30 days (HR=4.1 and HR=3.7, respectively, p<0.001 for both) and at 3 years (HR=2.8 and HR=2.7, respectively, p<0.001 for both). Importantly, the combined presence of RF and low EF was independently associated with a marked increase in both 30- day (HR=6.5, 95% CI 3.7–11.4, p<0.001), and 3-year mortality (HR=4.3, 95% CI 3.3–5.6, p<0.001). Kaplan Meier cumulative mortality curves Conclusion Apart from each being independently associated with an increased risk of mortality, the concurrence of renal failure and LV dysfunction had a synergistic negative impact on the prognosis of primary PCI-treated STEMI patients

scholarly journals Enhancement of flaky graphite cleaning by ultrasonic treatment

2019 ◽  
Vol 6 (12) ◽  
pp. 191160 ◽  
Author(s):  
Wenze Kang ◽  
Huijian Li
Keyword(s):  
Carbon Content ◽  
Ultrasonic Treatment ◽  
Treatment Time ◽  
Treatment Technique ◽  
Particle Sizes ◽  
Cleaning Process ◽  
Flotation Concentrate ◽  
Metal Impurities ◽  
Pre Treatment ◽  
Ultrasound Power

In this study, the aim is to simplify the graphite cleaning process. In order to achieve flotation for graphite effectively, ultrasonic treatment was used as a pre-treatment technique. Flotation tests were conducted using different ultrasound power and ultrasonic treatment time. The influences of ultrasonic treatment on particle sizes, morphologies, wettability, the content of surface elements and on the flotation effect of flaky graphite were investigated. The results of ultrasonic treatment for graphite flotation were compared with the results of conventional flotation. The results showed that ultrasonic treatment not only changed the size of flaky graphite, but also eliminated impurities on the graphite surface. Additionally, the ultrasonic treatment improved the hydrophobicity of graphite. It was observed that ultrasound can remove not only silicate impurities but also most other metal impurities. The yield, carbon content and recovery of flotation concentrate were 91.46%, 95.17% and 96.12% after ultrasonic treatment for 4 min with ultrasound power 1600 W, which were 5.83%, 2.86% and 8.84% higher than that of conventional flotation, respectively. The graphite after ultrasonic treatment was conducted only one times flotation, the carbon content in concentrate products had reached 95%. This study indicates that intensifying graphite flotation by ultrasonic treatment can shorten the graphite cleaning process.

Conhecimento e Práticas Maternas e Condições de Saúde Bucal de Crianças Assistidas em Uma Unidade Básica de Saúde de um Município no Sul do Brasil

UNICIÊNCIAS ◽  
2018 ◽  
Vol 22 (2) ◽  
pp. 92
Author(s):  
Karina Semencio Avelino ◽  
Ilma Carla de Souza Porcelli ◽  
Valéria Campos Mariano Francelino ◽  
Ermelinda Matsuura ◽  
Nathalia Maciel Corsi ◽  
...  
Keyword(s):  
Public Health ◽  
Oral Health ◽  
Dental Caries ◽  
Dental Care ◽  
Family Income ◽  
Treatment Time ◽  
Negative Impact ◽  
Health Network ◽  
The Public ◽  
Level Of Knowledge

A cárie precoce repercute, negativamente, na vida da criança. Este estudo avaliou o nível de conhecimento, práticas maternas e o padrão de saúde bucal de crianças assistidas pela rede pública de saúde de um município do Sul do Brasil. Foram analisados 279 prontuários de crianças que estavam sendo atendidas na clínica de bebê de uma Unidade Básica de Saúde. O conhecimento, as práticas nos cuidados com a saúde bucal infantil e o perfil sócio demográfico das famílias foram identificados em entrevistas realizadas com as mães no início do atendimento. Verificou-se os procedimentos clínicos-preventivos realizados, número de consultas e faltas e se avaliou a condição de saúde bucal da criança na última consulta. Foram aplicados os testes Mann-Whitney e Kruskal-Wallis, fixando-se o nível de significância em 5%. As mães apresentaram um conhecimento razoável, porém suas práticas, principalmente, com cuidados alimentares das crianças eram precárias. Procedimentos preventivos predominaram na atenção odontológica oferecida, contudo, 20,8% das crianças desenvolveram cárie dentária, sendo o índice ceo-d médio igual a 0,53 (DP=1,35). A maior severidade de cárie se associou à maior idade da criança (<0,001) e da mãe (p=0,006), menor renda familiar (0.036), maior tempo de tratamento (<0,001) e maior número de faltas às consultas (<0,001). A atenção odontológica é importante a partir do primeiro ano de vida, assim como as ações em saúde bucal, com atividades educativas direcionadas aos programas pré-natais, além do desenvolvimento de estratégias para aumentar a adesão das mães/ crianças aos programas promocionais em saúde bucal que são oferecidos pela rede pública de saúde. Palavras-chave: Criança. Saúde Bucal. Mães. Cárie Dentária. Conhecimento. AbstractEarly caries has a negative impact on the child's life. This study evaluated the level of knowledge, maternal practices and oral health pattern of children assisted by the public health network of a municipality in the south of Brazil. Information was analyzed from 279 medical records of children treated at the baby clinic of a Basic-Health-Unit. The knowledge, practices in care of children's oral health and sociodemographic profile of families were identified in interviews with mothers at the beginning of care. The clinical-preventive procedures performed, number of consultations, absences were checked and the child's oral health condition was evaluated at the last visit. The Mann-Whitney and Kruskal-Wallis tests were applied, setting the level of significance at 5%. The mothers presented a reasonable level of knowledge, however, their practices,particularly those about care related to feeding their children were precarious. Preventive procedures predominated the offered dental care, however, 20.8% of the children developed dental caries - mean dmf-t index 0.53 (SD = 1.35). The highest level of caries severity was associated with the highest age of both the child (<0.001) and mother (p = 0.006), lower family income (0.036), longer treatment time (<0.001) and higher number absences to the appointments. Dental care is important from the first year of life onwards, as well as oral health actions, with educational activities directed towards prenatal programs and the development of strategies to increase the adherence of mothers /children to the promotional programs offered by the public health network. Keywords: Child. Oral health. Mothers. Dental Caries. Knowledge. 

MONITORING OF ENTOMOСOMPLEXES OF SOFT SPRING WHEAT IN THE FOREST-STEPPE OF SAMARA AREA

2016 ◽  
Vol 1 (4) ◽  
pp. 3-9
Author(s):  
Каплин ◽  
Vladimir Kaplin
Keyword(s):  
Seedling Growth ◽  
Spring Wheat ◽  
Negative Impact ◽  
Stem Elongation ◽  
High Density ◽  
Forest Steppe ◽  
Cereal Aphids ◽  
Competitive Relations ◽  
Hippodamia Variegata ◽  
Pre Treatment

The purpose of research is creation of conditions for the formation of self-regulating entomocomplexes in agrocenoses with a significant competitive relations in the cultivation of spring wheat in the non-use of insecticides against pests. Insects was collected with an entomological net for 25-50 flaps in triple repeated in period of vegetation of wheat. In the conditions of the non-use of insecticides of entomokomplexes included insects-phytophagous which are potential vectors of viruses, phytoplasmas; suctorial and gnawing phytofagous; insects are developing inwardly wheat stems; entomophagous. Entomophagous regulating the density of phytophagous were represented by predators and parasites. In 2013-2016 Phyllotreta vittula, Oscinella pusilla, O. frit had a high density in the stage of seedling growth, Haplothrips tritici – in the stage of stem elongation of spring wheat. Against pests of seedlings in terms of their high density recommended for pre-treatment of seeds of spring wheat before sowing by system insecticide Cruiser, KC, without a negative impact on useful entomofauna of the agro-ecosystems. To the head emergence stage of spring wheat and the beginning of oviposition of Haplothrips tritici, its population was effectively reduced by Aeolothrips pascidutus. Development of cereal aphids was annualy kept Hippodamia variegata (Coccinellidae).

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