scholarly journals Research Article Morphological, immunohistochemical and miRNA21 expression manifestations related to cellular apoptosis in focal cerebral ischemia in a rat alcoholism model

2020 ◽  
Vol 19 (4) ◽  
Author(s):  
D.P.C. Tirapelli ◽  
M.L.A. Cirino ◽  
J.P. da Silva ◽  
I.S. Gula ◽  
M.F.G.S. Tazima ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Research Article ◽  
Cellular Apoptosis

scholarly journals Research Article Lack of effect of exercise on the expression profiles of mir-16, mir-21, mir-155, caspase3 and bcl2 in a rat model of focal cerebral ischemia

2020 ◽  
Vol 19 (4) ◽  
Author(s):  
L.B. Porsani ◽  
M.L.A. Cirino ◽  
F.S. Lizarte Neto ◽  
R.Z. Figueiredo ◽  
C.A.M. de Carvalho ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Rat Model ◽  
Focal Cerebral Ischemia ◽  
Expression Profiles ◽  
Research Article

scholarly journals Analysis of Caspase-9 protein and microRNAs miR-21, miR-126 and miR-155 related to the apoptosis mechanism in the cerebellum of rats submitted to focal cerebral ischemia associated with an alcoholism model

2019 ◽  
Vol 77 (10) ◽  
pp. 689-695 ◽  
Author(s):  
Jairo Pinheiro da SILVA ◽  
Fermino Sanches LIZARTE NETO ◽  
Mucio Luiz de Assis CIRINO ◽  
Camila Albuquerque Melo de CARVALHO ◽  
Carlos Gilberto CARLOTTI JR ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Immunohistochemical Analysis ◽  
Artery Occlusion ◽  
Control Group ◽  
Caspase 9 ◽  
Group I ◽  
Group A ◽  
Cellular Apoptosis ◽  
Cerebral Artery Occlusion

ABSTRACT This study aimed to analyze the cerebellum of rats submitted to an experimental focal cerebral ischemia, by middle cerebral artery occlusion for 90 minutes, followed by reperfusion for 48 hours, associated with an alcoholism model. Methods Fifty adult Wistar rats were used, subdivided into five experimental groups: control group (C): animals submitted to anesthesia only; sham group (S): animals submitted to complete simulation of the surgical procedure; ischemic group (I): animals submitted to focal cerebral ischemia for 90 minutes followed by reperfusion for 48 hours; alcoholic group (A): animals that received daily absolute ethanol diluted 20% in water for four weeks; and, ischemic and alcoholic group (I + A): animals receiving the same treatment as group A and, after four weeks, submitted to focal cerebral ischemia for 90 minutes, followed by reperfusion for 48 hours. The cerebellum samples were collected and immunohistochemical analysis of Caspase-9 protein and serum analysis by RT-PCR of microRNAs miR-21, miR-126 and miR155 were performed. Results The expression of Caspase-9 was higher in groups I, A and I + A. In the microRNAs analyses, miR-126 was higher in groups A and I + A, miR-155 was higher in groups I and I + A. Conclusions We conclude that apoptosis occurs in the cerebellar cortex, even if it is distant from the ischemic focus, and that microRNAs 126 and 155 show a correlation with cellular apoptosis in ischemic rats and those submitted to the chronic alcohol model.

scholarly journals Research Article Expression of miR-15b, miR-29b, miR-219 and miR-222 microRNAs in rats with focal cerebral ischemia submitted to physical exercise

2019 ◽  
Vol 18 (4) ◽  
Author(s):  
M.L.A. Cirino ◽  
L.B. Porsani ◽  
F.S. Lizarte Neto ◽  
M.F.G.S. Tazima ◽  
R.F. Zimak ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Physical Exercise ◽  
Focal Cerebral Ischemia ◽  
Research Article

PPAR-γ agonist rosiglitazone decreases focal cerebral ischemia-induced inflammation and brain damage in adult mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S94-S94
Author(s):  
Kudret Tureyen ◽  
Ramya Sundaresan ◽  
Kellie Bowen ◽  
Raghu Vemuganti
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Adult Mice ◽  
Ppar Γ

Negative neurovascular coupling during anoxic depolarization and peri-infarct spreading depressions in acute focal cerebral ischemia in mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S425-S425
Author(s):  
Cenk Ayata ◽  
Hwa Kyoung Shin ◽  
Phillip Jones ◽  
Andrew K Dunn ◽  
David A Boas ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neurovascular Coupling ◽  
Anoxic Depolarization
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