scholarly journals Research Article GSTT1 null genotype in sickle cell anemia and blood transfusion recurrence – a case report

2019 ◽  
Vol 18 (2) ◽  
Author(s):  
O.S. Dias Neto ◽  
K.S.F. e Silva ◽  
A.M. Barbosa ◽  
D.A. Rodrigues ◽  
M.H. Lagares ◽  
...  
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Research Article

SICKLE CELL ANEMIA: CASE REPORT

1925 ◽  
Vol 18 (11) ◽  
pp. 795-796 ◽  
Author(s):  
S Chaille Jamison
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anemia

scholarly journals Myth: Blood transfusion is effective for sickle cell anemia—associated priapism

CJEM ◽  
2006 ◽  
Vol 8 (02) ◽  
pp. 119-122 ◽  
Author(s):  
Andrew L. Merritt ◽  
Christopher Haiman ◽  
Sean O. Henderson
Keyword(s):  
Blood Transfusion ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Conventional Therapy ◽  
Case Reports ◽  
Complete Information ◽  
Effective Therapy ◽  
Transfusion Therapy ◽  
Medline Search ◽  
Neurologic Sequelae

ABSTRACTObjective:Priapism is a recognized complication of sickle cell anemia (SCA). When initial conventional treatments fail, simple or exchange blood transfusion has been advocated as a secondary intervention. However, recent literature suggests this may not be an effective therapy and may have significant neurologic sequelae. This paper reviews and summarizes the effectiveness and risks of blood transfusion compared with conventional priapism therapy.Methods:All relevant papers identified from a MEDLINE search were systematically examined for data related to the use of blood transfusion in the setting of priapism due to SCA. The effectiveness of conventional therapy was compared with transfusion therapy using the outcome of “time to detumescence” (TTD). In addition, papers documenting adverse neurologic sequela were reviewed and summarized.Results:Forty-two case reports were identified containing complete information with regard to patient age and TTD. The mean TTD was 8.0 days with conventional therapy (n= 16) and 10.8 days with blood transfusion therapy (n= 26). Adverse neurologic sequelae from blood transfusion therapy was described in 9 cases, with long term outcomes ranging from complete resolution to severe residual deficits.Conclusion:The current literature does not support the contention that blood transfusion is an effective therapy in the treatment of priapism due to SCA, as defined by an acceleration of TTD. In fact, numerous reports suggest that serious neurologic sequelae may result from this treatment. We feel the routine use of this therapy cannot be recommended.

scholarly journals Case Report: Splenectomy in Sickle Cell Anemia: Report of a Case and Review of the Literature

Blood ◽  
1951 ◽  
Vol 6 (4) ◽  
pp. 365-371 ◽  
Author(s):  
DONALD SHOTTON ◽  
CHARLES L. CROCKETT ◽  
BYRD S. LEAVELL
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
General Condition ◽  
Marked Improvement ◽  
Therapeutic Procedure ◽  
Review Of The Literature

Abstract 1. A case of sickle cell anemia who had numerous hemolytic crises and also hypersplenic effects such as pancytopenia was treated by splenectomy with marked improvement in general condition and in the blood. The literature relating to this subject is reviewed. Those cases with the largest spleens appear to have shown the most striking degrees of improvement. 2. In cases of sickle cell anemia showing various indications of hypersplenism, and excessive hemolysis, splenectomy may be a rational therapeutic procedure.

scholarly journals Subperiosteal hematoma and orbital compression syndrome following minor frontal trauma in sickle cell anemia: case report

2008 ◽  
Vol 71 (2) ◽  
pp. 262-264 ◽  
Author(s):  
Fernando Procianoy ◽  
Mauro Brandão Filho ◽  
Antonio Augusto Velasco e Cruz ◽  
Victor Marques Alencar
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Compression Syndrome

scholarly journals ALLOIMMUNIZATION IN PATIENTS WITH SICKLE CELL DISEASE AND THALASSAEMIA: EXPERIENCE OF SINGLE CENTRE FROM OMAN

2017 ◽  
Vol 9 (1) ◽  
pp. e2017013 ◽  
Author(s):  
Anil Pathare ◽  
Salam Alkindi
Keyword(s):  
Sickle Cell Disease ◽  
Blood Transfusion ◽  
Supportive Care ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Significant Risk ◽  
Red Cell ◽  
Cell Disease ◽  
Single Centre ◽  
Screening And Identification

Background: Blood transfusion is an integral part of the supportive care for patients with sickle cell anemia and thalassaemia. The hazard of red cell alloimmunization, however, is one of the main complications of this therapy. Objectives: The aim of this study was to evaluate the incidence of red cell alloimmunization in Omani patients with sickle cell anemia and thalassaemia. Methods: This study included 262 patients whose historical transfusion records were available. One hundred and twenty-nine patients with thalassaemia who were attending the day care unit for regular transfusions, and 133 sickle cell anemia patients admitted at our hospital were included in this study. The Diamed gel system was used for the screening and identification of atypical antibodies. Results: The rate of alloimmunization in sickle cell anemia patients was 31% (n=41), whereas in thalassaemia patients it was 20% (n=26). Antibodies to E, e, C, c, D, K, S, Fyª, Kpª, Jkª and Cw were observed. Among the two groups, 8 developed nonspecific antibodies, and 12 developed more than one antibody; however, 85% of patients were also immunized to Rh and Kell antigens. Conclusions: Red cell transfusions are associated with a significant risk of alloimmunization. It is, therefore, imperative to perform an initial extended red cell phenotyping for both donors and recipients, and carefully select ABO, Rh and Kell matched donors.

C0394 Stroke in sickle cell anemia: A case report

2012 ◽  
Vol 130 ◽  
pp. S161
Author(s):  
Yurdanur Kilinç ◽  
Barbaros Şahin Karagün ◽  
Esra Pekoak ◽  
İlgen Şaşmaz
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anemia
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