scholarly journals Correlation analysis between the delayed rectifier potassium channel KCNE1 (G38S) polymorphism and atrial fibrillation among the senior Uygur population in Xinjiang

2015 ◽  
Vol 14 (4) ◽  
pp. 15906-15912 ◽  
Author(s):  
N. Wugeti ◽  
G. Yu-Jun ◽  
S. Juan ◽  
A. Mahemuti
Keyword(s):  
Atrial Fibrillation ◽  
Correlation Analysis ◽  
Potassium Channel ◽  
Delayed Rectifier ◽  
Delayed Rectifier Potassium Channel ◽  
Rectifier Potassium Channel ◽  
Uygur Population

scholarly journals MinkS38G Gene Polymorphism and Atrial Fibrillation in the Chinese Population: A Meta-Analysis of 1871 Participants

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Yan-yan Li ◽  
Lian-sheng Wang ◽  
Xin-zheng Lu
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphism ◽  
Potassium Channel ◽  
Chinese Population ◽  
Meta Analysis ◽  
Delayed Rectifier ◽  
Channel Current ◽  
Delayed Rectifier Potassium Channel ◽  
The Individual ◽  
Rectifier Potassium Channel

Minkgene S38G polymorphism in theβ-subunit of slow activating component of the delayed rectifier potassium channel current potassium channel has been associated with increased atrial fibrillation (AF) risk. However, the individual studies results were still controversial. To investigate the association ofMinkS38G gene polymorphisms with AF, a meta-analysis including 1871 subjects from six individual studies was conducted.MinkS38G gene polymorphism was significantly related to AF under allelic (OR: 1.380, 95% CI: 1.200–1.600,P<0.00001), recessive (OR: 1.193, 95% CI: 1.033–1.377,P=0.017), dominant (OR: 1.057, 95% CI: 1.025–1.089,P<0.00001), additive (OR: 1.105, 95% CI: 1.036–1.178,P=0.002), homozygous (OR: 1.128, 95% CI: 1.068–1.191,P<0.00001), and heterozygous genetic models (OR: 1.078, 95% CI: 1.014–1.146,P=0.016). A significant association betweenMinkS38G gene polymorphism and AF risk was found. G allele carriers may predispose to AF.

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