In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells

2014 ◽  
Vol 13 (2) ◽  
pp. 3981-3990 ◽  
Author(s):  
M.A. Ali ◽  
M. Abul Farah ◽  
F.M. Al-Hemaid ◽  
F.M. Abou-Tarboush
Keyword(s):  
Saudi Arabia ◽  
Plant Extracts ◽  
In Vitro Cytotoxicity ◽  
Wild Plant ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Human Breast Adenocarcinoma ◽  
Adenocarcinoma Cells

Gadopentatic acid affects in vitro proliferation and doxorubicin response in human breast adenocarcinoma cells

BioMetals ◽  
2018 ◽  
Vol 31 (4) ◽  
pp. 605-616 ◽  
Author(s):  
Abdel Rahman Abdel Fattah ◽  
Sarah Mishriki ◽  
Tobias Kammann ◽  
Rakesh P. Sahu ◽  
Fei Geng ◽  
...  
Keyword(s):  
Breast Adenocarcinoma ◽  
Human Breast ◽  
In Vitro Proliferation ◽  
Human Breast Adenocarcinoma ◽  
Adenocarcinoma Cells

Synthesis and Biological Evaluation of Some A,D-Ring Modified 16,17-Secoandrostane Derivatives

2008 ◽  
Vol 73 (5) ◽  
pp. 627-636 ◽  
Author(s):  
Evgenija A. Djurendić ◽  
Marina P. Zaviš ◽  
Marija N. Sakač ◽  
Vesna V. Kojić ◽  
Gordana M. Bogdanović ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
In Vitro Cytotoxicity ◽  
Breast Adenocarcinoma ◽  
Hydroxy Derivative ◽  
Aromatase Activity ◽  
Human Breast ◽  
Human Breast Adenocarcinoma ◽  
Alkaline Conditions ◽  
Pc3 Cells

Starting from 3β-hydroxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1), the new 16,17-secoandrostane derivatives 2-11 were synthesized. Protection of the 17-oxo function of compound 1 with ethylene glycol yielded compounds 2 and 3. The Oppenauer oxidation of 2 or oxidation with H2O2 in alkaline conditions gave the respective compounds 4 and 10. Epoxidation of compound 4 yielded a mixture of 4α,5α- and 4β,5β-epoxides 5 and 6 and a mixture of 4α,5α- and 4β,5β-epoxy-carboxamides 7 and 8. Opening of the oxirane ring of a mixture of compounds 5 and 6 with formic acid afforded the 4-hydroxy derivative 9. Anti-aromatase activity and in vitro cytotoxicity for three tumor cell lines (human breast adenocarcinoma ER+, MCF-7 as well as human breast adenocarcinoma ER-, MDA-MB-231, and prostate cancer, PC3) of selected compounds were evaluated. Compounds 2, 4, 9, and 10 showed a strong cytotoxicity for PC3 cells.

scholarly journals Preliminary phytochemical screening and anticancer potential of Kohautia aspera (Heyne Ex Roth) Bremek

2019 ◽  
Vol 10 (3) ◽  
pp. 2502-2506
Author(s):  
Kavitha G ◽  
Sivakkumar T ◽  
Elessy Abraham
Keyword(s):  
Breast Adenocarcinoma ◽  
Phytochemical Screening ◽  
Human Breast ◽  
Human Breast Adenocarcinoma ◽  
Percolation Method ◽  
Adenocarcinoma Cells ◽  
Successive Extraction ◽  
Potential Evaluation ◽  
Mcf 7

Phytochemical screening followed by anticancer potential evaluation of Kohautia aspera (Heyne ex Roth) Bremek was the purpose of the study. Successive extraction was performed with four solvents of different polarity as well as hot percolation method for the aqueous extract. The anticancer potential of the plant was investigated by standard MTT assay against (MCF-7) human breast adenocarcinoma cells. The extracts showed many phytoconstituents. In vitro cytotoxic activity of plant increased with increasing concentration of extracts. The presence of important phytoconstituents in plants may provide protection against a number of diseases. The investigation concludes that Kohautia aspera (Heyne ex Roth) Bremek possesses significant anticancer potential.

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