scholarly journals Positions of pluripotency genes and hepatocyte-specific genes in the nucleus before and after mouse ES cell differentiation

2014 ◽  
Vol 13 (1) ◽  
pp. 1979-1988 ◽  
Author(s):  
K. Udagawa ◽  
T. Ohyama
Keyword(s):  
Cell Differentiation ◽  
Es Cell ◽  
Before And After ◽  
Pluripotency Genes ◽  
Mouse Es Cell

Rat bone marrow derived mesenchymal progenitor cells support mouse ES cell growth and germ-like cell differentiation

2009 ◽  
Vol 33 (3) ◽  
pp. 434-441 ◽  
Author(s):  
Guanghui Cui ◽  
Zhengyu Qi ◽  
Xin Guo ◽  
Jie Qin ◽  
Yaoting Gui ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Differentiation ◽  
Cell Growth ◽  
Progenitor Cells ◽  
Es Cell ◽  
Mesenchymal Progenitor Cells ◽  
Rat Bone ◽  
Mouse Es Cell

scholarly journals A conserved role of Shp2 in regulation of human and mouse ES cell differentiation

Cell Research ◽  
2008 ◽  
Vol 18 (S1) ◽  
pp. S27-S27
Author(s):  
Dongmei Wu ◽  
Yuhong Pang ◽  
Yuehai Ke ◽  
Zhao He ◽  
Gen-Sheng Feng
Keyword(s):  
Cell Differentiation ◽  
Es Cell ◽  
Human And Mouse ◽  
Mouse Es Cell

Enforced Expression ofMixl1During Mouse ES Cell Differentiation Suppresses Hematopoietic Mesoderm and Promotes Endoderm Formation

Stem Cells ◽  
2009 ◽  
Vol 27 (2) ◽  
pp. 363-374 ◽  
Author(s):  
Sue Mei Lim ◽  
Lloyd Pereira ◽  
Michael S. Wong ◽  
Claire E. Hirst ◽  
Benjamin E. Van Vranken ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Es Cell ◽  
Mouse Es Cell

scholarly journals An Inducible Expression System of the Calcium-Activated Potassium Channel 4 to Study the Differential Impact on Embryonic Stem Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Stefan Liebau ◽  
Michael Tischendorf ◽  
Daniel Ansorge ◽  
Leonhard Linta ◽  
Marianne Stockmann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Cell Line ◽  
Es Cells ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Pacemaker Cell ◽  
Es Cell ◽  
Sk Channel ◽  
Mouse Es Cell

Rationale. The family of calcium-activated potassium channels consists of four members with varying biological functions and conductances. Besides membrane potential modulation, SK channels have been found to be involved in cardiac pacemaker cell development from ES cells and morphological shaping of neural stem cells.Objective. Distinct SK channel subtype expression in ES cells might elucidate their precise impact during cardiac development. We chose SK channel subtype 4 as a potential candidate influencing embryonic stem cell differentiation.Methods. We generated a doxycycline inducible mouse ES cell line via targeted homologous recombination of a cassette expressing a bicistronic construct encoding SK4 and a fluorophore from the murine HPRT locus.Conclusion. We characterized the mouse ES cell line iSK4-AcGFP. The cassette is readily expressed under the control of doxycycline, and the overexpression of SK4 led to an increase in cardiac and pacemaker cell differentiation thereby serving as a unique tool to characterize the cell biological variances due to specific SK channel overexpression.

scholarly journals Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts

2008 ◽  
Vol 314 (14) ◽  
pp. 2634-2642 ◽  
Author(s):  
Thierry Bru ◽  
Catriona Clarke ◽  
Michael J. McGrew ◽  
Helen M. Sang ◽  
Ian Wilmut ◽  
...  
Keyword(s):  
Somatic Cells ◽  
Es Cell ◽  
Rapid Induction ◽  
Cell Extracts ◽  
Pluripotency Genes ◽  
Mouse Es Cell

scholarly journals Orphan Nuclear Receptor GCNF Is Required for the Repression of Pluripotency Genes during Retinoic Acid-Induced Embryonic Stem Cell Differentiation

2005 ◽  
Vol 25 (19) ◽  
pp. 8507-8519 ◽  
Author(s):  
Peili Gu ◽  
Damien LeMenuet ◽  
Arthur C.-K. Chung ◽  
Michael Mancini ◽  
David A. Wheeler ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Retinoic Acid ◽  
Cell Differentiation ◽  
Embryonic Development ◽  
Nuclear Receptor ◽  
Es Cells ◽  
Embryonic Stem ◽  
Orphan Nuclear Receptor ◽  
Es Cell ◽  
Pluripotency Genes

ABSTRACT Embryonic stem (ES) cell pluripotency and differentiation are controlled by a network of transcription factors and signaling molecules. Transcription factors such as Oct4 and Nanog are required for self-renewal and maintain the undifferentiated state of ES cells. Decreases in the expression of these factors indicate the initiation of differentiation of ES cells. Inactivation of the gene encoding the orphan nuclear receptor GCNF showed that it plays an important role in the repression of Oct4 expression in somatic cells during early embryonic development. GCNF −/− ES cells were isolated to study the function of GCNF in the down-regulation of pluripotency genes during differentiation. Loss of repression of ES cell marker genes Oct4, Nanog, Sox2, FGF4, and Stella was observed upon treatment of GCNF −/− ES cells with retinoic acid. The loss of repression of pluripotency genes is either a direct or indirect consequence of loss of GCNF. Both the Oct4 and Nanog genes are direct targets of GCNF repression during ES cell differentiation and early mouse embryonic development. In contrast Sox2 and FGF4 are indirectly regulated by GCNF through Oct4. These findings establish a central role for GCNF in the repression of pluripotency gene expression during retinoic acid-induced ES cell differentiation.

scholarly journals Regulation of Pax6 by CTCF during Induction of Mouse ES Cell Differentiation

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20954 ◽  
Author(s):  
Jie Gao ◽  
Jie Wang ◽  
Yumei Wang ◽  
Wei Dai ◽  
Luo Lu
Keyword(s):  
Cell Differentiation ◽  
Es Cell ◽  
Mouse Es Cell

Induction of melanocyte precursors from neural crest cells surrounding the neural tube-like structures developed in vitro using mouse ES cell culture

2007 ◽  
Vol 27 (1) ◽  
pp. 45-52
Author(s):  
Koh-ichi Atoh ◽  
Manae S. Kurokawa ◽  
Hideshi Yoshikawa ◽  
Chieko Masuda ◽  
Erika Takada ◽  
...  
Keyword(s):  
Cell Culture ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Es Cell ◽  
Mouse Es Cell
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