scholarly journals The role of Hsp90α in heat-induced apoptosis and cell damage in primary myocardial cell cultures of neonatal rats

2013 ◽  
Vol 12 (4) ◽  
pp. 6080-6091 ◽  
Author(s):  
A. Islam ◽  
Y.J. Lv ◽  
A. Abdelnasir ◽  
B. Rehana ◽  
Z.J. Liu ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Cell Damage ◽  
Myocardial Cell ◽  
Neonatal Rats ◽  
Induced Apoptosis ◽  
Myocardial Cell Cultures

scholarly journals Lactobacilli Reduce Cell Cytotoxicity Caused byStreptococcus pyogenesby Producing Lactic Acid That Degrades the Toxic Component Lipoteichoic Acid

2011 ◽  
Vol 55 (4) ◽  
pp. 1622-1628 ◽  
Author(s):  
Lisa Maudsdotter ◽  
Hans Jonsson ◽  
Stefan Roos ◽  
Ann-Beth Jonsson
Keyword(s):  
Lactic Acid ◽  
Host Cell ◽  
Cell Damage ◽  
Lipoteichoic Acid ◽  
Cell Cytotoxicity ◽  
Invasive Infections ◽  
Group A ◽  
Complement Regulator ◽  
Induced Apoptosis

ABSTRACTLactobacilli are known to prevent colonization by many pathogens; nevertheless, the mechanisms of their protective effect are largely unknown. In this work, we investigated the role of lactobacilli during infection of epithelial cells with group A streptococci (GAS). GAS cause a variety of illnesses ranging from noninvasive disease to more severe invasive infections, such as necrotizing fasciitis and toxic shock-like syndrome. Invasion of deeper tissues is facilitated by GAS-induced apoptosis and cell death. We found that lactobacilli inhibit GAS-induced host cell cytotoxicity and shedding of the complement regulator CD46. Further, survival assays demonstrated that lactic acid secreted by lactobacilli is highly bactericidal toward GAS. In addition, lactic acid treatment of GAS, but not heat killing, prior to infection abolishes the cytotoxic effects against human cells. Since lipoteichoic acid (LTA) of GAS is heat resistant and cytotoxic, we explored the effects of lactic acid on LTA. By applying such an approach, we demonstrate that lactic acid reduces epithelial cell damage caused by GAS by degrading both secreted and cell-bound LTA. Taken together, our experiments reveal a mechanism by which lactobacilli prevent pathogen-induced host cell damage.

Evaluation of the combined toxic effects of cocaine and ethanol on primary myocardial cell cultures

1991 ◽  
Vol 5 (3) ◽  
pp. 247-255 ◽  
Author(s):  
A.A. Welder ◽  
J.F. O'Dell ◽  
R.B. Melchert ◽  
J.A. Eselin
Keyword(s):  
Cell Cultures ◽  
Myocardial Cell ◽  
Toxic Effects ◽  
Myocardial Cell Cultures

Choline uptake in myocardial cell cultures

Life Sciences ◽  
1972 ◽  
Vol 11 (6) ◽  
pp. 269-275 ◽  
Author(s):  
David E. Clarke ◽  
Robert J. Ertel ◽  
Greta Ouyang ◽  
Frederick R. Franke
Keyword(s):  
Cell Cultures ◽  
Myocardial Cell ◽  
Choline Uptake ◽  
Myocardial Cell Cultures

Effects of Nitrendipine on Cocaine-Induced Toxicity Evaluated in Primary Myocardial Cell Cultures

1991 ◽  
Vol 80 (7) ◽  
pp. 700-704 ◽  
Author(s):  
Russell B. Melchert ◽  
Julie A. Eselin ◽  
Jennifer F. O’Dell ◽  
Allison A. Welder
Keyword(s):  
Cell Cultures ◽  
Myocardial Cell ◽  
Myocardial Cell Cultures
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