scholarly journals Ubiquitin Reduces Expression of Intercellular Adhesion Molecules and Tumor Necrosis Factor-α in Lung Tissue of Experimental Acute Lung Injury

2012 ◽  
Vol 02 (03) ◽  
pp. 151-154 ◽  
Author(s):  
Zhenyang He ◽  
Xing Juan
Keyword(s):  
Acute Lung Injury ◽  
Tumor Necrosis Factor ◽  
Lung Injury ◽  
Adhesion Molecules ◽  
Lung Tissue ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intercellular Adhesion Molecules ◽  
Factor Α ◽  
Necrosis Factor

Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12

2001 ◽  
Vol 280 (6) ◽  
pp. L1128-L1137 ◽  
Author(s):  
Takashige Maeyama ◽  
Kazuyoshi Kuwano ◽  
Masayuki Kawasaki ◽  
Ritsuko Kunitake ◽  
Naoki Hagimoto ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Lung Injury ◽  
Lung Tissue ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
T Helper ◽  
Antibody Treatment ◽  
Factor Α ◽  
Necrosis Factor ◽  
Helper Type

We previously demonstrated essential roles of the Fas-Fas ligand (FasL) pathway in bleomycin-induced pneumopathy in mice. T lymphocytes and natural killer cells express FasL on activation and use it as a cytotoxic effector molecule. Because interleukin (IL)-12 is known to play a critical role in cell-mediated immunity, we investigated whether anti-IL-12 antibody treatment suppresses the development of this model. The anti-IL-12 antibody treatment decreased the number of apoptotic cells and the degree of inflammation and fibrosis in lung tissue. The results of RT-PCR showed that IL-12p40, IL-12 receptor (R) β2, interferon-γ, tumor necrosis factor-α and FasL mRNAs were upregulated after bleomycin instillation. The upregulation of FasL, IL-12Rβ2, and tumor necrosis factor-α mRNA expression in lung tissue was suppressed by anti-IL-12 antibody treatment. The results of enzyme-linked immunosorbent assay showed that the levels of IL-12p40, but not of IL-12p70, were increased in lung tissue after bleomycin instillation. Although the increase in IL-12Rβ2 mRNA levels suggests that the T helper type 1 cell response may participate in lung injury, the increase in IL-12p40 supports T helper type 2 cell predominance in the fibrotic process of this model. The administration of anti-IL-12 antibody could be a novel therapy against lung injury and pulmonary fibrosis.

ACID-INDUCED ACUTE LUNG INJURY IN MICE IS ASSOCIATED WITH P44/42 AND C-JUN N-TERMINAL KINASE ACTIVATION AND REQUIRES THE FUNCTION OF TUMOR NECROSIS FACTOR α RECEPTOR I

Shock ◽  
2012 ◽  
Vol 38 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Nikolaos A. Maniatis ◽  
Aggeliki Sfika ◽  
Ioanna Nikitopoulou ◽  
Alice G. Vassiliou ◽  
Christina Magkou ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Tumor Necrosis Factor ◽  
Lung Injury ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Kinase Activation ◽  
Factor Α ◽  
Necrosis Factor

COMBINED IBUPROFEN AND MONOCLONAL ANTIBODY TO TUMOR NECROSIS FACTOR-α ATTENUATE HEMODYNAMIC DYSFUNCTION AND SEPSIS-INDUCED ACUTE LUNG INJURY

1993 ◽  
Vol 34 (5) ◽  
pp. 612-621 ◽  
Author(s):  
Patrick G. Mullen ◽  
Alastair C. J. Windsor ◽  
Ciaran J. Walsh ◽  
Charles R. Blocher ◽  
Bernard J. Fisher ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Acute Lung Injury ◽  
Tumor Necrosis Factor ◽  
Lung Injury ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor
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