scholarly journals Influence of Treatments for Depression and Sleep Quality on Heart Rate and Blood Pressure in Individuals with Hypertension and Depression

2015 ◽  
Vol 05 (02) ◽  
pp. 137-154
Author(s):  
Marcello Finardi Peixoto ◽  
Mario Luis Ribeiro Cesaretti ◽  
Agostinho Tavares
2012 ◽  
Vol 7 ◽  
pp. IMI.S9720 ◽  
Author(s):  
Cameron G. McCarthy ◽  
Rick J. Alleman ◽  
Zach W. Bell ◽  
Richard J. Bloomer

Background Impaired sleep quality is commonplace within industrialized societies, as evidenced by the increasing number of prescription sleep aids available. Certain herbal preparations have been suggested to provide a natural benefit to sleep; however, limited controlled data are available documenting this benefit. In the present study we tested the effect of an experimental dietary supplement, containing the active ingredients Chlorophytum borivilianum and Velvet bean, on sleep quality using the Pittsburgh Sleep Quality Index (PSQI). Methods Eighteen healthy and active men and women, with evidence of impaired sleep quality, consumed the supplement daily for 28 days. The PSQI was administered before and after the intervention period. As indicators of safety, resting heart rate and blood pressure were measured, and a complete blood count, comprehensive metabolic panel, and lipid panel were determined. Results Sleep quality was influenced by the supplement, as evidenced by an improvement in every category of the PSQI questionnaire ( P < 0.05), with most category scores improving approximately 50% from pre to post intervention. No adverse outcomes were noted with use of the supplement, as indicated by no change in resting heart rate, blood pressure, or any bloodborne parameter. Conclusions An investigational dietary supplement containing the active ingredients Chlorophytum borivilianum and Velvet bean improves sleep quality in men and women. Additional placebo controlled trials are needed to corroborate these findings in individuals with self-reported sleeping difficulty.


Author(s):  
Farrukh Majeed ◽  
Rabia Latif ◽  
Aamna Latif ◽  
Rehma BiBi

Objectives: Disturbed sleep patterns might alter the autonomic tone and may lead to various cardiovascular morbidities. This study aimed to determine sleep patterns (quality, duration, efficiency and day time sleepiness) and explore their association with blood pressure (BP) and heart rate variability (HRV) in young apparently healthy young Saudi females. Methods: This cross-sectional study was conducted in the Physiology department, ------University, Saudi Arabia. Self-reported Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaires were used to collect data from 98 female participants. Participant’s blood pressure was recorded with Finometer® and HRV was measured from ECG using PowerLab®. Based on the cut-off values of sleep quality, duration, efficiency and daytime sleepiness scores, students were categorized into groups. HRV and BP were compared between the groups by t test/One-way ANOVA. Results: Poor sleep patterns (quality, duration, efficiency) were observed but no association was found in BP and HRV parameters among groups of different sleep quality, duration, and efficiency. Systolic blood pressure was significantly increased in moderate to severe day time sleepiness group (P=0.039). Dozing off as a passenger in a car doze, in afternoon and after lunch were negatively correlated with HRV parameters (P < 0.05). Conclusion: Sleep quality, duration and efficiency were not found to be statistically significant, but various doze off situations were associated with HRV parameters. Day time sleepiness may augment sympathetic response in apparently healthy female participants. Keywords: sleep patterns, day time sleepiness, blood pressure, heart rate variability, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale.


2007 ◽  
Vol 21 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Yunfeng Sun ◽  
Yinling Zhang ◽  
Ning He ◽  
Xufeng Liu ◽  
Danmin Miao

Abstract. Caffeine placebo expectation seems to improve vigilance and cognitive performance. This study investigated the effect of caffeine and placebo expectation on vigilance and cognitive performance during 28 h sleep deprivation. Ten healthy males volunteered to take part in the double-blind, cross-over study, which required participants to complete five treatment periods of 28 h separated by 1-week wash-out intervals. The treatments were no substance (Control); caffeine 200 mg at 00:00 (C200); placebo 200 mg at 00:00 (P200); twice caffeine 200 mg at 00:00 and 04:00 (C200-C200); caffeine 200 mg at 00:00 and placebo 200 mg at 04:00 (C200-P200). Participants were told that all capsules were caffeine and given information about the effects of caffeine to increase expectation. Vigilance was assessed by a three-letter cancellation test, cognitive functions by the continuous addition test and Stroop test, and cardiovascular regulation by heart rate and blood pressure. Tests were performed bihourly from 00:00 to 10:00 of the second day. Results indicated that C200-P200 and C200-C200 were more alert (p < .05) than Control and P200. Their cognitive functions were higher (p < .05) than Control and P200. Also, C200-P200 scored higher than C200 in the letter cancellation task (p < .05). No test showed any significant differences between C200-P200 and C200-C200. The results demonstrated that the combination of caffeine 200 mg and placebo 200 mg expectation exerted prolonged positive effects on vigilance and cognitive performance.


2009 ◽  
Vol 23 (3) ◽  
pp. 104-112 ◽  
Author(s):  
Stefan Duschek ◽  
Heike Heiss ◽  
Boriana Buechner ◽  
Rainer Schandry

Recent studies have revealed evidence for increased pain sensitivity in individuals with chronically low blood pressure. The present trial explored whether pain sensitivity can be reduced by pharmacological elevation of blood pressure. Effects of the sympathomimetic midodrine on threshold and tolerance to heat pain were examined in 52 hypotensive persons (mean blood pressure 96/61 mmHg) based on a randomized, placebo-controlled, double-blind design. Heat stimuli were applied to the forearm via a contact thermode. Confounding of drug effects on pain perception with changes in skin temperature, temperature sensitivity, and mood were statistically controlled for. Compared to placebo, higher pain threshold and tolerance, increased blood pressure, as well as reduced heart rate were observed under the sympathomimetic condition. Increases in systolic blood pressure between points of measurement correlated positively with increases in pain threshold and tolerance, and decreases in heart rate were associated with increases in pain threshold. The findings underline the causal role of hypotension in the augmented pain sensitivity related to this condition. Pain reduction as a function of heart rate decrease suggests involvement of a baroreceptor-related mechanism in the pain attrition. The increased proneness of persons with chronic hypotension toward clinical pain is discussed.


2009 ◽  
Vol 23 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Matthew C. Whited ◽  
Kevin T. Larkin

Sex differences in cardiovascular reactivity to stress are well documented, with some studies showing women having greater heart rate responses than men, and men having greater blood pressure responses than women, while other studies show conflicting evidence. Few studies have attended to the gender relevance of tasks employed in these studies. This study investigated cardiovascular reactivity to two interpersonal stressors consistent with different gender roles to determine whether response differences exist between men and women. A total of 26 men and 31 women were assigned to either a traditional male-oriented task that involved interpersonal conflict (Conflict Task) or a traditional female-oriented task that involved comforting another person (Comfort Task). Results demonstrated that women exhibited greater heart rate reactions than men independent of the task type, and that men did not display a higher reactivity than women on any measure. These findings indicate that sex of participant was more important than gender relevance of the task in eliciting sex differences in cardiovascular responding.


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