scholarly journals Human umbilical cord-derived mesenchymal stromal cells promote sensory recovery in a spinal cord injury rat model

2013 ◽  
Vol 03 (03) ◽  
pp. 155-163 ◽  
Author(s):  
Sachiko Takikawa ◽  
Akihito Yamamoto ◽  
Kiyoshi Sakai ◽  
Ryutaro Shohara ◽  
Akira Iwase ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Human Umbilical Cord ◽  
Cord Injury ◽  
Sensory Recovery

Functional recovery after transplantation of bone marrow-derived human mesenchymal stromal cells in a rat model of spinal cord injury

Cytotherapy ◽  
2010 ◽  
Vol 12 (6) ◽  
pp. 792-806 ◽  
Author(s):  
Rakhi Pal ◽  
Chaitanya Gopinath ◽  
Nagesh M Rao ◽  
Poulomi Banerjee ◽  
Venkatesh Krishnamoorthy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Mesenchymal Stromal Cells ◽  
Functional Recovery ◽  
Rat Model ◽  
Stromal Cells ◽  
Human Mesenchymal Stromal Cells ◽  
Cord Injury

scholarly journals Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jing Zhang ◽  
Lian-Bing Li ◽  
Zhu Qiu ◽  
Hong-Bo Ren ◽  
Jia-Yan Wu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Antioxidant Enzymes ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Neuronal Damage ◽  
Human Umbilical Cord ◽  
Radiation Myelopathy ◽  
Multiple Injections ◽  
Tail Vein

The main aim of the present study was to assess the antioxidative effects of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in a rat model of radiation myelopathy. UC-MSCs were isolated from Wharton’s jelly (WJ) of umbilical cords. An irradiated cervical spinal cord rat model (C2-T2 segment) was generated using a60Co irradiator to deliver 30 Gy of radiation. UC-MSCs were injected through the tail vein at 90 days, 97 days, 104 days, and 111 days after-irradiation. Histological damage was examined by cresyl violet/Nissl staining. The activities of two antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) in the spinal cord were measured by the biomedical assay. In addition, the levels of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in the spinal cord were determined by ELISA methods. Multiple injections of UC-MSCs through the tail vein ameliorated neuronal damage in the spinal cord, increased the activities of the antioxidant enzymes CAT and GPX, and increased the levels of VEGF and Ang-2 in the spinal cord. Our results suggest that multiple injections of UC-MSCs via the tail vein in the rat model of radiation myelopathy could significantly improve the antioxidative microenvironment in vivo.

Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury

Cytotherapy ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. 434-448 ◽  
Author(s):  
Zhilai Zhou ◽  
Yinhai Chen ◽  
Hui Zhang ◽  
Shaoxiong Min ◽  
Bo Yu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cord Injury

Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid

2019 ◽  
Vol 16 (1) ◽  
pp. 167-180 ◽  
Author(s):  
Fabián Nishida ◽  
María F. Zappa Villar ◽  
Carolina N. Zanuzzi ◽  
María S. Sisti ◽  
Agustina E. Camiña ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Kainic Acid ◽  
Umbilical Cord ◽  
Human Umbilical Cord ◽  
Cord Injury
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