scholarly journals Anaplastic Lymphoma Kinase (ALK) and p53 Are Potentially Useful Markers to Distinguish Inflammatory Myofibroblastic Tumor

2013 ◽  
Vol 03 (02) ◽  
pp. 71-74
Author(s):  
Shinji Kurosaka ◽  
Kazumasa Matsumoto ◽  
Akira Irie ◽  
Takahiro Hirayama ◽  
Morihiro Nishi ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Inflammatory Myofibroblastic Tumor ◽  
Anaplastic Lymphoma

How long should we continue crizotinib in ALK translocation-positive inflammatory myofibroblastic tumors? Long-term complete response with crizotinib and review of the literature

2019 ◽  
Vol 26 (4) ◽  
pp. 1011-1018 ◽  
Author(s):  
Ozkan Alan ◽  
Okan Kuzhan ◽  
Sinan Koca ◽  
Tugba Akin Telli ◽  
Tugba Basoglu ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Inflammatory Myofibroblastic Tumor ◽  
Kinase Inhibitor ◽  
Case Reports ◽  
Tumor Control ◽  
Anaplastic Lymphoma Kinase Inhibitor ◽  
Anaplastic Lymphoma ◽  
Short Period ◽  
Inflammatory Myofibroblastic Tumors

Introduction Inflammatory myofibroblastic tumor is a rare disease which is typically seen in children and young adults. Approximately half of the inflammatory myofibroblastic tumors contain translocations that result in over-expression of anaplastic lymphoma kinase gene. Herein, we present two anaplastic lymphoma kinase-positive cases with long-term remission with crizotinib. We do not know how long these therapies need to be continued. Case reports We present two cases of inflammatory myofibroblastic tumor treated with anaplastic lymphoma kinase inhibitor therapies: an 8-year-old Turkish boy and a 21-year-old Caucasian man. Management and outcome Two cases, both with good tumor control under crizotinib, but one who progressed on drug holiday, responded again to the same drug, and had a very short period of response after restarting crizotinib. Conclusion A molecular-targeted drug (anaplastic lymphoma kinase inhibitor) was found to be extremely effective as selective therapy for inflammatory myofibroblastic tumor with anaplastic lymphoma kinase translocation. Here, we want to emphasize the continuation of this treatment after achieving a good response until progression or a major side effect.

Anaplastic Lymphoma Kinase‐Positive Inflammatory Myofibroblastic Tumor Mimicking Meningioma: A Case Report

Neurographics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 75-79
Author(s):  
J.B. Stone ◽  
R. Stonebridge ◽  
R.D. Bhuta ◽  
J.L. Boxerman
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Inflammatory Myofibroblastic Tumor ◽  
Malignant Degeneration ◽  
En Bloc ◽  
Anaplastic Lymphoma ◽  
Intracranial Involvement ◽  
Activating Mutation ◽  
Positive Immunostaining ◽  
Children And Young Adults ◽  
Fibrous Tumor

A 15-year-old girl presented with intermittent nausea and vomiting, headache, and vision changes. MR imaging of the brain revealed an avidly enhancing infratemporal dural-based mass arising from the tentorium, with hyperintensity on T2WI and transdural extension into the posterior cranial fossa. The well-encapsulated fibrous tumor was resected en bloc after cauterization of its rich tentorial arterial supply. Histologic examination demonstrated pleomorphic myofibroblastic cells admixed with an inflammatory infiltrate. Spindle cells showed strong, diffusely positive immunostaining for anaplastic lymphoma kinase, and genomic sequencing uncovered a tropomyosin 3 gene and anaplastic lymphoma kinase fusion and an activating mutation in the Kirsten rat sarcoma oncogene. A diagnosis of inflammatory myofibroblastic tumor was made. Primary intracranial involvement of inflammatory myofibroblastic tumor is exceptionally rare, and few cases that feature an anaplastic lymphoma kinase translocation have been described. Inflammatory myofibroblastic tumor‐CNS is an important differential diagnosis for dural-based lesions in children and young adults due to its propensity for recurrence and malignant degeneration.

Fusion of dynactin 1 to anaplastic lymphoma kinase in inflammatory myofibroblastic tumor

2012 ◽  
Vol 43 (11) ◽  
pp. 2047-2052 ◽  
Author(s):  
Xiaoke Wang ◽  
Chandra Krishnan ◽  
Edward P. Nguyen ◽  
Kevin J. Meyer ◽  
Jennifer L. Oliveira ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Inflammatory Myofibroblastic Tumor ◽  
Anaplastic Lymphoma
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