scholarly journals Human leukocyte antigen associations and c-reactive protein levels in lebanese patients with aggressive periodontitis—HLA and CRP in aggressive periodontitis

2011 ◽  
Vol 01 (02) ◽  
pp. 25-28
Author(s):  
Marita Chakhtoura ◽  
Nada M. Souccar ◽  
Nayla S. Al-Akl ◽  
Alexander M. Abdelnoor
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Aggressive Periodontitis ◽  
C Reactive Protein ◽  
Leukocyte Antigen ◽  
Protein Levels ◽  
Reactive Protein

Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: a meta-analysis

2008 ◽  
Vol 35 (3) ◽  
pp. 183-192 ◽  
Author(s):  
Jamal M. Stein ◽  
Helmut K. G. Machulla ◽  
Ralf Smeets ◽  
Friedrich Lampert ◽  
Stefan Reichert
Keyword(s):  
Human Leukocyte Antigen ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Aggressive Periodontitis ◽  
Leukocyte Antigen

Analysis of Gene Expression of Human Leukocyte Antigen B27 in Patients with Ankylosing Spondylitis and Correlation with Related Indicators

2021 ◽  
Author(s):  
Chun Liu ◽  
Zhong-Yu Kang ◽  
Wei Liu ◽  
Yuan Zhao ◽  
Dai-Hong Li
Keyword(s):  
Ankylosing Spondylitis ◽  
Human Leukocyte Antigen ◽  
Disease Duration ◽  
Clinical Manifestations ◽  
Human Leukocyte ◽  
Female Ratio ◽  
Leukocyte Antigen ◽  
Reactive Protein ◽  
Healthy Donors ◽  
Highly Correlated

Abstract The aim of this study was to investigate the potential correlation between the human leukocyte antigen (HLA)-B*27 subtypes in patients with ankylosing spondylitis (AS) and the clinical features of AS. The prevalence of HLA-B*27 subtypes was investigated in 132 healthy donors recruited from our center and in 143 patients with AS. We investigated the differences in HLA-B27 subtype status for the patients and healthy donors by using a PCR-SSP (polymerase chain reaction with sequence-specific primer) method. The clinical outcomes of the patients, including lower back pain, uveitis, peripheral arthritis, stiffness, joints, erythrocyte sedimentation rate (ESR), Anti-streptolysin O (ASO) and C-reactive protein (CRP), were recorded. The male-to-female ratio was 2.5, and the mean age at diagnosis was 29.3 years. HLA-B*27 positivity was detected in 111 patients (77.6%) of patients with AS. The rate of HLA-B*27 positivity was significantly higher in the AS group than patients without AS. The subtypes observed in patients with AS were HLA-B*2704 (55.9%, 62/111), HLA-B*2705 (39.6%, 44/111), HLA-B*2702 (1.80%, 2/111), HLA-B*2707 (0.90%, 1/111), and HLA-B*2704/05(1.80%, 2/111). The main genotypes were HLA-B*2704 and HLA-B*2705. There were no significant differences in clinical manifestations. Multivariate analysis showed statistically significant differences in sex (P=0.01), disease duration (P=0.023), hematocrit (P=0.01), and CRP (P=0.01) between patients in the HLA-B*27(+) AS group and the HLA-B*27(-) AS group. In addition, HLA-B*15, HLA-B*40, HLA-B*13, and HLA-B*46 were the major alleles with associated HLA-B types in patients with HLA-B*27(+) AS. Therefore, we conclude that HLA-B*27 is highly correlated with AS and can be used as an early predictor of AS. In addition, sex, disease duration, ESR, and CRP were significantly different in the HLA-B*27(+) AS group and HLA-B*27(-) AS group. Finally, our study also found a correlation between HLA-B*15, HLA-B*40, HLA-B*13, and HLA-B*46 subtypes and the development of AS.

C-Reactive Protein Levels in Patients With Aggressive Periodontitis

2006 ◽  
Vol 77 (6) ◽  
pp. 933-939 ◽  
Author(s):  
Trang N. Salzberg ◽  
Benjamin T. Overstreet ◽  
Jeffrey D. Rogers ◽  
Joseph V. Califano ◽  
Al M. Best ◽  
...  
Keyword(s):  
Aggressive Periodontitis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

Abstract # OR-8: Serum 25-Hydroxyvitamin D Associates with Human Leukocyte Antigen (HLA) Polymorphisms

2016 ◽  
Vol 22 ◽  
pp. 6
Author(s):  
Leena Kinnunen ◽  
Valma Harjutsalo ◽  
Heljä-Marja Surcel ◽  
Christel Lamberg-Allardt ◽  
Jaakko Tuomilehto ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
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