scholarly journals The Effect of Non-Invasive Goal Directed Fluid Administration on Graft Function in Deceased Donor Renal Transplantation: A Pilot Study

2016 ◽  
Vol 06 (03) ◽  
pp. 13-21
Author(s):  
Joseph R. Whiteley ◽  
Jason M. Taylor ◽  
John J. Freely Jr. ◽  
Thomas I. Epperson ◽  
Laura Bell ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Pilot Study ◽  
Graft Function ◽  
Deceased Donor ◽  
Fluid Administration ◽  
Non Invasive

Rejection evaluation after renal transplantation using MR diffusion tensor imaging

2017 ◽  
Vol 59 (7) ◽  
pp. 876-883 ◽  
Author(s):  
Emin Deger ◽  
Azim Celik ◽  
Hamad Dheir ◽  
Volkan Turunc ◽  
Ahmet Yardimci ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Renal Transplantation ◽  
Acute Rejection ◽  
Renal Cortex ◽  
Diffusion Tensor ◽  
Graft Function ◽  
The Other ◽  
Non Invasive ◽  
Transplant Patients ◽  
Allograft Function

Background Renal allograft dysfunction monitoring is mainly performed using the serum creatinine (SC) level, Doppler ultrasound (US), or renal biopsy. Recently proposed diffusion-based magnetic resonance imaging (MRI) methods have been explored as new, non-invasive tools for assessing renal function after transplantation. Purpose To investigate the value of fractional anisotropy (FA) measurements in the evaluation of acute rejection cases after renal transplant. Material and Methods Doppler US and MRI diffusion tensor imaging (DTI) were performed in 21 patients with graft dysfunction requiring graft biopsy after renal transplantation and in 21 patients with normal graft function. The MR examinations were performed on a 1.5-T MRI using two b-values (0 and 800 s/mm2). FA values were measured from the cortex and medulla of the transplanted kidney at the upper, middle, and lower poles. Results Twenty-one transplant patients diagnosed with acute rejection (Group 1) were compared to the control group of 21 transplant patients with normal graft function (Group 2). The measured FA values of the medulla were 0.19 ± 0.02 and 0.22 ± 0.05 ( P = 0.017) for Groups 1 and 2, respectively. On the other hand, the measured FA values of the renal cortex were 0.18 ± 0.04 and 0.18 ± 0.04 ( P = 0.97) for Groups 1 and 2, respectively. Conclusion The good correlation between the renal medulla FA values and allograft function shows that MR DTI has potential for non-invasive functional assessment of transplanted kidneys. On the other hand, the renal cortex FA values had no correlation with the allograft function.

Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation

2013 ◽  
Vol 27 (4) ◽  
pp. E424-E430 ◽  
Author(s):  
Justin Parekh ◽  
Garrett R. Roll ◽  
Sandy Feng ◽  
Claus U. Niemann ◽  
Ryutaro Hirose
Keyword(s):  
Renal Transplantation ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function

scholarly journals Risk factors and long-term outcomes of delayed graft function in deceased donor renal transplantation

2015 ◽  
Vol 89 (4) ◽  
pp. 208 ◽  
Author(s):  
Chang Ho Seo ◽  
Jeong Il Ju ◽  
Mi-Hyeong Kim ◽  
Kang Woong Jun ◽  
Sang-Hyun Ahn ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplantation ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function ◽  
Long Term Outcomes

scholarly journals Accelerated Oxalosis Contributing to Delayed Graft Function after Renal Transplantation

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Yvelynne P. Kelly ◽  
Astrid Weins ◽  
Melissa Y. Yeung
Keyword(s):  
Renal Transplantation ◽  
Acute Tubular Necrosis ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function ◽  
Tubular Necrosis ◽  
Oxalate Crystals ◽  
Allograft Biopsy ◽  
Timely Fashion ◽  
Therapeutic Measures

Hyperoxaluria is an important and underrecognized cause for allograft dysfunction and loss after transplantation. It is potentially treatable if recognized in a timely fashion. Research is ongoing to expand the array of therapeutic options available to treat this. We present a case of a 59-year-old gentleman who underwent deceased donor renal transplantation that was complicated by delayed graft function necessitating continuation of renal replacement therapy. His initial biopsy showed extensive acute tubular necrosis with associated peritubular capillaritis and interstitial nephritis and oxalate crystals in several tubules. Despite receiving methylprednisolone to treat moderate acute cellular rejection, he remained dialysis dependent with minimal urine output. An interval renal allograft biopsy revealed residual acute tubular necrosis with extensive oxalate crystals now visible in many tubules. His plasma oxalate level was concurrently elevated to 19.3 μmol/L (reference range ≤ 1.9 μmol/L). He commenced calcium citrate to manage his hyperoxaluria and ultimately became dialysis independent at 3 weeks after transplantation. This case provides an important example of accelerated oxalate nephropathy as an underappreciated contributor to delayed graft function after renal transplantation. Our accompanying discussion provides an update on current therapeutic measures for managing this challenging condition.

Arteriolar Hyalinization Predicts Delayed Graft Function in Deceased Donor Renal Transplantation

2008 ◽  
Vol 86 (7) ◽  
pp. 1002-1005 ◽  
Author(s):  
Marie Matignon ◽  
Dominique Desvaux ◽  
Laure-Hélène Noël ◽  
Françoise Roudot-Thoraval ◽  
Eric Thervet ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function

Non-Invasive Distinction of Non-Alcoholic Fatty Liver Disease using Urinary Volatile Organic Compound Analysis: Early Results

2015 ◽  
Vol 24 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Ramesh P. Arasaradnam ◽  
Michael McFarlane ◽  
Emma Daulton ◽  
Erik Westenbrink ◽  
Nicola O’Connell ◽  
...  
Keyword(s):  
Liver Disease ◽  
Pilot Study ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diagnostic Methods ◽  
Screening Methods ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Volatile Organic ◽  
Alcoholic Fatty Liver Disease

Background & Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) is the commonest cause of chronic liver disease in the western world. Current diagnostic methods including Fibroscan have limitations, thus there is a need for more robust non-invasive screening methods. The gut microbiome is altered in several gastrointestinal and hepatic disorders resulting in altered, unique gut fermentation patterns, detectable by analysis of volatile organic compounds (VOCs) in urine, breath and faeces. We performed a proof of principle pilot study to determine if progressive fatty liver disease produced an altered urinary VOC pattern; specifically NAFLD and Non-Alcoholic Steatohepatitis (NASH).Methods: 34 patients were recruited: 8 NASH cirrhotics (NASH-C); 7 non-cirrhotic NASH; 4 NAFLD and 15 controls. Urine was collected and stored frozen. For assay, the samples were defrosted and aliquoted into vials, which were heated to 40±0.1°C and the headspace analyzed by FAIMS (Field Asymmetric Ion Mobility Spectroscopy). A previously used data processing pipeline employing a Random Forrest classification algorithm and using a 10 fold cross validation method was applied.Results: Urinary VOC results demonstrated sensitivity of 0.58 (0.33 - 0.88), but specificity of 0.93 (0.68 - 1.00) and an Area Under Curve (AUC) 0.73 (0.55 -0.90) to distinguish between liver disease and controls. However, NASH/NASH-C was separated from the NAFLD/controls with a sensitivity of 0.73 (0.45 - 0.92), specificity of 0.79 (0.54 - 0.94) and AUC of 0.79 (0.64 - 0.95), respectively.Conclusions: This pilot study suggests that urinary VOCs detection may offer the potential for early non-invasive characterisation of liver disease using 'smell prints' to distinguish between NASH and NAFLD.

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