scholarly journals The Effect of Oral Nifedipine versus Parenteral Magnesium Sulfate and Ritodrine for Tocolysis in Patients with Threatened Preterm Labor: A Randomized Controlled Trial

2019 ◽  
Vol 09 (08) ◽  
pp. 1142-1150
Author(s):  
Safwat A. Salman ◽  
Dina Habib ◽  
Mohamed Atef ◽  
Ahmed M. Abbas
Keyword(s):  
Randomized Controlled Trial ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Threatened Preterm Labor

Magnesium Sulfate Compared with Nifedipine for Acute Tocolysis of Preterm Labor: A Randomized Controlled Trial

2007 ◽  
Vol 62 (11) ◽  
pp. 696-697
Author(s):  
Deirdre J. Lyell ◽  
Kristen Pullen ◽  
Laura Campbell ◽  
Suzanne Ching ◽  
Maurice L. Druzin ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Magnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Yasuyuki Kawagoe ◽  
Hiroshi Sameshima ◽  
Tsuyomu Ikenoue ◽  
Ichiro Yasuhi ◽  
Tatsuhiko Kawarabayashi
Keyword(s):  
Randomized Controlled Trial ◽  
Combination Therapy ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Uterine Contraction ◽  
Controlled Trial ◽  
Second Line ◽  
Uterine Contractions ◽  
Randomized Controlled ◽  
Tocolytic Agent

Objectives. We evaluated the efficacy of magnesium sulfate as a second-line tocolysis for 48 hours.Materials and Methods. A multi-institutional, simple 2-arm randomized controlled trial was performed. Forty-five women at 22 to 34 weeks of gestation were eligible, whose ritodrine did not sufficiently inhibit uterine contractions. After excluding 12 women, 33 were randomly assigned to either magnesium alone or combination (ritodrine and magnesium). The treatment was determined as effective if the frequency of uterine contraction was reduced by 30% at 48 hours of the treatment.Results. After magnesium sulfate infusion, 90% prolonged their pregnancy for >48 hours. Combination therapy was effective in 95% (18/19), which was significantly higher than 50% (7/14) for magnesium alone.Conclusion. This randomized trial revealed that combination therapy significantly reduced uterine contractions, suggesting that adjuvant magnesium with ritodrine is recommended, rather than changing into magnesium alone, when uterine contractions are intractable with ritodrine infusion.

Cervical Length Measurements in the Management of Threatened Preterm Labor: A Randomized Controlled Trial

2020 ◽  
Vol 103 (10) ◽  
pp. 964-970
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Labor ◽  
Neonatal Outcome ◽  
Controlled Trial ◽  
Preterm Births ◽  
Cervical Length ◽  
Randomized Controlled ◽  
Measurement Protocol ◽  
Significant Difference ◽  
Threatened Preterm Labor

Objective: To compare the obstetrics and neonatal outcome of a protocol using the cervical length (CL) measurement with a traditional protocol without CL measurement in the management of threatened preterm labor. Materials and Methods: The present randomized controlled trial was carried out in Udonthani Hospital between November 2018 and August 2019. One hundred sixteen preterm pregnant women randomly allocated into either a CL group (n=58) or a non-CL group (n=58) were included in this study. CL of less than 3 cm and persistent contractions after one to two hours rest were indications for tocolytic treatment. The proportion of preterm births within 48 hours after treatment, the proportion of tocolytic using cases, and the obstetrics and neonatal outcomes were compared between the groups. Results: Out of the 58 women in the CL group, 39.7% had a CL of less than 3 cm. Delivery within 48 hours occurred in 8.6% of the CL group compared with 15.5% in the non-CL group, which was not statistically significant. Tocolytic drug was given to 65.5% in the CL group compared with 94.8% in non-CL group (p<0.01). The participants were followed up until delivery and 55 women in the CL group and 57 women in the non-CL group completed the present study. Preterm delivery rate was 36.4% in the CL group compared with 36.8% in the non-CL group (p>0.05). There was no significant difference for the mean gestational age at delivery and neonatal complications for both groups. Conclusion: CL measurement protocol did not improve the neonatal outcome of threatened preterm labor. However, it reduced unnecessary tocolytic treatment and its associated complication. Keywords: Cervical length, Threatened preterm labor, Preterm labor, Tocolysis, Randomized trial

Magnesium Sulfate Compared With Nifedipine for Acute Tocolysis of Preterm Labor: A Randomized-controlled Trial

2008 ◽  
Vol 28 (1) ◽  
pp. 21-22
Author(s):  
D.J. Lyell ◽  
K. Pullen ◽  
L. Campbell ◽  
S. Ching ◽  
M.L. Druzin ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Magnesium Sulfate ◽  
Preterm Labor ◽  
Controlled Trial ◽  
Randomized Controlled
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