scholarly journals Recurrent Giant Cell Tumor of the Distal End Radius: A Case Report and Surgical Treatment with Wide Resection and Reconstruction with Non-Vascularised Autologous Proximal Fibular Graft

2014 ◽  
Vol 04 (11) ◽  
pp. 285-291 ◽  
Author(s):  
Venkatesh Gupta ◽  
Vijaya Kumar
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Wide Resection ◽  
Fibular Graft ◽  
Recurrent Giant Cell Tumor

scholarly journals Multiple Pulmonary Metastases of Giant Cell Tumor of Bone with expression of VEGFR-2 Successfully Treated by Denosumab and Apatinib: A Rare Case Report

2021 ◽  
Author(s):  
taojun gong ◽  
Yi Luo ◽  
Yitian Wang ◽  
Chuanxi Zheng ◽  
Jianguo Fang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Local Recurrence ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Pulmonary Metastases ◽  
Cell Tumor ◽  
Wide Resection ◽  
High Tendency ◽  
Bony Destruction

Abstract Background: Giant cell tumor of bone (GCTB) is a rare benign but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the occurrence of lung metastasis. Currently, the treatment of pulmonary metastases of GCTB is controversial. Denosumab is the preferred regimen for unresectable metastatic lesions, but there are no alternative treatment options when denosumab is resistant. So far, no case reports of metastatic GCTB treated with denosumab and apatinib have been published. Case presentation: This is a case report of a 26-year-old female who experienced right knee pain for over 6 months. Radiography and computed tomography revealed osteolytic bony destruction in the proximal right tibia. Using histological, radiological, and clinical techniques, a diagnosis of GCTB was achieved. Meanwhile, the immunohistochemical stain-identified the tumor cells were positive for vascular endothelial growth factor receptor 2 (VEGFR-2). After intralesional curettage of the primary tumor and wide resection of local recurrence surgeries, she developed recurrent hemoptysis. Chest computed tomography (CT) images showed multiple pulmonary nodules. She was administrated denosumab therapy but disease progression was confirmed after four months of treatment. She then received denosumab and apatinib therapy for 24 months, after a partial response was achieved.Conclusions: We depict a case of multiple pulmonary metastases of GCTB successfully controlled by denosumab and apatinib therapy. VEGFR-2 may be an effective therapeutic target for GCTB with pulmonary metastasis when denosumab is ineffective.

EXCISION OF GIANT CELL TUMOR FOLLOWED BY RECONSTRUCTION OF DISTAL RADIUS USING FREE VASCULARIZED FIBULAR GRAFT

2019 ◽  
Vol 1 (4) ◽  
Author(s):  
Prisca Oriana Sutanto ◽  
Agus Roy Rusli Hamid ◽  
Adinda Putra Pradhana
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Distal Radius ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Wide Resection ◽  
Fibular Graft ◽  
Maximum Function ◽  
Vascularized Fibular Graft ◽  
Free Vascularized Fibular Graft

Giant cell tumor (GCT) of the distal radius is a rare and unpredictable lesion. The aim of treatment is complete removal of the tumor and preservation of the maximum function of the extremity. Lower rates of local recurrence have been noted after wide resection of the diseased bone. Its standard treatment has ranged from surgical curettage to wide resection. One method for closing the defect is using the head of the fibula as a substitute for the distal radius. The healing of vascularized fibular graft is very quick and without bone resorption. Thus, in the procedure for reconstruction and limb salvage after bone tumor resection of the distal radius, the free vascularized fibular graft with the fibular head is an ideal substitute. This case report will show a patient with GCT that successfully treated by an excision of GCT followed by reconstruction of distal radius using free vascularized fibular graft.

The outcome of surgical treatment for recurrent giant cell tumor in the appendicular skeleton

2012 ◽  
Vol 17 (4) ◽  
pp. 464-469 ◽  
Author(s):  
Rong Wan ◽  
Weibin Zhang ◽  
Jianqiang Xu ◽  
Ping Hao ◽  
Yaoqi Yang ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Appendicular Skeleton ◽  
Recurrent Giant Cell Tumor

Microsurgical fibular graft for full-length radius reconstruction after giant-cell tumor resection: A case report

Microsurgery ◽  
2005 ◽  
Vol 25 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Guang-Rong Yu ◽  
Feng Yuan ◽  
Shi-Min Chang ◽  
William C. Lineaweaver ◽  
Feng Zhang
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Full Length ◽  
Fibular Graft

scholarly journals Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature

2021 ◽  
Vol 11 ◽  
Author(s):  
Wenxiang Zhang ◽  
Xiangyi Kong ◽  
Yihang Qi ◽  
Xiangyu Wang ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Tumor ◽  
Breast Tumor ◽  
Lung Metastases ◽  
Left Breast ◽  
Cell Tumor

Giant cell tumor of soft tissue (GCT-ST) is an extremely rare tumor that is similar in morphology and immunohistochemistry to giant cell tumor of the bone. Almost 80% of these tumors occur in the upper and lower extremities, and the breast is a very rare location. Here, we report a case of a 65-year-old female patient with a small mobile palpable lump in the left breast. Although the left breast tumor was considered malignant on preoperative imaging, no evidence of malignant tumor was found by ultrasound-guided core needle biopsy (CNB). Subsequently, the left breast tumor was confirmed as a malignant tumor by intraoperative rapid pathological examination. The initial treatment of the tumor was wide local excision and sentinel lymph node biopsy, and it was confirmed to be GCT-ST by histopathology and immunohistochemistry. Despite surgical treatment achieving clear surgical margins, the patient experienced lung metastases within a year of her initial treatment. Fortunately, the patient underwent surgical treatment of lung metastases, and at the last follow-up, the patient was still alive. This is the first case of a primary soft tissue tumor of the breast that has undergone surgical intervention after lung metastasis. This case report highlights the complexity of the clinical diagnosis and treatment of GCT-ST arising from the breast. Surgery may be another good treatment when the patient develops lung metastases.

scholarly journals A recurrent giant cell tumor of bone treated with denosumab: a case report

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Nicola Stadler ◽  
Thomas Fingernagel ◽  
Stefan G. Hofstaetter ◽  
Klemens Trieb
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Recurrent Giant Cell Tumor
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