scholarly journals Fatal septic shock caused by candida myocarditis associated with malignant lymphoma and Epstein-Barr virus mediated disorder

2011 ◽  
Vol 01 (02) ◽  
pp. 24-28
Author(s):  
Salah A. M. Said ◽  
Bart J. F. Liebrand ◽  
Nersing Bansraj ◽  
Erik Eijken
Keyword(s):  
Septic Shock ◽  
Malignant Lymphoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Giorgio Berlot ◽  
Ariella Tomasini ◽  
Lorenzo Zandonà ◽  
Eugenio Leonardo ◽  
Rossana Bussani ◽  
...  
Keyword(s):  
Septic Shock ◽  
Infectious Mononucleosis ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Multiple Organ ◽  
Aggressive Lymphoma ◽  
Systemic Involvement ◽  
Barr Virus ◽  
Epstein Barr ◽  
Clinical Pictures

The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered.

scholarly journals Epstein-Barr virus associated posttransplant malignant lymphoma in renal allograft recipients

1994 ◽  
Vol 9 (2) ◽  
pp. 162
Author(s):  
Yeong Jin Choi ◽  
Chang Suk Kang ◽  
Wan Shik Shin ◽  
Mi Kyoung Jee ◽  
Byoung Kee Kim ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Epstein Barr Virus ◽  
Renal Allograft ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Expression of Epstein-Barr virus in malignant lymphoma.

1994 ◽  
Vol 34 (6) ◽  
pp. 313-318
Author(s):  
Masayoshi Tokunaga ◽  
Noriko Yamamoto ◽  
Yoshiko Uemura ◽  
Tetsuhiko Itoh ◽  
Yasuhiro Hamasaki ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals SARS-Cov2 enables anaerobic bacteria (Prevotella, et al) to colonize the lungs disrupting homeostasis, causing long-drawn chronic symptoms, and acute severe symptoms (ARDS, septic shock, clots, arterial stroke) which finds resonance, with key differences, in the ‘forgotten disease’ Lemierre Syndrome, enabled by Epstein Barr Virus

2020 ◽  
Author(s):  
Sandeep Chakraborty
Keyword(s):  
Septic Shock ◽  
Calcium Binding ◽  
Epstein Barr Virus ◽  
Anaerobic Bacteria ◽  
Lemierre Syndrome ◽  
Barr Virus ◽  
Lung Sample ◽  
Initial Symptoms ◽  
Epstein Barr ◽  
Bacterial Genes

Metagenomic studies of Covid19 patient sequencing data from different countries (China, Brazil, Peru, Cambodia, USA) shows a pattern that SARS-Cov2 enables anaerobic bacteria (eg Prevotella, Veil- lonella, Capnocytophaga, Fusobacterium, Oribacterium and Bacteroides) colonize the lungs, disrupting the homeostasis found in healthy patients. Long drawn symptoms in Covid19 have caused great con- sternation, and could be explained by persistence of biofilms. Some of these bacteria are implicated in increasing IL-6, cause ground glass opacity in lungs and are associated with cardiac injury - all symp- toms associated with Covid19. Many studies also show several bacterial infection markers - like D-dimer, LDH, C-reactive protein and ferritin - being significantly high, while the viral immune response is at- tenuated (reported by three studies till date). This is also confirmed here in the lung sample from a 74 year old deceased patient, showing high levels of IFITM3, ferritin and S100 calcium binding protein. Anaerobic bacteria causing initial symptoms like persistent fever, chills, pain and later symptoms like ARDS, blood clots, arterial stroke and septic shock finds resonance in a ”forgotten disease” - Lemierre syndrome (LS). While, LS is enabled by Epstein Barr Virus - possibly by ‘a transient depression of T cell immunity’, two recent studies show that IFN-λ might promote bacterial superinfection in Covid19. Also, 16S rRNA bacterial genes and endotoxins (LPS) were discovered in 18/19 severely ill pneumonia patients in one study, suggesting dissemination of endotoxins, and not actual bacteria, might suffice to cause severity. Autopsies also show foci of acute bronchopneumonia. There are key differences with LS - for example origin of LS is the jugular vein while Covid19 starts in the lungs (and this difference should result in Covid19 to be easier to treat). Co-infection of EBV and SARS-Cov2 leads to greater symptoms (fever, higher CRP) in a study of 67 patients. SARS-2003 showed a lot of similar symptoms, which did not get enough media attention. There was a specific warning issued in 2004 for ‘an increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks’. Enhanced pathogen testing kits, which include RT-PCT for bacterial genes and endotoxin tests, could confirm this disruption in Covid19, and thus anaerobic-specific antibiotics could significantly help in therapy.

Coexistence of Epstein–Barr virus-associated gastric carcinoma with malignant lymphoma: report of two cases

2006 ◽  
Vol 449 (2) ◽  
pp. 215-219 ◽  
Author(s):  
Tetsuya Ueo ◽  
Kenji Kashima ◽  
Tsutomu Daa ◽  
Yoshiyuki Kondo ◽  
Shigeo Yokoyama
Keyword(s):  
Gastric Carcinoma ◽  
Malignant Lymphoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Contribution of Epstein-Barr virus to development of malignant lymphoma of the thyroid

1995 ◽  
Vol 45 (5) ◽  
pp. 366-374 ◽  
Author(s):  
Kenji Takahashi ◽  
Kenji Kashima ◽  
Tsutomu Daa ◽  
Shigeo Yokoyama ◽  
Iwao Nakayama ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
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