scholarly journals A Case of Ectopic Growth Hormone Releasing Hormone (GHRH) from Pancreatic Neuroendocrine Tumor Resistant to Therapy

2013 ◽  
Vol 03 (07) ◽  
pp. 271-275
Author(s):  
Ohoud Almohareb ◽  
Juan Rivera
Keyword(s):  
Growth Hormone ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone

Ectopic Acromegaly Due to a Pancreatic Neuroendocrine Tumor Producing Growth Hormone-Releasing Hormone

2011 ◽  
Vol 17 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Danielle Weiss ◽  
Hannes Vogel ◽  
M. Lopes ◽  
Steven Chang ◽  
Laurence Katznelson
Keyword(s):  
Growth Hormone ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Ectopic Acromegaly

Ectopic Growth Hormone-Releasing Hormone Secretion by a Neuroendocrine Tumor Causing Acromegaly: Long-Term Follow-Up Results

2009 ◽  
Vol 20 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Neşe Colak Ozbey ◽  
Yersu Kapran ◽  
Alp Bozbora ◽  
Yeşim Erbil ◽  
Cemil Tascioglu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Neuroendocrine Tumor ◽  
Hormone Secretion ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Follow Up

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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