scholarly journals Oxidative Stress and Antioxidant Status in Acute and Chronic Myeloid Leukemia Patients

2013 ◽  
Vol 03 (03) ◽  
pp. 17-22 ◽  
Author(s):  
Ullagaddi Rajeshwari ◽  
Iyer Shobha ◽  
Rao Raghunatha ◽  
Bondada Andallu
Keyword(s):  
Oxidative Stress ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Antioxidant Status

scholarly journals Protein Damage and Antioxidant Status Alterations Caused by Oxidative Injury in Chronic Myeloid Leukemia

2016 ◽  
Vol 27 (2) ◽  
pp. 55 ◽  
Author(s):  
Deepti Pande ◽  
Reena Negi ◽  
Ranjana S. Khanna ◽  
Hari D. Khanna
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Chronic Myeloid Leukemia ◽  
Glutathione Peroxidase ◽  
Myeloid Leukemia ◽  
Antioxidant Status ◽  
Philadelphia Chromosome ◽  
Thiobarbituric Acid ◽  
Protein Carbonyl ◽  
Cellular Damage

Objective: To evaluate the oxidative stress and antioxidant defense in patients with chronic myeloid leukemia.Background: Chronic myeloid leukemia is a myeloproliferative disorder associated with a characteristic chromosomal translocation called the Philadelphia chromosome. Reactive oxygen species and other free radicals mediate phenotypic and genotypic changes leading from mutation to neoplasia in all cancers, including chronic myeloid leukemia. We evaluated patients with chronic myeloid leukemia by observing their oxidative status and antioxidant defense.Methods: Using serum from 40 clinically diagnosed cases of chronic myeloid leukemia as well as 40 healthy controls, we measured the concentration of thiobarbituric acid, levels of protein carbonylation, total antioxidant status, catalase, superoxide dismutase, glutathione peroxidase, vitamins A and E, and the trace elements zinc, magnesium, and selenium. Results: We found significantly increased levels of serum malonyldialdehyde and protein carbonyl in patients with chronic myeloid leukemia in comparison to healthy individuals, and significantly decreased levels of the antioxidants and micronutrients thiobarbituric acid, catalase, superoxide dismutase, glutathione peroxidase, vitamins A and E, zinc, magnesium, and selenium. These data suggest cellular damage occurring at the level of lipids and proteins.Conclusion: These findings indicate a link between low levels of antioxidants and cellular damage in patients with chronic myeloid leukemia, supporting the idea that oxidative stress may play a role in the pathogenesis of chronic myeloid leukemia.

scholarly journals Oxidative stress and antioxidant status in patients with chronic myeloid leukemia

2008 ◽  
Vol 23 (4) ◽  
pp. 328-333 ◽  
Author(s):  
Rizwan Ahmad ◽  
Anil K. Tripathi ◽  
Payal Tripathi ◽  
Ranjana Singh ◽  
Sushma Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Antioxidant Status

scholarly journals The Involvement of Oxidative Stress in Chronic Myeloid Leukemia

2020 ◽  
Vol 25 (1) ◽  
pp. 1267-1274
Author(s):  
EMILIA GEORGIANA PASCU ◽  
◽  
MIHNEA-ALEXANDRU GĂMAN ◽  
CORNEL MOISĂ ◽  
ALEXANDRU DAN ASSANI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia

scholarly journals Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

2012 ◽  
Vol 34 (5) ◽  
pp. 352-355 ◽  
Author(s):  
Maria Juracy Petrola ◽  
Alana Joselina Montenegro de Castro ◽  
Maria Helena da Silva Pitombeira ◽  
Maritza Cavalcante Barbosa ◽  
Acy Telles de Souza Quixadá ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Serum Concentrations ◽  
Markers Of Oxidative Stress

scholarly journals Relationship between Oxidative Stress and Imatinib Resistance in Model Chronic Myeloid Leukemia Cells

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 610
Author(s):  
Sylwester Głowacki ◽  
Ewelina Synowiec ◽  
Marzena Szwed ◽  
Monika Toma ◽  
Tomasz Skorski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Protein A ◽  
Mitochondrial Potential ◽  
Imatinib Resistance ◽  
Ros Accumulation ◽  
Ros Metabolism

Chronic myeloid leukemia (CML) develops due to the presence of the BCR-ABL1 protein, a target of tyrosine kinase inhibitors (TKIs), such as imatinib (IM), used in a CML therapy. CML eradication is a challenge due to developing resistance to TKIs. BCR-ABL1 induces endogenous oxidative stress leading to genomic instability and development of TKI resistance. Model CML cells susceptible or resistant to IM, as well as wild-type, non-cancer cells without the BCR-ABL1 protein were treated with IM, hydrogen peroxide (H2O2) as a model trigger of external oxidative stress, or with IM+H2O2. Accumulation of reactive oxygen species (ROS), DNA damage, activity of selected antioxidant enzymes and glutathione (GSH), and mitochondrial potential (MMP) were assessed. We observed increase in ROS accumulation in BCR-ABL1 positive cells and distinct levels of ROS accumulation in IM-susceptible cells when compared to IM-resistant ones, as well as increased DNA damage caused by IM action in sensitive cells. Depletion of GSH levels and a decreased activity of glutathione peroxidase (GPx) in the presence of IM was higher in the cells susceptible to IM. IM-resistant cells showed an increase of catalase activity and a depletion of MMP. BCR-ABL1 kinase alters ROS metabolism, and IM resistance is accompanied by the changes in activity of GPx, catalase, and alterations in MMP.

scholarly journals Studies on biomarkers for oxidative stress in patients with chronic myeloid leukemia

2009 ◽  
Vol 2 (1) ◽  
pp. 285-288 ◽  
Author(s):  
Raj K. Singh ◽  
Anil K. Tripathi ◽  
Payal Tripathi ◽  
Sushma Singh ◽  
Ranjana Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Biomarkers For Oxidative Stress
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