scholarly journals Why Labor Epidural Causes Fever and Why Lidocaine Burns on Injection? Role of TRPV 1 Receptor in Hyperthermia: Possible Explanation of Mechanism of Hyperthermia during Labor Epidural and Burning Sensation on Injection of Local Anesthetics

2012 ◽  
Vol 02 (04) ◽  
pp. 134-137 ◽  
Author(s):  
I. Kozlov
Keyword(s):  
Local Anesthetics ◽  
Burning Sensation ◽  
Labor Epidural

scholarly journals Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xiaoqing Fan ◽  
Haoran Yang ◽  
Chenggang Zhao ◽  
Lizhu Hu ◽  
Delong Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Western Blot ◽  
Local Anesthetics ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Xenograft Model ◽  
Cell Counting ◽  
Migration And Invasion ◽  
Self Renewal

Abstract Background A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local anesthetics in cancer stem cells. This study aimed to determine the possible role of local anesthetics in glioblastoma stem cell (GSC) self-renewal and the underlying molecular mechanisms. Methods The effects of local anesthetics in GSCs were investigated through in vitro and in vivo assays (i.e., Cell Counting Kit 8, spheroidal formation assay, double immunofluorescence, western blot, and xenograft model). The acyl-biotin exchange method (ABE) assay was identified proteins that are S-acylated by zinc finger Asp-His-His-Cys-type palmitoyltransferase 15 (ZDHHC15). Western blot, co-immunoprecipitation, and liquid chromatograph mass spectrometer-mass spectrometry assays were used to explore the mechanisms of ZDHHC15 in effects of local anesthetics in GSCs. Results In this study, we identified a novel mechanism through which local anesthetics can damage the malignant phenotype of glioma. We found that local anesthetics prilocaine, lidocaine, procaine, and ropivacaine can impair the survival and self-renewal of GSCs, especially the classic glioblastoma subtype. These findings suggest that local anesthetics may weaken ZDHHC15 transcripts and decrease GP130 palmitoylation levels and membrane localization, thus inhibiting the activation of IL-6/STAT3 signaling. Conclusions In conclusion, our work emphasizes that ZDHHC15 is a candidate therapeutic target, and local anesthetics are potential therapeutic options for glioblastoma.

Role of the carbonyl group of local anesthetics in their anesthetic effect

1972 ◽  
Vol 73 (5) ◽  
pp. 553-556
Author(s):  
V. M. Belobrov ◽  
I. V. Komissarov ◽  
L. E. Makarova ◽  
N. Z. Rudenko ◽  
E. V. Titov
Keyword(s):  
Carbonyl Group ◽  
Local Anesthetics ◽  
Anesthetic Effect

scholarly journals Correlation between the increased release of catecholamines evoked by local anesthetics and their analgesic and adverse effects: Role of K + channel inhibition

2016 ◽  
Vol 124 ◽  
pp. 21-26 ◽  
Author(s):  
Carmen Sircuta ◽  
Alexandra Lazar ◽  
Leonard Azamfirei ◽  
Mária Baranyi ◽  
E. Sylvester Vizi ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Local Anesthetics ◽  
K Channel ◽  
Channel Inhibition

scholarly journals Neisseria Gonorrheae: A Cause of Male Infertility

2021 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Bitet DE
Keyword(s):  
Male Infertility ◽  
Burning Sensation ◽  
Semen Parameters ◽  
Laboratory Studies ◽  
Sperm Production ◽  
Transmitted Infection ◽  
Laboratory Methods ◽  
Sexually Transmitted ◽  
Sperm Antibodies

Background: Gonorrhoea is a sexually transmitted infection that is commonly related to male infertility. The infection affects sperm transport through the urinary tract and subsequent damage of the testicular tubes. The infection also impair sperm production as the infection is rarely asymptomatic and can be difficult to diagnose, it is possible that its contribution to male infertility is underestimated. Infection of the genitals results in a purulent (pus-like) discharge from the genitals which may be foul smelling, inflammation, redness, swelling, dysuria, and a burning sensation during urination. As with Chlamydia, it is possible to have a Gonorrhea infection without noticeable symptoms, and which can cause permanent scarring and blockage in the sperm production duct. Gonorrhoea is a bacterial infection and is treatable with antibiotics. Laboratory studies reveal that N. gonorrhoeae infection can impair motility, viability and spermatogenesis; increase anti-sperm antibodies are associated with a decrease in semen parameters as a result of the production of anti-sperm antibodies in the genital tract. Aim: The study aimed at reviewing the possible role of gonorrhoea in male infertility. Method: Research publications such as Pubmed, Scopus, Medline etc. Results: over 115 journals of international repute were obtained, out of which 50 were found to be closely relevant such as; the implication of N. gonorrheae in male infertility, complication of N. gonorrhea infection, N. gonorrhea e and male infertility and were reviewed. Conclusion: N. gonorrhoae was found implicative in male infertility and the need for comprehensive modern laboratory methods for the diagnosis of the infection and also to included routine laboratory tests.

scholarly journals A ROLE OF VIRECHANA IN SHEETAPITTA- A CASE STUDY

2018 ◽  
Vol 6 (07) ◽  
Author(s):  
Kavya Ramrao Kadapi ◽  
Devashis Biswas
Keyword(s):  
Burning Sensation ◽  
Cold Climate ◽  
Urticaria Pigmentosa ◽  
Exposure To Cold

A 45-years old female, presented with complaints of Reddish lesions in the both the limbs on and off since 1 moth associated with Burning sensation, pain ,itching aggravating more during evening hours and on exposure to cold climate . Diagnosed as Sheeta-Pittavis-à-vis Urticaria Pigmentosa. Its management was successfully done by following the principle of Shodhana The purpose of this paper was to justify how a clinical hypothesis based on appropriate diagnosis  of Dosha – Dushya along with scrutinizing magnitude of the shodhana therapy alone would help in curing the condition by using the principle of purificatory treatment.

Evolving Role of Local Anesthetics in Managing Postsurgical Analgesia

2015 ◽  
Vol 37 (6) ◽  
pp. 1354-1371 ◽  
Author(s):  
Julie Golembiewski ◽  
Joseph Dasta
Keyword(s):  
Local Anesthetics
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