scholarly journals Metal Ion Release of Manufactured Metal Oxide Nanoparticles Is Involved in the Allergic Response to Inhaled Ovalbumin in Mice

2016 ◽  
Vol 04 (02) ◽  
pp. 17-26 ◽  
Author(s):  
Masanori Horie ◽  
Mayumi Stowe ◽  
Miki Tabei ◽  
Etsushi Kuroda
2021 ◽  
Vol 12 ◽  
Author(s):  
Sung-Hyun Kim ◽  
Jin Hee Lee ◽  
Kikyung Jung ◽  
Jun-Young Yang ◽  
Hyo-Sook Shin ◽  
...  

Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to nanomaterials. In this study, we evaluated the skin sensitization of nanomaterials comparing metal haptens in vivo and in vitro. We selected five metal oxide NPs, containing copper oxide, cobalt monoxide, cobalt oxide, nickel oxide, or titanium oxide, and two types of metal chlorides (CoCl2 and CuCl2), to compare the skin sensitization abilities between NPs and the constituent metals. The materials were applied to KeratinoSensTM cells for imitated skin-environment setting, and luciferase induction and cytotoxicity were evaluated at 48 h post-incubation. In addition, the response of metal oxide NPs was confirmed in lymph node of BALB/C mice via an in vivo method. The results showed that CuO and CoO NPs induce a similar pattern of positive luciferase induction and cytotoxicity compared to the respective metal chlorides; Co3O4, NiO, and TiO2 induced no such response. Collectively, the results implied fast-dissolving metal oxide (CuO and CoO) NPs release their metal ion, inducing skin sensitization. However, further investigations are required to elucidate the mechanism underlying NP-induced skin sensitization. Based on ion chelation data, metal ion release was confirmed as the major “factor” for skin sensitization.


Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3446
Author(s):  
Mohammed Zahedul Islam Nizami ◽  
Veena W. Xu ◽  
Iris X. Yin ◽  
Ollie Y. Yu ◽  
Chun-Hung Chu

Nanoparticles based on metal and metallic oxide have become a novel trend for dental use as they interfere with bacterial metabolism and prevent biofilm formation. Metal and metal oxide nanoparticles demonstrate significant antimicrobial activity by metal ion release, oxidative stress induction and non-oxidative mechanisms. Silver, zinc, titanium, copper, and magnesium ions have been used to develop metal and metal oxide nanoparticles. In addition, fluoride has been used to functionalise the metal and metal oxide nanoparticles. The fluoride-functionalised nanoparticles show fluoride-releasing properties that enhance apatite formation, promote remineralisation, and inhibit demineralisation of enamel and dentine. The particles’ nanoscopic size increases their surface-to-volume ratio and bioavailability. The increased surface area facilitates their mechanical bond with tooth tissue. Therefore, metal and metal oxide nanoparticles have been incorporated in dental materials to strengthen the mechanical properties of the materials and to prevent caries development. Another advantage of metal and metal oxide nanoparticles is their easily scalable production. The aim of this study is to provide an overview of the use of metal and metal oxide nanoparticles in caries prevention. The study reviews their effects on dental materials regarding antibacterial, remineralising, aesthetic, and mechanical properties.


2016 ◽  
Vol 75 (2) ◽  
pp. 462-473 ◽  
Author(s):  
Baranidharan Sundaram ◽  
Arun Kumar

This study evaluated the influence of metal oxide nanoparticles (NPs) (Ag2O, TiO2) and their mixture on activated sludge for 180 days. When tested, a mixture of NPs at 1 and 10 mg/L had greater impact than individual NPs, in which maximum reduction in chemical oxygen demand (COD) elimination (76.3%) was observed after 150 days for 1 mg/L (500 mg/L COD concentration) and after 180 days (70.2%) for 10 mg/L (250 mg/L COD concentration). TiO2 had higher inhibition on COD reduction than Ag2O NPs at 1 and 10 mg/L. An antagonistic effect was observed in which the combination of individual NPs had a greater effect than a mixture of NPs. Reduction in COD elimination was found to be dependent on NP type and concentration (p < 0.05). Further, metal ion concentration was higher in sludge than supernatant irrespective of NPs, while microscopic analysis showed the presence of NPs inside activated sludge. Among NPs tested, the concentration of Ti4+ ion was greater in sludge than in the Ag+ ion, thus indicating that TiO2 has a greater affinity than Ag2O NPs. All three factors (NP type, NP concentration, organic concentration) play a significant role in imparting COD removal (p < 0.05). Future studies are required to quantify NP concentration to minimize NP effect on plant performance.


2013 ◽  
Vol 246 ◽  
pp. 125-136 ◽  
Author(s):  
K. Yogesh Kumar ◽  
H.B. Muralidhara ◽  
Y. Arthoba Nayaka ◽  
J. Balasubramanyam ◽  
H. Hanumanthappa

Author(s):  
Sagadevan Suresh ◽  
Selvaraj Vennila ◽  
J. Anita Lett ◽  
Is Fatimah ◽  
Faruq Mohammad ◽  
...  

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