scholarly journals Long-Term Impact in the Quality of Life of Patients with Drug-Resistant Epilepsy That Use Cannabidiol

2021 ◽  
Vol 12 (04) ◽  
pp. 103-113
Author(s):  
Gabriela Pesántez Ríos ◽  
Ignacio Pascual Pascual ◽  
Ximena Pesántez Ríos ◽  
Luciana Armijos ◽  
Estefanía Chediak ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy ◽  
Long Term Impact

scholarly journals Antiepileptic, behavioral, and antidepressant effects of adjuvant lamotrigine therapy in drug-resistant epilepsy

2004 ◽  
Vol 61 (5) ◽  
pp. 485-490 ◽  
Author(s):  
Zarko Martinovic ◽  
Nevenka Buder ◽  
Maja Milovanovic ◽  
Ruzica Velickovic
Keyword(s):  
Quality Of Life ◽  
Depression Scale ◽  
Behavioral Effects ◽  
Control Group ◽  
Life Questionnaire ◽  
Hamilton Depression Scale ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

Aim. To evaluate the behavioral effects of lamotrigine as add-on therapy in treatment-resistant epilepsy. Methods. An open, prospective, long-term study of lamotrigine as adjuvant therapy was performed in 56 patients with drug-resistant epilepsy (female/male ratio 35/21, age range 16-51 years). All the patients kept seizure diaries, and electroencephalograms were recorded at baseline and during 24 months of the treatment. Quality of life questionnaire, Hamilton depression scale (HMD), Beck depression scale (BDI), and Hamilton anxiety scale (HMA) were used before and during lamotrigine therapy. Comparative assessments were made in an age- and sex-matched control group treated with other antiepileptic drugs. Results. Overall, seizure control was improved in 55.3% of the patients, remained unchanged in 39.3%, and deteriorated in 5.4%. Improvement in some quality of life measures occurred in 50% of the patients. The HMD subscales and BDI scale showed significant improvement in lamotrigine treated patients compared to the control group (ANOVA, p < 0.01). Negative behavioral effects occurred in 10.7% of the patients. Conclusion. Lamotrigine demonstrated significant antiepileptic long-term efficacy, and its positive effects on the mood and quality of life, which surpassed the negative behavioral effects, and contributed highly to the favorable treatment outcome.

scholarly journals Long-term Impact of Adenotonsillectomy on the Quality of Life of Children with Sleep-disordered breathing

2020 ◽  
Author(s):  
Juliana Alves Sousa Caixeta ◽  
Jessica Caixeta Silva Sampaio ◽  
Vanessa Vaz Costa ◽  
Isadora Milhomem Bruno da Silveira ◽  
Carolina Ribeiro Fernandes de Oliveira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Disordered Breathing ◽  
Long Term Effects ◽  
Obstructive Sleep ◽  
Long Term Impact ◽  
Disordered Breathing

Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.

Prophylactic Total Gastrectomy: a Prospective Cohort Study of Long-Term Impact on Quality of Life

2016 ◽  
Vol 20 (12) ◽  
pp. 1950-1958 ◽  
Author(s):  
Jennifer Muir ◽  
Melyssa Aronson ◽  
Mary-Jane Esplen ◽  
Aaron Pollett ◽  
Carol J. Swallow
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Total Gastrectomy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Long Term Impact ◽  
Prophylactic Total Gastrectomy

Fifteen-minute consultation: When medicines don’t work—the child with poorly controlled seizures

2018 ◽  
Vol 104 (3) ◽  
pp. 135-140
Author(s):  
Pooja Harijan ◽  
Arnab Kumar Seal ◽  
Manish Prasad ◽  
William P Whitehouse
Keyword(s):  
Quality Of Life ◽  
Epilepsy Surgery ◽  
Drug Resistant ◽  
Algorithmic Approach ◽  
Life Management ◽  
Drug Resistant Epilepsy

Drug-resistant epilepsy (DRE) occurs in 20%–30% of children with epilepsy with significant impact on their quality of life. Management of this group of children has greatly improved in the recent years with streamlining of epilepsy surgery services and associated quaternary multimodal evaluation. This article provides a review of DRE in children and management based on recent evidence and published opinion. We have also presented an algorithmic approach to the child with possible DRE.

scholarly journals Early postoperative complications have long-term impact on quality of life after restorative proctocolectomy

Medicine ◽  
2016 ◽  
Vol 95 (27) ◽  
pp. e3966 ◽  
Author(s):  
Andrew McCombie ◽  
Yun Lee ◽  
Rutvik Vanamala ◽  
Richard Gearry ◽  
Frank Frizelle ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Postoperative Complications ◽  
Restorative Proctocolectomy ◽  
Early Postoperative Complications ◽  
Long Term Impact

scholarly journals Long-Term Impact of Sleep-Disordered Breathing on Quality of Life in Children With Obesity

2018 ◽  
Vol 14 (03) ◽  
pp. 451-458 ◽  
Author(s):  
Sherri L. Katz ◽  
Joanna E. MacLean ◽  
Nicholas Barrowman ◽  
Lynda Hoey ◽  
Linda Horwood ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Disordered Breathing ◽  
Long Term Impact ◽  
Disordered Breathing
Sign in / Sign up

Export Citation Format

Share Document