scholarly journals Antipyretic Action of Isatin and Its Analogues in Mice and Rats

2011 ◽  
Vol 02 (01) ◽  
pp. 1-5 ◽  
Author(s):  
Gyula Telegdy ◽  
Agnes Adamik ◽  
Vivette Glover
Keyword(s):  
Antipyretic Action

Central administration of alpha-MSH antiserum augments fever in the rabbit

1986 ◽  
Vol 250 (5) ◽  
pp. R803-R806 ◽  
Author(s):  
S. T. Shih ◽  
O. Khorram ◽  
J. M. Lipton ◽  
S. M. McCann
Keyword(s):  
Interleukin 1 ◽  
Rabbit Serum ◽  
Normal Rabbit Serum ◽  
Central Administration ◽  
Normal Body Temperature ◽  
Melanocyte Stimulating Hormone ◽  
Average Rise ◽  
The Brain ◽  
Antipyretic Action

alpha-Melanocyte-stimulating hormone (alpha-MSH) has a marked antipyretic action when given centrally or peripherally, and the concentration of this peptide within the septal region of the brain increases during fever. To assess the significance of endogenous central alpha-MSH in fever, antiserum was given to rabbits via a cannula implanted in the third cerebral ventricle. Each day for 3 days, the animals received 50 microliters of normal rabbit serum (NRS) or an equal volume of antiserum raised against alpha-MSH. Interleukin 1 (IL 1) was then injected intravenously to determine the effect of central immunoneutralization of alpha-MSH on the febrile response. Immunoneutralization markedly prolonged fever. The average rise in temperature and the area under the fever curve after IL 1 injection were also significantly increased. Antiserum treatment did not alter normal body temperature, and NRS had no effect on IL 1-induced fever. These results indicate that endogenous central alpha-MSH contributes to physiological limitation of fever and that the role of this peptide in temperature regulation is relevant to the febrile state but not to normothermia.

scholarly journals Antipyretic action and catalase activity

1948 ◽  
Vol 43 (1) ◽  
pp. 15-16 ◽  
Author(s):  
J. Williamson ◽  
E. A. Rudge
Keyword(s):  
Catalase Activity ◽  
Antipyretic Action

scholarly journals Nimesulide induced toxic epidermal necrolysis: a rare case report

2017 ◽  
Vol 6 (12) ◽  
pp. 2939
Author(s):  
Vineet Kumar ◽  
Manju Gari ◽  
Kishor Chakraborty ◽  
Ravi Ranjan ◽  
Anshuman Chandra ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Over The Counter ◽  
Medical Practitioners ◽  
Rare Case Report ◽  
Prescribed Medicines ◽  
Anti Fungal ◽  
Possible Cause ◽  
Antipyretic Action

Adverse drug reactions to the prescribed medicines are the major obstacles in continuation of drug treatment. Nimesulide, a selective cyclo-oxygenase (COX-2) inhibitor was first launched in Italy in 1985 and subsequently marketed in more than 50 countries including India. Due to its better and faster antipyretic action, it has gained popularity among physicians and paediatricians. Here, we report a case of 60 years old male patient who developed toxic epidermal necrolysis (TEN) following ingestion of tablet nimesulide. The patient was managed with parenteral corticosteroids, antibiotics, emollients, anti-fungal and supportive care. This case highlights the importance of nimesulide and other NSAIDs as possible cause of TEN. Nimesulide has never been approved in countries like USA, Canada, Britain, New Zealand, Australia. But in India it is available as over the counter drug and is used for various indications like fever, myalgia, arthralgia. Therefore, the drugs which are banned outside India should be used with caution and medical practitioners should report all the adverse drug reactions to such drugs. 

scholarly journals Anti-inflammatory, Analgesic Properties and Antipyretic Action of 2-Amino-1,2,3,4-tetrahydroisoquinoline-1,3-dione and Its Derivatives.

1985 ◽  
Vol 39 ◽  
pp. 192
Author(s):  
Johji Yamahara ◽  
Hideki Murakami ◽  
Tokunosuke Sawada ◽  
Hajime Fujimura ◽  
Masao Okamoto
Keyword(s):  
Anti Inflammatory ◽  
Antipyretic Action

Diclofenac Sodium versus Acetylsalicylic Acid: A Randomized Study in Febrile Patients

1986 ◽  
Vol 14 (2) ◽  
pp. 95-100 ◽  
Author(s):  
R Bettini ◽  
E Grossi ◽  
P Rapazzini ◽  
G Giardina
Keyword(s):  
High Temperature ◽  
Acetylsalicylic Acid ◽  
High Temperatures ◽  
Diclofenac Sodium ◽  
Randomized Study ◽  
Treated Group ◽  
Influenza Viruses ◽  
Antipyretic Effect ◽  
Temperature Changes ◽  
Antipyretic Action

One hundred and twenty adult patients with high temperatures (≥38°C) brought about by influenza viruses or other conditions were randomly treated with two different antipyretics: a) a 25 mg sodium diclofenac tablet (Novapirina) every 12 hours for 2 consecutive days; b) a 500 mg tablet of acetylsalicylic acid (Aspirin) every 8 hours for 2 consecutive days. Antipyretic action (assessed at 6 hours following the first administration) was found to be equally rapid and consistent in both cases but significantly longer-lasting in the Novapirina-treated group than the Aspirin-treated group (p < 0·01). Mean temperature changes over the 48 hours of observation and the over-all judgement on the antipyretic effect expressed at the end of each day of treatment were similar for both groups and good in all cases. The antiphlogistic-painkilling properties of both drugs were found to be effective in improving the symptomatology accompanying the high temperature during the course of the bout of influenza. The effectiveness/tolerability ratio was found to be satisfactory for both groups: only one case of gastric intolerance to Novapirina was recorded and five cases of gastric intolerance to Aspirin.

Antipyretic action of centrally administered arginine vasopressin but not oxytocin in the cat

1986 ◽  
Vol 385 (1) ◽  
pp. 156-160 ◽  
Author(s):  
A.M. Naylor ◽  
W.D. Ruwe ◽  
W.L. Veale
Keyword(s):  
Arginine Vasopressin ◽  
Antipyretic Action
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