scholarly journals <i>Morinda citrifolia</i> (Noni) Fruit Juice Inhibits Endocannabinoid Degradation Enzymes

2019 ◽  
Vol 07 (07) ◽  
pp. 22-34 ◽  
Author(s):  
Brett J. West ◽  
Shixin Deng ◽  
C. Jarakae Jensen
Author(s):  
Haziz Sina ◽  
Gado Dramane ◽  
Philippe Tchekounou ◽  
Mahoudo Fidèle Assogba ◽  
Kamirou Chabi-Sika ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Fernando Almeida-Souza ◽  
Noemi Nosomi Taniwaki ◽  
Ana Cláudia Fernandes Amaral ◽  
Celeste da Silva Freitas de Souza ◽  
Kátia da Silva Calabrese ◽  
...  

The search for new treatments against leishmaniasis has increased due to high frequency of drug resistance registered in endemics areas, side effects, and complications caused by coinfection with HIV.Morinda citrifoliaLinn., commonly known as Noni, has a rich chemical composition and various therapeutic effects have been described in the literature. Studies have shown the leishmanicidal activity ofM. citrifolia; however, its action on the parasite has not yet been elucidated. In this work, we analyzed leishmanicidal activity and ultrastructural changes inLeishmania infantumpromastigotes caused byM. citrifoliafruit juice treatment.M. citrifoliafruit extract showed a yield of 6.31% and high performance liquid chromatography identified phenolic and aromatic compounds as the major constituents. IC50values were 260.5 µg/mL for promastigotes and 201.3 µg/mL for intracellular amastigotes ofL. infantumtreated withM. citrifolia. Cytotoxicity assay with J774.G8 macrophages showed thatM. citrifoliafruit juice was not toxic up to 2 mg/mL. Transmission electron microscopy showed cytoplasmic vacuolization, lipid inclusion, increased exocytosis activity, and autophagosome-like vesicles inL. infantumpromastigotes treated withM. citrifoliafruit juice.M. citrifoliafruit juice was active againstL. infantumin thein vitromodel used here causing ultrastructural changes and has a future potential for treatment against leishmaniasis.


2007 ◽  
Vol 6 (12) ◽  
pp. 1494-1501 ◽  
Author(s):  
Chang-hong LIU ◽  
Ya-rong XUE ◽  
Yong-hang YE ◽  
Feng-feng YUAN ◽  
Jun-yan LIU ◽  
...  

2010 ◽  
Vol 64 (4) ◽  
pp. 468-473 ◽  
Author(s):  
Shinichi Harada ◽  
Wakako Fujita-Hamabe ◽  
Kohei Kamiya ◽  
Yoshiyuki Mizushina ◽  
Toshiko Satake ◽  
...  

Author(s):  
Nitin D. Jadhav Debi P. Mishra ◽  
Abhinna K. Behera Sudhir R. Rajurkar ◽  
Bhagirath V. Ballurkar

Sign in / Sign up

Export Citation Format

Share Document