scholarly journals Grape Seed Extract (<i>Vitisvinifera</i>) Alleviate Neurotoxicity and Hepatotoxicity Induced by Lead Acetate in Male Albino Rats

2012 ◽  
Vol 02 (02) ◽  
pp. 176-184 ◽  
Author(s):  
Abeer M. Waggas
Keyword(s):  
Lead Acetate ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Albino Rats

scholarly journals Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Heba M. Abdou ◽  
Mayssaa M. Wahby
Keyword(s):  
Vitamin B6 ◽  
Hematological Parameters ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Cerebral Injury ◽  
Pcr Analysis ◽  
Albino Rats ◽  
Inos Mrna ◽  
Protective Effects

Triton WR-1339 administration causes neurotoxicity. Natural products and herbal extracts can attenuate cerebral injury. In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity. Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140–145 g, were divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + triton. The hematological and biochemical analyses were carried out. Alteration in iNOS mRNA gene expression was determined using reverse-transcriptase PCR analysis. In addition, qualitative DNA fragmentation was examined using agarose gel electrophoresis. Triton-treatment caused significant disturbances in the hematological parameters, the neurological functions, and the antioxidant profile. Also, triton significantly increased the iNOS mRNA expression and DNA damage. Our results showed that grape seed extract and/or vitamin B6 could attenuate all the examined parameters. These natural substances could exhibit protective effects against triton-induced neurological damage because of their antioxidative and antiapoptotic capacities.

scholarly journals The Effects of Grape Seed Extract on Insulin, Adiponectin and Resistin Levels in Diabetic Rats

2021 ◽  
Vol 9 (4) ◽  
pp. 709-713
Author(s):  
İnci Söğütlü ◽  
Nihat Mert ◽  
Handan Mert ◽  
Leyla Mis ◽  
Halil Cumhur Yılmaz ◽  
...  
Keyword(s):  
Insulin Level ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Control Group ◽  
Albino Rats ◽  
Diabetes Group ◽  
Positive Effects ◽  
Wistar Albino Rats

In this study, the effects of grape seed extract on insulin, adiponectin and resistin levels in diabetic rats were aimed to investigate. Weight of about 300-350g 7-8 weeks 32 female Wistar Albino rats were used. Weight of about 300-350g 7-8 weeks 32 female Wistar Albino rats randomly divided into four groups of eight each: control group (C), group with diabetes (DM), grape seed extract group (GSE), diabetes mellitus and grape seed extract group (DM+GSE). The diabetic group 45 mg/kg single dose of streptozotocin was administered intraperitoneally, and the grape seed extract groups (DM+GSE and GSE) grape seed extract was given orally every day with an intragastric tube for 20 days (0.6 ml/rat). Blood samples were taken from the hearts of rat’s end of the experiment. The sera obtained were used for insulin, adiponectin and resistin analysis measured via ELISA with commercial kits. The insulin and adiponectin levels of the rats in the diabetes + grape seed extract group were found to be higher than those in the diabetes group. There was no significant change in the resistin level differences between the groups. As a result; It is possible to say that grape seed extract has an increasing effect on insulin level and adiponectin levels of diabetic rats are decreased due to diabetes and it has no significant effect on resistin levels. Detected by the positive effects of grape seed extracts, it may be useful to use for the regulating of the diabetes in human.

scholarly journals Neuroprotective effect of grape seed extract against cadmium toxicity in male albino rats

2016 ◽  
Vol 29 (3) ◽  
pp. 398-407 ◽  
Author(s):  
Adel El-Sayed El-Tarras ◽  
Hossam Fouad Attia ◽  
Mohammed Mohamed Soliman ◽  
Mohammed Abdelhamid El Awady ◽  
Adnan Abelghani Amin
Keyword(s):  
Neuroprotective Effect ◽  
Cadmium Toxicity ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Albino Rats

scholarly journals Potentiation of antifibrotic activity of Atacand using grape seed extract (Gervital) in male albino rats

2015 ◽  
Vol 1 (1) ◽  
pp. 1-9
Author(s):  
Faten Abdel- Ghaffar ◽  
Ibrahim El-Elaimy ◽  
Mona EL. Ghreeb ◽  
Azza Mohamed
Keyword(s):  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Albino Rats

Grape Seeds Extract as Brain Food: A Review

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Souad El Gengaihi ◽  
Doha H. Abou Baker
Keyword(s):  
Antioxidant Activities ◽  
Complex Mixture ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Amyloid Peptide ◽  
Grape Seeds ◽  
Potential Benefits ◽  
Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

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