scholarly journals Influence of Iron Deficiency on Olfactory Behavior in Weanling Rats

2012 ◽  
Vol 02 (02) ◽  
pp. 167-175 ◽  
Author(s):  
V. M. Ruvin Kumara ◽  
Marianne Wessling-Resnick
Keyword(s):  
Iron Deficiency ◽  
Olfactory Behavior ◽  
Weanling Rats

Muscle mitochondrial ultrastructure in exercise-trained iron-deficient rats

1990 ◽  
Vol 68 (1) ◽  
pp. 113-118 ◽  
Author(s):  
J. A. Johnson ◽  
W. T. Willis ◽  
P. R. Dallman ◽  
G. A. Brooks
Keyword(s):  
Iron Deficiency ◽  
Lipid Droplets ◽  
Ultrastructural Changes ◽  
Mitochondrial Enzymes ◽  
Mitochondrial Ultrastructure ◽  
Combined Stresses ◽  
Transport Chain ◽  
Iron Deficient ◽  
Weanling Rats ◽  
And Training

To investigate effects of endurance training and iron deficiency, as well as the combination of these two conditions, on mitochondrial ultrastructure, weanling rats at 3 wk of age were assigned to iron-deficient (Fe-) and iron-sufficient (Fe+) groups. Subsequently, groups were subdivided into exercise-trained (T) and sedentary (S) groups. Electron microscopy showed subsarcolemmal and intrafibrillar mitochondria in the Fe-T animals to be enlarged with sparse cristae and vacuole-like areas compared with the other groups. An increase in the number of lipid droplets in both Fe- groups was observed. Stereological measurements revealed a 99% increase in the volume occupied by muscle mitochondria in the Fe-T animals (11.9 +/- 0.8%) over the Fe+T (5.9 +/- 0.4%) and Fe+S (6.0 +/- 0.3%) groups and a 55% increase over the Fe-S groups (7.7 +/- 0.3%). The ratio of mitochondrial surface area to tissue volume was significantly decreased only in the Fe-T group. These results indicate that the combined stresses of iron deficiency and training produce mitochondrial ultrastructural changes far greater than those of iron deficiency or training alone. Because this is also the case with the disproportion among mitochondrial enzymes, it is possible that the ultrastructural changes are indicative of morphological responses that maintain ATP turnover during exercise in iron deficiency when oxygen transport and electron transport chain activities are reduced.

Distinguishing effects of anemia and muscle iron deficiency on exercise bioenergetics in the rat

1984 ◽  
Vol 246 (6) ◽  
pp. E535-E543 ◽  
Author(s):  
K. J. Davies ◽  
C. M. Donovan ◽  
C. J. Refino ◽  
G. A. Brooks ◽  
L. Packer ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Work Load ◽  
Time To Exhaustion ◽  
Endurance Capacity ◽  
Dietary Iron ◽  
Iron Deficient ◽  
Weanling Rats ◽  
O2 Delivery ◽  
And Control ◽  
Intermediate Concentration

Three weeks of dietary iron deficiency in weanling rats resulted in anemia (Hb, 3.9 vs. 14.2 g/dl in controls) and decreased oxidative capacities of skeletal muscle (as much as 90% below control values). Whole-animal maximal O2 consumption (VO2max), measured in a brief treadmill run of progressively increasing work load, was approximately 50% lower for iron-deficient rats than for controls, and maximal endurance capacity (time to exhaustion in a separate treadmill run at a constant, sub-Vo2max work load) was 90% lower for iron-deficient rats than for controls. Exchange transfusion, with packed erythrocytes or plasma, was used to adjust Hb to an intermediate concentration of approximately 9.5 g/dl in both iron-deficient and and control rats. This procedure corrected the Vo2max of iron-deficient rats to within 15% of control values, whereas endurance capacity showed no improvement. Our experimental dissociation of Vo2max and endurance capacity provides further evidence that Vo2max is not the sole determinant of endurance. We propose that defects in Vo2max during iron deficiency result primarily from diminished O2 delivery, whereas decreased endurance capacity reflects impaired muscle mitochondrial function.

Is iron deficiency investigated appropriately?

2001 ◽  
Vol 120 (5) ◽  
pp. A728-A729
Author(s):  
A DIMAMBRO ◽  
T BROOKLYN ◽  
N HASLAM
Keyword(s):  
Iron Deficiency
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