scholarly journals Comparative Evaluation of Ozone Treatment in Critical Size Bone Defects Reconstructed with Alloplastic Bone Grafts

2018 ◽  
Vol 09 (07) ◽  
pp. 566-579 ◽  
Author(s):  
Nihat Laçin ◽  
Beyza Kaya ◽  
Engin Deveci ◽  
Ela Tules Kadiroğlu ◽  
Ayfer Aktaş ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Critical Size ◽  
Bone Grafts ◽  
Bone Defects ◽  
Ozone Treatment

Engineering Human-Scale Artificial Bone Grafts for Treating Critical-Size Bone Defects

2019 ◽  
Vol 2 (11) ◽  
pp. 5077-5092 ◽  
Author(s):  
Alessandro Cianciosi ◽  
Marco Costantini ◽  
Sara Bergamasco ◽  
Stefano Testa ◽  
Ersilia Fornetti ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Grafts ◽  
Bone Defects ◽  
Artificial Bone ◽  
Human Scale

scholarly journals Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study

2021 ◽  
Vol 11 (1) ◽  
pp. 395
Author(s):  
Antonio Scarano ◽  
Francesco Inchingolo ◽  
Biagio Rapone ◽  
Alberta Greco Lucchina ◽  
Erda Qorri ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
New Bone Formation ◽  
Platelet Gel ◽  
Woven Bone ◽  
Rapid Healing ◽  
Rabbit Bone ◽  
Autologous Platelet ◽  
New Zealand Rabbits

Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.

scholarly journals Additive Manufacturing of β-Tricalcium Phosphate Components via Fused Deposition of Ceramics (FDC)

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 156
Author(s):  
Steffen Esslinger ◽  
Axel Grebhardt ◽  
Jonas Jaeger ◽  
Frank Kern ◽  
Andreas Killinger ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Critical Size ◽  
Bone Defects ◽  
Healthcare Systems ◽  
The Body ◽  
Patient Specific ◽  
Poly Lactic Acid ◽  
Fused Deposition ◽  
Poly Ethylene ◽  
Fused Deposition Of Ceramics

Bone defects introduced by accidents or diseases are very painful for the patient and their treatment leads to high expenses for the healthcare systems. When a bone defect reaches a critical size, the body is not able to restore this defect by itself. In this case a bone graft is required, either an autologous one taken from the patient or an artificial one made of a bioceramic material such as calcium phosphate. In this study β-tricalcium phosphate (β-TCP) was dispersed in a polymer matrix containing poly(lactic acid) (PLA) and poly(ethylene glycole) (PEG). These compounds were extruded to filaments, which were used for 3D printing of cylindrical scaffolds via Fused Deposition of Ceramics (FDC) technique. After shaping, the printed parts were debindered and sintered. The components combined macro- and micropores with a pore size of 1 mm and 0.01 mm, respectively, which are considered beneficial for bone healing. The compressive strength of sintered cylindrical scaffolds exceeded 72 MPa at an open porosity of 35%. The FDC approach seems promising for manufacturing patient specific bioceramic bone grafts.

scholarly journals Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Annika Kengelbach-Weigand ◽  
Carolina Thielen ◽  
Tobias Bäuerle ◽  
Rebekka Götzl ◽  
Thomas Gerber ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Large Scale ◽  
Critical Size ◽  
Therapeutic Option ◽  
Living Organism ◽  
Bone Defects ◽  
Sheep Model ◽  
Simple Alternative ◽  
Translational Approach ◽  
Near Future

AbstractTissue engineering principles allow the generation of functional tissues for biomedical applications. Reconstruction of large-scale bone defects with tissue-engineered bone has still not entered the clinical routine. In the present study, a bone substitute in combination with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) with or without growth factors BMP-2 and VEGF-A was prevascularized by an arteriovenous (AV) loop and transplanted into a critical-size tibia defect in the sheep model. With 3D imaging and immunohistochemistry, we could show that this approach is a feasible and simple alternative to the current clinical therapeutic option. This study serves as proof of concept for using large-scale transplantable, vascularized, and customizable bone, generated in a living organism for the reconstruction of load-bearing bone defects, individually tailored to the patient’s needs. With this approach in personalized medicine for the reconstruction of critical-size bone defects, regeneration of parts of the human body will become possible in the near future.

scholarly journals Regenerating Critical Size Rat Segmental Bone Defects with a Self‐Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP‐2 Incorporation

2021 ◽  
pp. 2100088
Author(s):  
Claire I. A. Houdt ◽  
Marianne K. E. Koolen ◽  
Paula M. Lopez‐Perez ◽  
Dietmar J. O. Ulrich ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
Self Healing ◽  
Nanocomposite Hydrogel ◽  
Hybrid Nanocomposite ◽  
Segmental Bone ◽  
Bone Condition ◽  
Segmental Bone Defects

scholarly journals Augmentation of Peri-implant Bone Defects with Different Bone Grafts and Guided Bone Regeneration:

2006 ◽  
Vol 15 (3) ◽  
pp. 82-88 ◽  
Author(s):  
Weijian Zhong ◽  
Guowu Ma ◽  
Yi Wang ◽  
Ryo Tamamura ◽  
Jing Xiao
Keyword(s):  
Bone Regeneration ◽  
Bone Grafts ◽  
Bone Defects ◽  
Guided Bone Regeneration

scholarly journals Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats

2020 ◽  
Vol 9 (9) ◽  
pp. e530997474
Author(s):  
Alexadre Aniceto Rodrigues ◽  
Thiago Donizeth da Silva ◽  
Evelise Aline Soares ◽  
José Antônio Dias Garcia ◽  
Flavia da Ré Guerra ◽  
...  
Keyword(s):  
Mechanical Testing ◽  
Structural Properties ◽  
Wistar Rats ◽  
Biomechanical Properties ◽  
Bone Defects ◽  
Biomechanical Analysis ◽  
Maximum Force ◽  
Ozone Treatment ◽  
Control Group ◽  
Tissue Healing

Introduction: Ozone is a potent antioxidant that acts as a precursor of various radicals, being indicated as a powerful therapy, assisting in the process of tissue healing. Objectives: The proposal of this study was to analyze material and structural properties via mechanical testing in tibias after application of ozone in bone defects produced surgically. Methods: Ten male 40-day old albino Wistar rats have been used, divided in two groups: control group and ozone group, this last one being treated with ozonized water in 25 µg/mL of concentration until the day of euthanasia. Trichotomy and longitudinal incision was conducted in the animals’ leg skin, exposing the tibia’s diaphysis of both antimers, and with help of a high rotation pen a flaw has been produced on the bone. After 60 days of surgery the animals were euthanized, and tibias were collected for biomechanical analysis. Results: The results of the biomechanical properties – structural and material – evidenced significant interactions through exposure to ozone, showing a diminished bone resistance in animals from the control group, observed by the decrease of the maximum force (N) needed to rupture the bone when compared to the value needed to break the bones of the animals from the ozone group, and the analysis of the morphometrical properties did not show any difference between both experimental groups. Conclusion: The use of ozone did not alter the morphological structures of the tibias, and the group which used ozone presented more resistance during mechanical testings, because the maximum force for the rupture of tibia was greater in this group.

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