scholarly journals Evaluation of the Effect of <i>Gurusa</i>, a Ugandan Cereal-Based Fermented Food on Serum Lipid Profile and Body Weight of Wistar Albino Rats

2016 ◽  
Vol 07 (04) ◽  
pp. 284-293
Author(s):  
Atamgba Agbor Asuk ◽  
Abbas Kisambira ◽  
Muhammad Lubowa ◽  
Denis Ssenabulya
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Fermented Food ◽  
Serum Lipid Profile ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Efficacy of Zanthoxylum armatum fruit on isoproterenol induced myocardial infarction in rats

2019 ◽  
Vol 8 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Malathi Mangalanathan ◽  
Tamiloli Devendhiran ◽  
Saraswathi Uthamaramasamy ◽  
Keerthika Kumarasamy ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Lipid Profile ◽  
Troponin T ◽  
Serum Markers ◽  
Albino Rats ◽  
Zanthoxylum Armatum ◽  
Creatine Kinase Mb ◽  
Enzymic Antioxidants ◽  
Wistar Albino Rats

The present study was elucidating the cardioprotective activity of hydroethanoic extract of Zanthoxylum armatum (Z. armatum) fruit on serum cardiac markers, lipid profile and the level of antioxidants in experimentally induced myocardial infarction (MI). The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400 mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, isoproterenol (ISO) (8.5mg/100g body weight) wasadministered to induce MI. Animals were sacrificed; blood and heart tissues were removed and the biochemical parameters were carried out. Serum markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and troponin –T were significantly (p<0.05) increased after ISO treatment. Altered lipid profile and significant changes in enzymic and non- enzymic antioxidants were also observed in MI. The altered levels were brought back to near normal by the administration of hydroethanoic extract of Z. armatum fruit which might be due to the active phytoconstituents present in it.

scholarly journals Effect of Stellaria media Tea on Lipid Profile in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Virág Demján ◽  
Tivadar Kiss ◽  
Andrea Siska ◽  
Márton Richárd Szabó ◽  
Márta Sárközy ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Stellaria Media ◽  
Experimental Proof ◽  
Cardiac Morphology ◽  
Liver And Kidney ◽  
And Function

Background. In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media tea in hypercholesterolemic rats. Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media tea lyophilizate for 8 weeks. Blood samples were collected to determine serum lipid profile as well as liver and kidney function, and echocardiography was performed to assess cardiac morphology and function. Results. Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media tea lyophilizate. Conclusion. Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia.

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