scholarly journals A Diet with 3% of Energy from a Mixture of Omega-3 Fatty Acids Significantly Increases <i>in Vivo</i> Lipid Peroxidation in Postmenopausal Women

2016 ◽  
Vol 07 (12) ◽  
pp. 1099-1111
Author(s):  
A. Saari Csallany ◽  
Cheryl E. Ainslie-Waldman ◽  
Lindsay R. Young ◽  
Chi Chen ◽  
Mindy S. Kurzer ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Postmenopausal Women ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Lipid Peroxidation and Omega-3 Fatty Acids

1996 ◽  
pp. 681-687
Author(s):  
Christian A. Drevon ◽  
Ingeborg R. Brude ◽  
Marit S. Nenseter
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Ultralong TE In Vivo 1 H MR Spectroscopy of Omega‐3 Fatty Acids in Subcutaneous Adipose Tissue at 7 T

2018 ◽  
Vol 50 (1) ◽  
pp. 71-82 ◽  
Author(s):  
Martin Gajdošík ◽  
Lukas Hingerl ◽  
Antonín Škoch ◽  
Angelika Freudenthaler ◽  
Patrik Krumpolec ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Mr Spectroscopy ◽  
Subcutaneous Adipose Tissue ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Subcutaneous Adipose

scholarly journals Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Belmiro Parada ◽  
Flávio Reis ◽  
Raquel Cerejo ◽  
Patrícia Garrido ◽  
José Sereno ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bladder Cancer ◽  
Rat Model ◽  
Redox Status ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Markers Of Inflammation ◽  
Male Wistar Rats ◽  
Serum Crp

Omega-3 (ω-3) fatty acids have been tested on prevention and treatment of several cancer types, but the efficacy on “in vivo” bladder cancer has not been analyzed yet. This study aimed at evaluating the chemopreventive efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) mixture in an animal model of bladder cancer. Forty-four male Wistar rats were divided into 4 groups during a 20-week protocol: control; carcinogen—N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN);ω-3 (DHA + EPA); andω-3 + BBN. BBN andω-3 were given during the initial 8 weeks. At week 20 blood and bladder were collected and checked for the presence of urothelium lesions and tumors, markers of inflammation, proliferation, and redox status. Incidence of bladder carcinoma was, control (0%),ω-3 (0%), BBN (65%), andω-3 + BBN (62.5%). Theω-3 + BBN group had no infiltrative tumors or carcinomain situ, and tumor volume was significantly reduced compared to the BBN (0.9 ± 0.1 mm3versus 112.5 ± 6.4 mm3). Also, it showed a reduced MDA/TAS ratio and BBN-induced serum CRP, TGF-β1, and CD31 were prevented. In conclusion, omega-3 fatty acids inhibit the development of premalignant and malignant lesions in a rat model of bladder cancer, which might be due to anti-inflammatory, antioxidant, anti-proliferative, and anti-angiogenic properties.

scholarly journals Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
S. C. Sargi ◽  
M. M. O. Dalalio ◽  
A. G. Moraes ◽  
J. E. L. Visentainer ◽  
D. R. Morais ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Peritoneal Macrophages ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Potential Health ◽  
Macrophage Activity ◽  
Experimental Paracoccidioidomycosis

There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE2and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE2in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challengedin vitrowith Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE2in vivoin the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis.

Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARα

Blood ◽  
2002 ◽  
Vol 100 (4) ◽  
pp. 1340-1346 ◽  
Author(s):  
Sanjeev Sethi ◽  
Ouliana Ziouzenkova ◽  
Heyu Ni ◽  
Denisa D. Wagner ◽  
Jorge Plutzky ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Inflammatory Diseases ◽  
Receptor Expression ◽  
Peroxisome Proliferator ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Peroxisome Proliferator Activated Receptor

Omega-3 fatty acids, which are abundant in fish oil, improve the prognosis of several chronic inflammatory diseases although the mechanism for such effects remains unclear. These fatty acids, such as eicosapentaenoic acid (EPA), are highly polyunsaturated and readily undergo oxidation. We show that oxidized, but not native unoxidized, EPA significantly inhibited human neutrophil and monocyte adhesion to endothelial cells in vitro by inhibiting endothelial adhesion receptor expression. In transcriptional coactivation assays, oxidized EPA potently activated the peroxisome proliferator-activated receptor α (PPARα), a member of the nuclear receptor family. In vivo, oxidized, but not native, EPA markedly reduced leukocyte rolling and adhesion to venular endothelium of lipopolysaccharide (LPS)–treated mice. This occurred via a PPARα-dependent mechanism because oxidized EPA had no such effect in LPS-treated PPARα-deficient mice. Therefore, the beneficial effects of omega-3 fatty acids may be explained by a PPARα-mediated anti-inflammatory effect of oxidized EPA.

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