scholarly journals Immunomodulatory Activities of a Concentrated Fruit and Vegetable Juice Tested in a Randomized, Placebo-Controlled, Double-Blind Clinical Trial in Healthy Volunteers

2014 ◽  
Vol 05 (04) ◽  
pp. 341-350 ◽  
Author(s):  
Manfred Schmolz ◽  
Reinhard W. März ◽  
Marco Schaudt ◽  
Cornelia Schaudt ◽  
Carola Lauster
Keyword(s):  
Clinical Trial ◽  
Healthy Volunteers ◽  
Fruit And Vegetable ◽  
Double Blind ◽  
Vegetable Juice ◽  
Double Blind Clinical Trial ◽  
Fruit And Vegetable Juice

scholarly journals Intestinal Bacteroides Levels are Reduced by a Fruit and Vegetable Juice Concentrate

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1596-1596
Author(s):  
Marie van der Merwe ◽  
Damien Moore ◽  
Jessica Hill ◽  
Faith Keating ◽  
Richard Bloomer ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Sequencing Analysis ◽  
Fruit And Vegetable ◽  
Double Blind ◽  
Female Population ◽  
Vegetable Juice ◽  
Inflammatory Status ◽  
Obese Female ◽  
Juice Concentrate ◽  
Fruit And Vegetable Juice

Abstract Objectives Phytochemicals from fruits and vegetables have the potential to reduce inflammation and improve overall health. This study evaluated the effect of an encapsulated fruit and vegetable juice concentrate (FVC) on the composition and abundances of intestinal microbiota in an overweight/obese, female population and the association with indicators of metabolic health and inflammatory status. Methods The study was performed as a randomized, double blind, placebo-controlled trial with 57 asymptomatic, pre-menopausal, overweight/obese (BMI between 25 and 40 kg/m2) females between 25–50 years of age and working in the healthcare field. Blood and fecal samples were collected before and after eight and sixteen weeks of daily supplementation with FVC. Metabolic and immune parameters were measured, and the gut microbiome was analyzed by sequencing of the V4 region of the 16SrRNA gene. Results The FVC supplementation did not change serum cholesterol, HDL, LDL, triglycerides and fasting glucose, or fasting cytokine levels for MCP1, MIP-1β, TNF-α, IL-10, IL-1β, IL-6, and Leptin. Sequencing analysis revealed the most abundant phyla detected at baseline in this population were Firmicutes (75.75 ± 10.59%), Bacteroidetes (15.23 ± 12.5%), with Actinobacteria, Proteobacteria and Verrucomicrobia also present. The following genera was most abundant in the study population: Blautia (22 ± 12.86%), Roseburia (8.03 ± 7.34%), Coprococus (5.44 ± 4.0%), Faecalibatcerium (11.12 ± 8.12%) and Bacteroides (10.89 ± 9.56%). FCV supplementation did not result in significant taxonomic changes at the level of phyla, or alter alpha (Shannon Index) or beta diversity (Bray Curtis analysis). However, there was a consistent reduction in overall bacterial abundance in the FVC supplemented group. This reduction was primarily attributed to the decrease in the gram-negative, anaerobic genus, Bacteroides (P = 0.08). Conclusions An encapsulated fruit and vegetable juice concentrate did not alter metabolic or inflammatory indicators in a healthy, overweight/obese female population, but resulted in a reduced abundance of the intestinal bacterial population, Bacteroides. Funding Sources NSA LLC/The Juice Plus+® Company.

Safety of a universal, virus-inactivated and prion-depleted, pharmaceutical-quality plasma: a randomized, double-blind, clinical trial in healthy volunteers

Transfusion ◽  
2011 ◽  
Vol 51 (6) ◽  
pp. 1228-1240 ◽  
Author(s):  
Petra Jilma-Stohlawetz ◽  
Friedrich W. Kursten ◽  
Claudia Walasek ◽  
Michaela Horvath ◽  
Gerda Leitner ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Healthy Volunteers ◽  
Double Blind ◽  
Pharmaceutical Quality ◽  
Double Blind Clinical Trial

Effects of heat-treated Lactobacillus crispatus KT-11 strain consumption on improvement of oral cavity environment: a randomised double-blind clinical trial

2018 ◽  
Vol 9 (4) ◽  
pp. 585-592 ◽  
Author(s):  
K. Tobita ◽  
I. Watanabe ◽  
M. Tomokiyo ◽  
M. Saito
Keyword(s):  
Clinical Trial ◽  
Lactic Acid ◽  
Placebo Group ◽  
Lactic Acid Bacteria ◽  
Periodontal Disease ◽  
Healthy Volunteers ◽  
Double Blind ◽  
Lactobacillus Crispatus ◽  
Heat Treated ◽  
Double Blind Clinical Trial

Heat-treated lactic acid bacteria is added to some foods because it is easier to store and transport, and have less interference with other food ingredient compared with living lactic acid bacteria. We have reported that oral administration of heat-treated Lactobacillus crispatus KT-11 strain (KT-11) suppressed the symptoms of periodontal disease in mice orally infected with Porphyromonas gingivalis. However, the preventive effect of KT-11 on periodontal disease in human is unclear. The aim of this randomised double-blind clinical trial was to examine the effects of KT-11 consumption on the oral environment in healthy volunteers. Sixteen healthy volunteers were randomly assigned to two groups (KT-11 or placebo), and they consumed a KT-11 food tablet (1.2×1010 KT-11 cells) or a placebo food tablet (without KT-11) every day for 4 weeks. Clinical parameters including numbers of major periodontopathic bacteria in saliva, plaque score, gum conditions, and oral mucosal fluid level were evaluated at weeks 0 and 4. Amount of change in P. gingivalis numbers decreased in the KT-11 group compared to that in the placebo group at week 4. Female participants in the KT-11 group had decreased plaque scores, reddish tinge, and gingival swelling scores compared to those in the placebo group at week 4. Furthermore, male participants in the KT-11 group demonstrated increased oral mucosa fluid scores. These clinical findings suggest that daily KT-11 intake can prevent periodontal disease through the improvement of oral conditions.

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