scholarly journals Neuroprotective Effects of Ginkgo Biloba Extract (GbE) on Oxygen-Glucose Deprivation (OGD) in PC12 Cells

Engineering ◽  
2013 ◽  
Vol 05 (10) ◽  
pp. 142-145
Author(s):  
Chunli Mei ◽  
Xuelu Han ◽  
Jing Zhang ◽  
Ling Gao ◽  
Huimin Liu
Keyword(s):  
Pc12 Cells ◽  
Ginkgo Biloba ◽  
Glucose Deprivation ◽  
Ginkgo Biloba Extract ◽  
Oxygen Glucose Deprivation ◽  
Neuroprotective Effects

scholarly journals Neuroprotective effects of leonurine against oxygen–glucose deprivation by targeting Cx36/CaMKII in PC12 cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200705 ◽  
Author(s):  
Jiao Li ◽  
Shuang Zhang ◽  
Xiaoxi Liu ◽  
Deping Han ◽  
Jianqin Xu ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Neuroprotective Effects

scholarly journals Neuroprotective effects of microRNA-210 against oxygen-glucose deprivation through inhibition of apoptosis in PC12 cells

2013 ◽  
Vol 7 (6) ◽  
pp. 1955-1959 ◽  
Author(s):  
JIE QIU ◽  
XIAO-YU ZHOU ◽  
XIAO-GUANG ZHOU ◽  
RUI CHENG ◽  
HAI-YING LIU ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Neuroprotective Effects

scholarly journals rLj-RGD3, a Novel Three-RGD-Motif-Containing Recombinant Protein fromLampetra japonica, Protects PC12 Cells from Injury Induced by Oxygen-Glucose Deprivation and Reperfusion

2016 ◽  
Vol 2016 ◽  
pp. 1-9
Author(s):  
Li Lv ◽  
Qian Lu ◽  
Fangyu Shao ◽  
Weiping Li ◽  
Qin Zhou ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Protein Expression ◽  
Pc12 Cells ◽  
Caspase 3 ◽  
Ischemia Reperfusion ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
High Dose ◽  
Neuroprotective Effects ◽  
Tumour Metastasis

rLj-RGD3 is a 14.5 kDa recombinant protein with 3 RGD (Arg-Gly-Asp) motifs from the salivary gland secretions ofLampetra japonica, which is a histidine-rich and arginine-rich protein. Previous reports indicated that rLj-RGD3 has typical functions of RGD-toxin protein, such as platelet aggregation suppression tumour metastasis and angiogenesis inhibition. Because histidine and arginine have cerebral ischemia-reperfusion and neuroprotective functions, we investigated whether rLj-RGD3 has such activities and studied the mechanism. The effects of rLj-RGD3 on neuroprotection and antiapoptosis were determined. The expression level of focal adhesion kinase (FAK), p-FAK, Caspase-3, and Bcl-2 after oxygen-glucose deprivation and reperfusion (OGD-R) was examined. The viability of PC12 cells incubated with rLj-RGD3 at high concentrations (16 μmol/L) increased significantly due to its ability to protect the cells from apoptosis after OGD-R-induced injury. Furthermore, rLj-RGD3 attenuated the damage due to OGD-R. Most of the PC12 cells were apoptotic after OGD-R. In contrast, the number of apoptotic PC12 cells was significantly decreased in the group treated with a high-dose of rLj-RGD3. In addition, rLj-RGD3 activated FAK and p-FAK protein. rLj-RGD3 inhibited Caspase-3 and upregulated Bcl-2 protein expression in PC12 cells after OGD-R. The study provides the first evidence for neuroprotective effects of rLj-RGD3 in ischemic injury that may be partly mediated through inhibition of Caspase-3 and upregulation of Bcl-2, FAK, and p-FAK protein expression.

scholarly journals Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells

Molecules ◽  
2011 ◽  
Vol 17 (1) ◽  
pp. 315-327 ◽  
Author(s):  
Jin-Ting He ◽  
Jing Mang ◽  
Chun-Li Mei ◽  
Le Yang ◽  
Jiao-Qi Wang ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Glucose Deprivation ◽  
Activin A ◽  
Oxygen Glucose Deprivation ◽  
Neuroprotective Effects
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