scholarly journals Tremendous Improvement of the Functional Capacity in Patient with Chronic Heart Failure after 12-Weeks of Exercise Training Program

2020 ◽  
Vol 09 (08) ◽  
pp. 236-241
Author(s):  
Adam Staron ◽  
Jadwiga Wolszakiewicz ◽  
Mohammed Al Otaiby ◽  
Justyna Irla-Czyzycka ◽  
Ibrahim Al Malki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Exercise Training ◽  
Training Program ◽  
Functional Capacity ◽  
Exercise Training Program

P753Exercise has similar beneficial effect in the mobilization of endothelial progenitor cells in patients with chronic heart failure of different severity

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Kourek ◽  
E Karatzanos ◽  
K Psarra ◽  
G Mitsiou ◽  
D Delis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Exercise Training ◽  
Training Program ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Peak Vo2 ◽  
Exercise Training Program ◽  
Before And After

Abstract Introduction Vascular endothelial dysfunction is an underlying pathophysiological feature of chronic heart failure (CHF). Exercise has been shown to stimulate the mobilization of endothelial progenitor cells (EPC) in healthy populations. EPC contribute to the regeneration of the inflammatory endothelium and promote neovascularization. Purpose The purpose of the present study was to investigate the mobilization of EPC between CHF patients with different severity after a 36-session exercise training program. Methods Thirty eight consecutive patients (32 ♂, 6 ♀) with stable CHF [mean±SD, age (years): 56±10, EF (%): 32±9, peak VO2 (ml/kg/min): 18.1±4.1] enrolled a 36-session exercise training program. All patients underwent a symptom limited maximal cardiopulmonary exercise testing (CPET) on a cycle ergometer before and after the training program. Venous blood was sampled before and after each CPET. Five endothelial circulating populations were quantified by flow cytometry (Table 1). Patients were divided in severity groups according to the median values of peak VO2, predicted peak VO2, VE/VCO2 slope and EF. EPC values are expressed as “cells/million enucleated cells” in medians (25th, 75th percentiles). Results In all patients, rehabilitation showed a statistical significant effect as well as a significant acute effect in all endothelial circulating populations (p<0.001). Although there was statistical significant mobilization of endothelial circulating populations within each severity group (groups separated by peak VO2), no differences were observed between groups (p>0.05, Table 1). Similar results were also shown for the rest of CPET parameters and EF. Cellular populations in severity groups Endothelial cellular populations Peak VO2 <18 ml/kg/min Peak VO2 ≥18 ml/kg/min Before rehabilitation After rehabilitation Before rehabilitation After rehabilitation Before CPET After CPET Before CPET After CPET Before CPET After CPET Before CPET After CPET CD34+/CD45–/CD133+ 54 (24–74) 90 (40–104)* 96 (54–120) 154 (100–169)* 37 (16–66) 60 (33–93)* 79 (46–106) 122 (96–159)* CD34+/CD45–/CD133+/VEGFR2 1 (1–3) 3 (2–8)* 8 (4–9) 14 (10–19)* 2 (1–3) 4 (3–8)* 5 (4–7) 13 (9–16)* CD34+/CD133+/VEGFR2 13 (8–18) 13 (9–25) 22 (16–31) 27 (14–38) 10 (7–19) 14 (9–20)** 16 (13–37) 22 (15–62)** CD34+/CD45–/CD133– 186 (131–368) 494 (202–640)* 431 (301–564) 738 (590–921)* 214 (150–270) 306 (233–575)* 434 (277–835) 740 (524–1588)* CD34+/CD45–/CD133–/VEGFR2 2 (1–2) 3 (2–5)* 4 (3–5) 10 (9–14)* 1 (1–1) 3 (2–5)* 4 (2–8) 9 (7–12)* Differences within groups *p<0.001, **p<0.05. Conclusion A 36-session training program stimulates the long term mobilization of EPC in CHF patients. This mobilization seems to be similar in all patients irrespective of their severity. The clinical relevance of these findings and the potential mechanisms need further investigation. Acknowledgement/Funding Greece and the European Union (European Social Fund-ESF) through the Operational Programme “Human Resources Development, Education, Lifelong Learning”

A Longitudinal Study of Quality of Life in Patients with Chronic Heart Failure Following an Exercise Training Program

2009 ◽  
Vol 8 (4) ◽  
pp. 281-287 ◽  
Author(s):  
Eckart Miche ◽  
Elisabeth Roelleke ◽  
Bettina Zoller ◽  
Ulrike Wirtz ◽  
Melanie Schneider ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Longitudinal Study ◽  
Chronic Heart Failure ◽  
Exercise Training ◽  
Training Program ◽  
Exercise Training Program

Impact of an exercise training program on cardiac neuronal function in heart failure patients on optimal medical therapy

2017 ◽  
Vol 25 (4) ◽  
pp. 1164-1171
Author(s):  
Torstein Valborgland ◽  
Kjetil Isaksen ◽  
Peter Scott Munk ◽  
Zbigniew Piotr Grabowski ◽  
Alf Inge Larsen
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Training Program ◽  
Medical Therapy ◽  
Optimal Medical Therapy ◽  
Neuronal Function ◽  
Heart Failure Patients ◽  
Exercise Training Program

scholarly journals How to Improve the Functional Capacity of Frail and Pre-Frail Elderly People? Health, Nutritional Status and Exercise Intervention. The EXERNET-Elder 3.0 Project

2020 ◽  
Vol 12 (15) ◽  
pp. 6246 ◽  
Author(s):  
Ángel Iván Fernández-García ◽  
Alba Gómez-Cabello ◽  
Ana Moradell ◽  
David Navarrete-Villanueva ◽  
Jorge Pérez-Gómez ◽  
...  
Keyword(s):  
Exercise Training ◽  
Training Program ◽  
Functional Capacity ◽  
Exercise Intervention ◽  
Intervention Group ◽  
Residual Effects ◽  
Control Group ◽  
Healthy Habits ◽  
Exercise Training Program ◽  
Frail Elderly People

Aging is associated with the impairment of health and functional capacity, and physical exercise seems to be an effective tool in frailty prevention and treatment. The purpose of this study was to present the methodology used in the EXERNET-Elder 3.0 project that aims to evaluate the immediate and residual effects and of a multicomponent exercise training program called Elder-fit on frailty, fitness, body composition and quality of life, and also to analyse a possible dietary intake interaction according to health and metabolic status. A total of 110 frail and pre-frail elders participated in this study and were divided into a control group (CG = 52) and an intervention group (IG = 58). The IG performed a supervised multicomponent exercise training program of 6 months and 3 days per week, which included strength, endurance, balance, coordination and flexibility exercises, while the CG continued with their usual daily activities. Both groups received four speeches about healthy habits along the project. Four evaluations were performed: at baseline, after 3 months of training, at the end of the training program (6 months) and 4 months after the program had ended to examine the effects of detraining. Evaluating the efficacy, safety and feasibility of this program will help to develop efficacious physical interventions against frailty. Further, protocols should be described accurately to allow exercise programs to be successfully replicated.

scholarly journals Increased VO2 peak after a structured exercise-training program is associated with reduced levels of cardiac myosin binding protein C in patients with symptomatic chronic heart failure

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
E.A Riveland ◽  
T Valborgland ◽  
A Ushakova ◽  
T Karlsen ◽  
C Delagardelle ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Training Program ◽  
Plasma Levels ◽  
Intervention Group ◽  
Cardiac Myosin ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Exercise Training Program ◽  
Myosin Binding

Abstract Background Cardiac myosin-binding protein C (cMyC), a cardiac contractile protein, is a novel biomarker of myocardial injury, rising earlier and disappearing faster than cardiac troponins. It is a promising biomarker for use in triage of patients with chest pain presenting in the emergency department. It also has prognostic significance in patients with heart failure. However, the effects of systematic exercise training on plasma levels of cMyC has previously not been evaluated. Purpose The aim of this study was to assess the effect of a 12-week exercise training program on changes in plasma levels of cMyC in patients with chronic symptomatic heart failure with reduced ejection fraction (HFrEF). The changes in plasma levels of cMyC in an intervention group, performing structured exercise programs, were compared to those in a control group, instructed to perform regular recommended exercise (RRE) according to current guidelines. Methods This was a post hoc analysis of the SMARTEX-HF trial in 215 patients with symptomatic HF with Left Ventricular Ejection Fraction (LVEF) &lt;35% and NYHA II-III. The patients were randomly assigned to High Intensity Interval Training (HIIT, n=77), Moderate Continuous Training (MCT, n=65) or RRE, (n=73) for 12 weeks. HIIT and MCT groups constituted the intervention group (IG). Measurements and clinical data were acquired before and after the 12-week intervention. Statistical analysis We divided the patients in two groups with Δ VO2Peak above and below the median of the sample. The absolute changes of cMyC were then compared between the two groups. Mann-Whitney U test was used to compare continuous variables between the groups. Chi-squared test and Fisher exact test were used to compare categorical variables, as appropriate. A two-tailed p&lt;0.05 was considered significant. Results There were no differences in changes of cMyC plasma levels, measured at baseline and after the intervention, between patients in the IG and RRE-group (p=0.580). When dividing the entire study population according to Δ VO2Peak higher or lower than median value 0.48 ml/kg/min, we found a statistically significant greater reduction of cMyC values after 12 weeks of exercise training for those with higher than median Delta VO2Peak values compared to those with lower values (p=0.012). This finding was even stronger for the percentage change in cMyC levels (p=0.004 between groups). Conclusion In patients with symptomatic chronic HFrEF performing a structured 12-week exercise training program, a greater increase in Δ VO2Peak is significantly associated with a reduction in cMyC, suggesting cMyC may provide a dynamic measure of cardiorespiratory state. FUNDunding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): Central Norwegian Health authority,Norwegian University of Science and Technology Baseline characteristics Boxplot cMyC vs peak VO2

scholarly journals PCV92 COST-EFFECTIVENESS OF AN EXERCISE TRAINING PROGRAM IN HEART FAILURE

2009 ◽  
Vol 12 (7) ◽  
pp. A329-A330
Author(s):  
EM Kuhr ◽  
RA Ribeiro ◽  
LE Rohde ◽  
LN Beck da Silva ◽  
NO Clausell ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cost Effectiveness ◽  
Exercise Training ◽  
Training Program ◽  
Exercise Training Program
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