scholarly journals Molecular Docking and Pharmacological Property Analysis of Phytochemicals from <i>Clitoria ternatea</i> as Potent Inhibitors of Cell Cycle Checkpoint Proteins in the Cyclin/CDK Pathway in Cancer Cells

2019 ◽  
Vol 09 (03) ◽  
pp. 81-94 ◽  
Author(s):  
Asad Ullah ◽  
Nazmul Islam Prottoy ◽  
Yusha Araf ◽  
Sohana Hossain ◽  
Bishajit Sarkar ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Molecular Docking ◽  
Cancer Cells ◽  
Pharmacological Property ◽  
Cell Cycle Checkpoint ◽  
Clitoria Ternatea ◽  
Checkpoint Proteins ◽  
Property Analysis ◽  
Cycle Checkpoint

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1997 ◽  
Vol 11 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Peer Bork ◽  
Kay Hofmann ◽  
Philipp Bucher ◽  
Andrew F. Neuwald ◽  
Stephen F. Altschul ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Checkpoint ◽  
Conserved Domains ◽  
Checkpoint Proteins ◽  
Cycle Checkpoint ◽  
Responsive Cell

scholarly journals TMIGD1, a Putative Tumor Suppressor, Induces G2-M Cell Cycle Checkpoint Arrest in Colon Cancer Cells

2020 ◽  
Author(s):  
Kyle De La Cena ◽  
Rachel Xi-Yeen Ho ◽  
Razie Amraei ◽  
Nick Woolf ◽  
Joseph Y. Tashjian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cell Cycle Checkpoint ◽  
Colon Cancer Cells ◽  
M Cell ◽  
Putative Tumor Suppressor ◽  
Cycle Checkpoint

scholarly journals Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Jacquelyn J. Bower ◽  
Leah D. Vance ◽  
Matthew Psioda ◽  
Stephanie L. Smith-Roe ◽  
Dennis A. Simpson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Molecular Subtypes ◽  
Cell Cycle Checkpoint ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cycle Checkpoint

scholarly journals Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach

2020 ◽  
Vol 21 (18) ◽  
pp. 6684
Author(s):  
Samuele Lodovichi ◽  
Tiziana Cervelli ◽  
Achille Pellicioli ◽  
Alvaro Galli
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Repair ◽  
Cancer Therapy ◽  
Clinical Outcome ◽  
Cancer Cells ◽  
Cell Cycle Checkpoint ◽  
Normal Cells ◽  
Cycle Checkpoint ◽  
Repair Pathways

Alterations in DNA repair pathways are one of the main drivers of cancer insurgence. Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they rely on specific functional repair pathways to survive. Thanks to advances in genome sequencing, we now have a better idea of which genes are mutated in specific cancers and this prompted the development of inhibitors targeting DNA repair players involved in pathways essential for cancer cells survival. Currently, the pivotal concept is that combining the inhibition of mechanisms on which cancer cells viability depends is the most promising way to treat tumorigenesis. Numerous inhibitors have been developed and for many of them, efficacy has been demonstrated either alone or in combination with chemo or radiotherapy. In this review, we will analyze the principal pathways involved in cell cycle checkpoint and DNA repair focusing on how their alterations could predispose to cancer, then we will explore the inhibitors developed or in development specifically targeting different proteins involved in each pathway, underscoring the rationale behind their usage and how their combination and/or exploitation as adjuvants to classic therapies could help in patients clinical outcome.

Analysis of key cell-cycle checkpoint proteins in colorectal tumours

2002 ◽  
Vol 196 (4) ◽  
pp. 386-393 ◽  
Author(s):  
Judith A. McKay ◽  
Joy J. Douglas ◽  
Val G. Ross ◽  
Stephanie Curran ◽  
Joseph F. Loane ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Proteins ◽  
Cycle Checkpoint ◽  
Colorectal Tumours
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