scholarly journals Regulation of Hematopoietic Activity Involving New Interacting Partners (RRAGC & PSMC2, CKAP4 & MANF and CTR9 & CNTNAP2)

CellBio ◽  
2020 ◽  
Vol 09 (03) ◽  
pp. 123-141
Author(s):  
Swati Sharma ◽  
Gurudutta U. Gangenahalli ◽  
Upma Singh
Keyword(s):  
Hematopoietic Activity

scholarly journals THE HEMATOPOIETIC ACTIVITY OF XANTHOPTERIN IN YOUNG SALMON

1945 ◽  
Vol 158 (2) ◽  
pp. 449-453
Author(s):  
Earl R. Norris ◽  
Richard W. Simmons
Keyword(s):  
Hematopoietic Activity

Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 863-868 ◽  
Author(s):  
Sophia Khaldoyanidi ◽  
Lyudmila Sikora ◽  
David H. Broide ◽  
Marc E. Rothenberg ◽  
P. Sriramarao
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
Bone Marrow Cells ◽  
Extramedullary Hematopoiesis ◽  
Interleukin 5 ◽  
Bone Marrow Cultures ◽  
Constitutive Overexpression ◽  
Hematopoietic Activity

Abstract The differentiation of eosinophils from hematopoietic precursors and their subsequent maturation, chemotaxis, and activation is primarily regulated by interleukin-5 (IL-5). To examine the effect of chronic IL-5 exposure on hematopoiesis, IL-5 transgenic (IL-5trg) mice and wild-type BALB/c (WT) mice were examined. In comparison to WT mice, a significant alteration in bone marrow hematopoiesis was observed in IL-5trg mice. Although the total number of myeloid progenitors in the bone marrow of IL-5trg mice was not significantly altered, the number of long-term culture-initiating cells (LTC-ICs) was 1.5-fold lower than that observed in WT mice. Furthermore, IL-5trg mice failed to demonstrate hematopoietic activity in long-term bone marrow cultures, which correlated with a significant decrease in the number of bone marrow mesenchymal/stromal progenitor (MSP) cells in these mice. In comparison to WT mice, a 10-fold decrease was observed in the number of fibroblast colony-forming units (CFU-Fs) in IL-5trg bone marrow. Hematopoietic activity of IL-5trg bone marrow cells was rescued by cultivation on preestablished layers of bone marrow-derived stromal cells. However, in contrast to bone marrow, increased hematopoietic activity was observed in the spleen and peripheral blood of IL-5trg mice. Likewise, the numbers of LTC-ICs and granulocyte-macrophage, macrophage, eosinophil, B-lymphocyte progenitors in the peripheral blood and spleen of IL-5trg mice were approximately 20-fold higher than in WT mice. A significant increase in CFU-F numbers was also observed in the spleens of IL-5trg mice compared with WT mice. Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites.

EFFECTS OF CHANGES IN ALTITUDE ON HEMATOPOIETIC ACTIVITY

Medicine ◽  
1951 ◽  
Vol 30 (3) ◽  
pp. 197-218 ◽  
Author(s):  
REX L. HUFF ◽  
JOHN H. LAWRENCE ◽  
WILLIAM E. SIRI ◽  
LOUIS R. WASSERMAN ◽  
THOMAS G. HENNESSY
Keyword(s):  
Hematopoietic Activity

scholarly journals Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia

Blood ◽  
1951 ◽  
Vol 6 (3) ◽  
pp. 228-232 ◽  
Author(s):  
ROBERT F. SCHILLING ◽  
JOHN W. HARRIS ◽  
WILLIAM B. CASTLE
Keyword(s):  
Spinal Cord ◽  
Oral Administration ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Human Gastric Juice ◽  
Vitamin B12b ◽  
Normal Human ◽  
Relationship Of ◽  
Etiologic Relationship ◽  
Hematopoietic Activity

Abstract 1. Vitamin B12a, derived from vitamin B12 by catalytic hydrogenation, is as potent a hematopoietic agent as vitamin B12 when administered parenterally to patients with pernicious anemia in relapse. 2. The hematopoietic activity of vitamin B12a, like that of vitamin B12, and of vitamin B12b, is potentiated by simultaneous oral administration with normal human gastric juice. 3. Observations on one patient suggest that vitamin B12a, like vitamin B12, will arrest the progress of subacute degeneration of the spinal cord in pernicious anemia.

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