scholarly journals Characterization and Release Kinetics of Metronidazole Loaded Silver Nanoparticles Prepared from <i>Carica papaya</i> Leaf Extract

2019 ◽  
Vol 08 (03) ◽  
pp. 47-54
Author(s):  
Tenderwealth Clement Jackson ◽  
Akeem Ayodeji Agboke ◽  
Edidiong Jumbo Udofa ◽  
Adaeze Salome Ucheokoro ◽  
Blessing Edidiong Udo ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Release Kinetics ◽  
Kinetics Of

scholarly journals Characterization and Release Kinetics of Metronidazole Loaded Silver Nanoparticles Prepared from Carica papaya Leaf Extract

2020 ◽  
Author(s):  
Tenderwealth Clement Jackson ◽  
Akeem Ayodeji Agboke ◽  
Edidiong Jumbo Udofa ◽  
Adaeze Salome Ucheokoro ◽  
Blessing Edidiong Udo ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Release Kinetics ◽  
Kinetics Of

scholarly journals Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Erika Adomavičiūtė ◽  
Solveiga Pupkevičiūtė ◽  
Vaida Juškaitė ◽  
Modestas Žilius ◽  
Sigitas Stanys ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Release Kinetics ◽  
Antibacterial Properties ◽  
Ethanolic Extract ◽  
Average Diameter ◽  
Nonwoven Material ◽  
Water Soluble ◽  
Antimicrobial Protection ◽  
Kinetics Of

An electrospun hydrophilic non-water-soluble biocompatible polylactic acid (PLA) nonwoven material was used as a delivery system for propolis ethanolic extract (PEE) and silver nanoparticles (AgNPs) that are known for their established antiseptic and antimicrobial activity. Combination of PEE and AgNPs in a single product should provide efficient antimicrobial protection and improved wound healing. Evaluations of PEE and AgNPs on morphology of electrospun materials, release kinetics of AgNPs and phenolic compounds, antibacterial properties, and cytotoxicity of electrospun PLA materials were performed. The presence of PEE or/and AgNPs resulted in denser mats formed by thicker PLA fibers. The average diameter of PLA microfibers was 168±29 nm. The average diameter of microfibers increased to 318±40 and 370±30 nm when 10 wt% and 20 wt% ethanol were added, respectively. Addition of 10 wt% or 20 wt% PEE increased the diameter to 282±25 and 371±25 nm, respectively. Suspension of AgNPs also caused the formation of thicker microfibers with 254±25 nm diameter. Electrospun PLA microfibers with PEE maintained viability of HaCaT cells. Testing of antimicrobial activity confirmed the ability of AgNPs containing PLA electrospun materials to inhibit the growth of microorganisms.

scholarly journals Preparation and characterization of sodium alginate/acrylic acid composite hydrogels conjugated to silver nanoparticles as an antibiotic delivery system

2021 ◽  
Vol 10 (1) ◽  
pp. 860-873
Author(s):  
Parvaneh Mohamadinia ◽  
Navideh Anarjan ◽  
Hoda Jafarizadeh-Malmiri
Keyword(s):  
Silver Nanoparticles ◽  
Acrylic Acid ◽  
Sodium Alginate ◽  
Release Kinetics ◽  
Silver Ions ◽  
Optimization Analysis ◽  
Composite Hydrogels ◽  
The Impact ◽  
Kinetics Of

Abstract Hydrogels are promising drug delivery systems attributable to their unique characteristics such as high hydrophilicity, controllability, biocompatibility, and facile production routines. The aim of this research was the preparation of sodium alginate/acrylic acid (AAc) composite hydrogels conjugated to silver nanoparticles to deliver the cephalexin as a model antibiotic compound. The reduction of silver ions into silver nanoparticles as well as the stabilization of created nanoparticles ensued simultaneously with hydrogel backbone formulation during microwave irradiation and monomer cross-linking processes. The impact of AAc and silver ion concentrations and the radiation time of microwave were then investigated on the main characteristics of hydrogels. The results indicated that the hydrogels’ characteristics could be significantly predicted by studying all independent parameters through various second-order polynomial models. The multiple optimization analysis suggested that the prepared hydrogels using 7.8 g AAc and 1.5 g silver nitrate and 1 min microwave radiation could give the best hydrogels with the highest swelling degree, gel fraction, cephalexin absorption, and antibacterial activity. The morphology and either absorption or release kinetics of cephalexin by the optimum prepared hydrogels were also investigated. No significant differences between the experimental and predicted data confirmed the suitability of the suggested models.

Phytochemical, hematologic and anti-tumor activity evaluations of Carica papaya leaf extract

2017 ◽  
Vol 3 (3) ◽  
Author(s):  
Hoang Nguyen ◽  
Joseph P Kitzmiller ◽  
Pooja Khungar ◽  
Narendra Dabbade ◽  
Kieu Tho Nguyen ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
Anti Tumor Activity

Analgesic Effectivty Of Nanoparticles Chitosan-Ethanol Leaf Extract Papaya (Carica Papaya L.) In White Male Mice (Mus Mucculus)

2017 ◽  
Vol 15 (2) ◽  
pp. 228
Author(s):  
Juliferd Gredi ◽  
Wintari Taurina ◽  
Mohamad Andrie
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
White Male ◽  
Ethanol Extract ◽  
Test Method ◽  
Ionic Gelation ◽  
Male Mice ◽  
Writhing Test ◽  
Effi Ciency ◽  
Optimal Formula

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.

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