scholarly journals The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients

2016 ◽  
Vol 05 (01) ◽  
pp. 37-47 ◽  
Author(s):  
Mona Mohamed K. El-Deeb ◽  
Heba G. El-Sheredy ◽  
Ayman Farouk Mohammed
Platelets ◽  
2010 ◽  
Vol 21 (7) ◽  
pp. 541-548 ◽  
Author(s):  
Magdalena Kedzierska ◽  
Beata Olas ◽  
Barbara Wachowicz ◽  
Anna Stochmal ◽  
Wieslaw Oleszek ◽  
...  

1992 ◽  
Vol 31 (5) ◽  
pp. 569-572 ◽  
Author(s):  
Heikki M. J. Antila ◽  
Matti S. Salo ◽  
Veikko Näntö ◽  
Vainamo Nikkanen ◽  
Olli Kirvelä

1991 ◽  
Vol 46 (3) ◽  
pp. 178-181 ◽  
Author(s):  
Sanjeev K. Gupta ◽  
Vijay K. Shukla ◽  
Madho P. Vaidya ◽  
Salil K. Roy ◽  
Saroj Gupta

2014 ◽  
Vol 04 (01) ◽  
pp. 22-29 ◽  
Author(s):  
Ilaria Tresoldi ◽  
Calogero Foti ◽  
Laura Masuelli ◽  
Giovanni Vanni Frajese ◽  
Piero Rossi ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Mohammed Mehdi ◽  
M. K. C. Menon ◽  
Nebiyou Seyoum ◽  
Mahteme Bekele ◽  
Wondimagegn Tigeneh ◽  
...  

The exact cause of breast cancer is unknown; it is a multifactorial disease. It is the most diagnosed and the second killer cancer among women. Breast cancer can be originated from tissues of breast or secondary from other organs via metastasis. Generally, cancer cells show aberrant metabolism and oxidative stress when compared to noncancerous tissues of breast cancer patients. The current study aims at evaluating glutamate and glucose metabolism through GDH and LDH enzyme activities, oxidant, and antioxidative status among breast cancer patients attending referral hospitals of Addis Ababa, Ethiopia. Result. Catalytic activities of glutamate dehydrogenase, lactate dehydrogenase, and oxidative stress index were significantly increased in both serum (4.2 mU/ml, 78.6 mU/ml, and 3.3 : 1, resp.) and cancerous tissues (1.4 mU/ml, 111.7 mU/ml, and 2.15 : 1, resp.) of breast cancer patients as compared to those in serum of control group (3.15 mU/ml, 30.4 mU/ml, and 2.05 : 1, resp.) and noncancerous tissues of breast cancer patients (0.92 mU/ml, 70.5 mU/ml, and 1.1 : 1, resp.) (P≤0.05). Correspondingly, ratios of reduced to oxidized glutathione were significantly decreased in both serum (20 : 1) and cancerous tissues (23.5 : 1) of breast cancer patients when compared to those in serum of control group (104.5 : 1) and noncancerous tissues of breast cancer patients (70.9 : 1) (P≤0.05). Conclusion. Catalytic activities of GDH and LDH, ratios of GSH to GSSG, and concentration of TOS among breast cancer patients were significantly higher than were those among control group and noncancerous tissues of breast cancer patients, while TAC of breast cancer patients is significantly lower than that of control group and normal tissues of breast cancer patients.


Author(s):  
Partha Basu ◽  
Richa Tripathi ◽  
Ravi Mehrotra ◽  
Koninika Ray ◽  
Anurag Srivastava ◽  
...  

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 205
Author(s):  
Carmen Griñan-Lison ◽  
Jose L. Blaya-Cánovas ◽  
Araceli López-Tejada ◽  
Marta Ávalos-Moreno ◽  
Alba Navarro-Ocón ◽  
...  

Breast cancer is the most frequent cancer and the leading cause of cancer death in women. Oxidative stress and the generation of reactive oxygen species (ROS) have been related to cancer progression. Compared to their normal counterparts, tumor cells show higher ROS levels and tight regulation of REDOX homeostasis to maintain a low degree of oxidative stress. Traditionally antioxidants have been extensively investigated to counteract breast carcinogenesis and tumor progression as chemopreventive agents; however, there is growing evidence indicating their potential as adjuvants for the treatment of breast cancer. Aimed to elucidate whether antioxidants could be a reality in the management of breast cancer patients, this review focuses on the latest investigations regarding the ambivalent role of antioxidants in the development of breast cancer, with special attention to the results derived from clinical trials, as well as their potential use as plausible agents in combination therapy and their power to ameliorate the side effects attributed to standard therapeutics. Data retrieved herein suggest that antioxidants play an important role in breast cancer prevention and the improvement of therapeutic efficacy; nevertheless, appropriate patient stratification based on “redoxidomics” or tumor subtype is mandatory in order to define the dosage for future standardized and personalized treatments of patients.


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