scholarly journals Activation of the corticotropin-releasing factor receptor from the basolateral or central amygdala modulates nociception in guinea pigs

2013 ◽  
Vol 04 (06) ◽  
pp. 20-27
Author(s):  
Alberto Ferreira Donatti ◽  
Christie Ramos Andrade Leite-Panissi
Keyword(s):  
Guinea Pigs ◽  
Corticotropin Releasing Factor ◽  
Central Amygdala

scholarly journals Activation of corticotropin releasing factor-containing neurons in the rat central amygdala and bed nucleus of the stria terminalis following exposure to two different anxiogenic stressors

2016 ◽  
Vol 304 ◽  
pp. 92-101 ◽  
Author(s):  
Ryan K. Butler ◽  
Elisabeth M. Oliver ◽  
Amanda C. Sharko ◽  
Jeffrey Parilla-Carrero ◽  
Kris F. Kaigler ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Stria Terminalis ◽  
Central Amygdala ◽  
Bed Nucleus

scholarly journals The Role of Central Amygdala Corticotropin-Releasing Factor in Predator Odor Stress-Induced Avoidance Behavior and Escalated Alcohol Drinking in Rats

2019 ◽  
Author(s):  
Marcus M. Weera ◽  
Allyson L. Schreiber ◽  
Elizabeth M. Avegno ◽  
Nicholas W. Gilpin
Keyword(s):  
Alcohol Drinking ◽  
Avoidance Behavior ◽  
Conditioned Avoidance ◽  
Corticotropin Releasing Factor ◽  
Predator Odor ◽  
Central Amygdala ◽  
Post Traumatic Stress ◽  
Conditioned Place Avoidance ◽  
Place Avoidance ◽  
Post Traumatic

ABSTRACTPost-traumatic stress disorder (PTSD) is characterized by avoidance of trauma-associated stimuli and amygdala hyperreactivity, and is highly co-morbid with alcohol use disorder (AUD). Our lab uses a predator odor (bobcat urine) stress model that produces conditioned avoidance of an odor-paired context in a subset of rats, mirroring avoidance symptoms that manifest in some but not all humans exposed to trauma. We previously showed that after predator odor stress, Avoiders exhibit escalated alcohol drinking, higher aversion-resistant operant alcohol responding, hyperalgesia, and greater anxiety-like behavior compared to unstressed Controls. We also showed that systemic antagonism of corticotropin-releasing factor-1 receptors (CRFR1) reduced escalation of alcohol drinking in rats not indexed for avoidance, that corticotropin-releasing factor (CRF) infusions into the central amygdala (CeA) produced conditioned place avoidance in stress-naïve rats, and that intra-CeA infusion of a CRFR1 antagonist reduced hyperalgesia in Avoiders. Here, we show that avoidance behavior is persistent after repeated predator odor exposure and is resistant to extinction. In addition, Avoiders showed lower weight gain than Controls after predator odor re-exposure. In the brain, higher avoidance was correlated with higher number of c-Fos+ cells and CRF immunoreactivity in the CeA. Finally, we show that intra-CeA CRFR1 antagonism reversed post-stress escalation of alcohol drinking and reduced avoidance behavior in Avoiders. Collectively, these findings suggest that elucidation of the mechanisms by which CRFR1-gated CeA circuits regulate avoidance behavior and alcohol drinking may lead to better understanding of the neural mechanisms underlying co-morbid PTSD and AUD.

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