scholarly journals Changes in the levels of CAM kinase II and synapsin I caused by oxidative stress in the rat brain, and its prevention by vitamin E

2012 ◽  
Vol 03 (08) ◽  
pp. 1199-1205 ◽  
Author(s):  
Nozomi Kaneai ◽  
Koji Fukui ◽  
Taisuke Koike ◽  
Shiro Urano
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Rat Brain ◽  
Synapsin I ◽  
Cam Kinase Ii ◽  
Cam Kinase

scholarly journals Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1777
Author(s):  
Anne-Laure Dinel ◽  
Céline Lucas ◽  
Damien Guillemet ◽  
Sophie Layé ◽  
Véronique Pallet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Morris Water Maze ◽  
Neuronal Activity ◽  
Water Maze ◽  
Salvia Officinalis ◽  
Cam Kinase Ii ◽  
Cam Kinase ◽  
Y Maze ◽  
The Impact

Background: Two different species of sage, Salvia officinalis and Salvia lavandulaefolia, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and positively impacted. Objective: Our objective is to explore the potential of these Salvia, and their additional activities, in healthy situations, and during prolonged administration, on memory and subsequent mechanisms of action related to putative effects. Design: This mouse study has implicated four investigational arms dedicated to control, Salvia officinalis aqueous extract, Salvia lavandulaefolia-encapsulated essential oil and a mix thereof (Cognivia™) for 2 weeks of administration. Cognitive functions have been assessed throughout Y-maze and Morris water maze models. The impact of supplementation on lipid peroxidation, oxidative stress, neurogenesis, neuronal activity, neurotrophins, neurotrophin receptors, CaM kinase II and glucocorticoid receptors has been assessed via post-interventional tissue collection. Results: All Salvia groups had a significant effect on Y-maze markers on day 1 of administration. Only the mix of two Salvia species demonstrated significant improvements in Morris water maze markers at the end of administration. Considering all biological and histological markers, we did not observe any significant effect of S. officinalis, S. lavandulaefolia and a mix of Salvia supplementation on lipid peroxidation, oxidative stress and neuronal plasticity (neurogenesis, neuronal activity, neurotrophins). Interestingly, CaM kinase II protein expression is significantly increased in animals supplemented with Salvia. Conclusion: The activities of Salvia alone after one intake have been confirmed; however, a particular combination of different types of Salvia have been shown to improve memory and present specific synergistic effects after chronic administration in healthy mice.

Long-term treatment with s-adenosylmethionine induces changes in presynaptic cam kinase II and synapsin I

2001 ◽  
Vol 50 (5) ◽  
pp. 337-344 ◽  
Author(s):  
Elena Consogno ◽  
Ettore Tiraboschi ◽  
Emilio Iuliano ◽  
Massimo Gennarelli ◽  
Giorgio Racagni ◽  
...  
Keyword(s):  
Term Treatment ◽  
Synapsin I ◽  
Cam Kinase Ii ◽  
Cam Kinase ◽  
Long Term Treatment

scholarly journals Kinase activity associated with caldesmon is Ca2+/calmodulin-dependent kinase II

1990 ◽  
Vol 268 (2) ◽  
pp. 367-370 ◽  
Author(s):  
G C Scott-Woo ◽  
C Sutherland ◽  
M P Walsh
Keyword(s):  
Protein Kinase ◽  
Maximal Activity ◽  
Bovine Brain ◽  
Synapsin I ◽  
Cam Kinase Ii ◽  
Cam Kinase ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Kinase Phosphorylation ◽  
Relationship Of

The relationship of the kinase which co-purifies with caldesmon to Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) was investigated by studying the phosphorylation of bovine brain synapsin I, as well-characterized substrate of CaM-kinase II. Synapsin I is a very good substrate (Km = 90 nM) of the co-purifying kinase, which phosphorylates two sites in synapsin I, both of which are distinct from the single site phosphorylated by cyclic-AMP-dependent protein kinase. Phosphorylation of synapsin I is Ca2(+)- and calmodulin-dependent: half-maximal activation occurs at 0.13 microM-Ca2+ and maximal activity at 0.4 microM-Ca2+. Phosphorylation of the co-purifying kinase slightly enhances the rate, but does not alter the stoichiometry, of subsequent synapsin I phosphorylation; it does, however, circumvent the requirement for Ca2+ and calmodulin. The properties of this kinase therefore closely resemble those of CaM-kinase II, and we conclude that it is probably a smooth-muscle isoenzyme of CaM-kinase II.

scholarly journals Increased F2-Isoprostane Levels in the Rat Brain and Plasma Caused by Oxidative Stress and Aging, and Inhibitory Effect of Vitamin E

2006 ◽  
Vol 38 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Tomoko Nishio ◽  
Ryota Miyadera ◽  
Ryuta Sakai ◽  
Kouichi Abe ◽  
Hideko Kanazawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Rat Brain ◽  
Inhibitory Effect

Hypothermia inhibits translocation of CaM kinase II and PKC-?, ?, ? isoforms and fodrin proteolysis in rat brain synaptosome during ischemia-reperfusion

2002 ◽  
Vol 67 (5) ◽  
pp. 664-669 ◽  
Author(s):  
Kazuki Harada ◽  
Tsuyoshi Maekawa ◽  
Ryosuke Tsuruta ◽  
Tadashi Kaneko ◽  
Daikai Sadamitsu ◽  
...  
Keyword(s):  
Rat Brain ◽  
Ischemia Reperfusion ◽  
Cam Kinase Ii ◽  
Cam Kinase ◽  
Pkc Isoforms
Sign in / Sign up

Export Citation Format

Share Document