scholarly journals The Effects of Standardized Ginkgo Biloba Extracts (GBE) on Subjective Cognitive Decline (SCD) in Middle-Aged Adults: A Review

2020 ◽  
Vol 09 (03) ◽  
pp. 45-65 ◽  
Author(s):  
Joerg Gruenwald ◽  
Anne Eckert ◽  
Reto W. Kressig
Keyword(s):  
Cognitive Decline ◽  
Ginkgo Biloba ◽  
Subjective Cognitive Decline ◽  
Middle Aged ◽  
Ginkgo Biloba Extracts ◽  
Middle Aged Adults

scholarly journals CHRONIC DISEASES IN MIDDLE-AGED ADULTS WITH SUBJECTIVE COGNITIVE DECLINE: UNITED STATES, 2015-2017

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S815-S816
Author(s):  
Christopher A Taylor ◽  
Erin D Bouldin ◽  
Lisa C McGuire
Keyword(s):  
Health Care ◽  
Chronic Disease ◽  
Cognitive Decline ◽  
Chronic Diseases ◽  
Chronic Conditions ◽  
Cognitive Status ◽  
Subjective Cognitive Decline ◽  
Middle Aged ◽  
Memory Problems ◽  
Middle Aged Adults

Abstract While adults aged 65 years and older are most at risk for chronic conditions, studies show that middle-aged adults aged 45–64 years also have growing numbers of comorbid chronic diseases. Regardless of age, managing chronic conditions requires decision-making abilities to manage treatments effectively. Symptoms of memory loss and confusion may impair a person’s ability to manage their health. This study examined chronic conditions in persons with subjective cognitive decline (SCD), defined as the self-reported experience of increased memory problems or confusion. Behavioral Risk Factor Surveillance System data from 2015–2017 were used to define SCD and disease status for eight chronic conditions (heart disease, stroke, cancer, arthritis, asthma, depression, diabetes, and chronic obstructive pulmonary disease) for adults 45–64 years from 49 states, District of Columbia, and Puerto Rico that collected data on cognitive decline. Among adults aged 45–64 years, 10.8% reported SCD. Among those with SCD, 77.4% had at least one chronic disease compared to 47.1% of those without SCD. Those with SCD had a higher prevalence for all eight conditions compared to those similarly-aged without SCD. Adults with at least one chronic condition were more likely to discuss their symptoms of SCD with a health care professional (54.2%) compared to those with no chronic conditions (30.3%). Poor management of chronic conditions can result in increased health care costs and might worsen existing symptoms of confusion and memory problems. Self-care interventions for chronic disease management should consider the importance of an individual’s cognitive status, including SCD.

scholarly journals Purpose in life is a robust protective factor of reported cognitive decline among late middle-aged adults: The Emory Healthy Aging Study

2020 ◽  
Vol 263 ◽  
pp. 310-317 ◽  
Author(s):  
Aliza P. Wingo ◽  
Thomas S. Wingo ◽  
Wen Fan ◽  
Sharon Bergquist ◽  
Alvaro Alonso ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Healthy Aging ◽  
Protective Factor ◽  
Purpose In Life ◽  
Middle Aged ◽  
Aging Study ◽  
Middle Aged Adults

scholarly journals Peripheral Inflammation and Cognitive Performance in Middle-Aged Adults With and Without Type 2 Diabetes: Results From the ENBIND Study

2020 ◽  
Vol 12 ◽  
Author(s):  
Adam H. Dyer ◽  
Louise McKenna ◽  
Isabella Batten ◽  
Karen Jones ◽  
Matthew Widdowson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Interaction Analysis ◽  
Peripheral Inflammation ◽  
Older Individuals ◽  
Middle Aged ◽  
Tnf Α ◽  
Middle Aged Adults

Midlife Type 2 Diabetes Mellitus (T2DM) is associated with a greater risk of dementia in later life. Peripheral inflammation and its impact on cognition is proposed as one of the pathological mechanisms mediating this link. However, studies have primarily focused on older individuals with established cognitive impairment and a long duration of T2DM. Importantly, knowledge of which individuals with midlife T2DM who are at greatest risk of later cognitive decline is lacking. We examined the cross-sectional relationship between serum levels of 8 pro-inflammatory markers (IL-1β, IL-6, TNF-α, IL-8, MCP-1, CXCL10, IL-12p70, CRP) and performance on a detailed neuropsychological assessment battery in middle-aged adults with uncomplicated T2DM (N = 89; 52 ± 8.1 years, 47% female) and matched healthy controls (N = 50; 52 ± 8.3 years, 59% female). Linear regression was used to analyze associations between serum markers and cognitive performance in the overall cohort, followed by a T2DM∗protein concentration interaction analysis to identify any T2DM-specific effects. We observed a significant T2DM-specific association between serum TNF-α levels and scores on the Paired Associates Learning (PAL) task (β: −3.16, SE: 1.32, p = 0.01, Std. Beta: −0.94), a task with significant working memory demands previously implicated in T2DM-related cognitive dysfunction. However, this did not persist on controlling for multiple testing. We provide exploratory evidence for a significant T2DM-specific relationship between serum TNF-α and memory performance. These findings require further replication and longitudinal analysis with the aim of selecting-out individuals with midlife T2DM at risk of future cognitive decline for potential preventative interventions.

Vitamin K status is not associated with cognitive decline in middle aged adults

2015 ◽  
Vol 19 (9) ◽  
pp. 908-912 ◽  
Author(s):  
E. G. H. M. van den Heuvel ◽  
N. M. van Schoor ◽  
C. Vermeer ◽  
R. M. L. Zwijsen ◽  
M. den Heijer ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Vitamin K ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals Cognitive Decline and Oral Health in Middle-aged Adults in the ARIC Study

2013 ◽  
Vol 92 (9) ◽  
pp. 795-801 ◽  
Author(s):  
S. Naorungroj ◽  
G.D. Slade ◽  
J.D. Beck ◽  
T.H. Mosley ◽  
R.F. Gottesman ◽  
...  
Keyword(s):  
Oral Health ◽  
Cognitive Decline ◽  
Middle Aged ◽  
Middle Aged Adults ◽  
Aric Study

[P2-205]: DEDUCTIVE MODE FINDING: TRACING BACK COGNITIVE DECLINE IN BIOMARKER POSITIVE MIDDLE-AGED ADULTS

2017 ◽  
Vol 13 (7S_Part_14) ◽  
pp. P685-P686
Author(s):  
Vamsi K. Ithapu ◽  
Lindsay R. Clark ◽  
Rebecca L. Koscik ◽  
Vikas Singh ◽  
Sterling C. Johnson
Keyword(s):  
Cognitive Decline ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals Flavonol Intake and Cognitive Decline in Middle-Aged Adults

2015 ◽  
Vol 18 (12) ◽  
pp. 1327-1332 ◽  
Author(s):  
Martin Root ◽  
Erin Ravine ◽  
Anne Harper
Keyword(s):  
Cognitive Decline ◽  
Middle Aged ◽  
Middle Aged Adults
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