scholarly journals Failure to Recover from Proactive Semantic Interference Differentiates Amnestic Mild Cognitive Impairment and PreMCI from Normal Aging after Adjusting for Initial Learning Ability

2018 ◽  
Vol 07 (02) ◽  
pp. 50-61
Author(s):  
Rosie E. Curiel ◽  
Elizabeth A. Crocco ◽  
Arlene Raffo ◽  
Salvador M. Guinjoan ◽  
Charles Nemeroff ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Normal Aging ◽  
Amnestic Mild Cognitive Impairment ◽  
Learning Ability ◽  
Semantic Interference ◽  
Initial Learning

P300 responses are associated with subcortical gray matter volume in amnestic mild cognitive impairment and normal aging

2016 ◽  
Vol 108 ◽  
pp. 100
Author(s):  
Derya Durusu Emek-Sava ◽  
Berrin Çavuşoğlu ◽  
Duygu Hünerli ◽  
Deniz Yerlikaya ◽  
Arife Gökçeoğlu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Normal Aging ◽  
Amnestic Mild Cognitive Impairment ◽  
Matter Volume

scholarly journals Amnestic Mild Cognitive Impairment is Characterized by the Inability to Recover from Proactive Semantic Interference across Multiple Learning Trials

2020 ◽  
pp. 1-7
Author(s):  
D.A. Loewenstein ◽  
R.E. Curiel Cid ◽  
M. Kitaigorodsky ◽  
E.A. Crocco ◽  
D.D. Zheng ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Stress Test ◽  
Amnestic Mild Cognitive Impairment ◽  
Semantic Interference ◽  
Cognitive Stress ◽  
Learning Trials ◽  
Receiver Operating

Background: Difficulties in inhibition and self-monitoring are early features of incipient Alzheimer’s disease and may manifest as susceptibility to proactive semantic interference. However, due to limitations of traditional memory assessment paradigms, recovery from interference effects following repeated learning opportunities has not been explored. Objective: This study employed a novel computerized list learning test consisting of repeated learning trials to assess recovery from proactive and retroactive semantic interference. Design: The design was cross-sectional. Setting: Participants were recruited from the community as part of a longitudinal study on normal and abnormal aging. Participants: The sample consisted of 46 cognitively normal individuals and 30 participants with amnestic mild cognitive impairment. Measurements: Participants were administered the Cognitive Stress Test and traditional neuropsychological measures. Step-wise logistic regression was applied to determine which Cognitive Stress Test measures best discriminated between diagnostic groups. This was followed by receiver operating characteristic analyses. Results: Cued A3 recall, Cued B3 recall and Cued B2 intrusions were all independent predictors of diagnostic status. The overall predictive utility of the model yielded 75.9% sensitivity, 91.1% specificity, and an overall correct classification rate of 85.1%. When these variables were jointly entered into receiver operating characteristic analyses, the area under the curve was .923 (p<.001). Conclusions: This novel paradigm’s use of repeated learning trials offers a unique opportunity to assess recovery from proactive and retroactive semantic interference. Participants with mild cognitive impairment exhibited a continued failure to recover from proactive interference that could not be explained by mere learning deficits.

scholarly journals A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48973 ◽  
Author(s):  
Zhijun Yao ◽  
Bin Hu ◽  
Chuanjiang Liang ◽  
Lina Zhao ◽  
Mike Jackson ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Study ◽  
Cortical Thickness ◽  
Normal Aging ◽  
Amnestic Mild Cognitive Impairment
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