scholarly journals Spatial structure of beta-amyloid Aβ<sub>1-40</sub> in complex with a biological membrane model

2012 ◽  
Vol 01 (03) ◽  
pp. 22-29 ◽  
Author(s):  
Konstantin S. Usachev ◽  
Andrey V. Filippov ◽  
Oleg N. Antzutkin ◽  
Vladimir V. Klochkov
Keyword(s):  
Spatial Structure ◽  
Biological Membrane ◽  
Beta Amyloid ◽  
Membrane Model ◽  
Amyloid Aβ

Spatial structure of heptapeptide Aβ16-22(beta-amyloid Aβ1-40active fragment) in solution and in complex with a biological membrane model

2012 ◽  
Vol 50 (12) ◽  
pp. 784-792 ◽  
Author(s):  
Konstantin S. Usachev ◽  
Sergej V. Efimov ◽  
Ajdar R. Yulmetov ◽  
Andrey V. Filippov ◽  
Oleg N. Antzutkin ◽  
...  
Keyword(s):  
Spatial Structure ◽  
Biological Membrane ◽  
Beta Amyloid ◽  
Membrane Model

scholarly journals Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Wen Fu ◽  
Vlatka Vukojevic ◽  
Aarti Patel ◽  
Rania Soudy ◽  
David MacTavish ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Amyloid Aβ

Understanding the structural requirements of cyclic sulfone hydroxyethylamines as hBACE1 inhibitors against Aβ plaques in Alzheimer's disease: a predictive QSAR approach

RSC Advances ◽  
2016 ◽  
Vol 6 (34) ◽  
pp. 28171-28186 ◽  
Author(s):  
Pravin Ambure ◽  
Kunal Roy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Structural Requirements ◽  
Amyloid Aβ

Beta (β)-site amyloid precursor protein cleaving enzyme 1 (BACE1) is one of the most important targets in Alzheimer's disease (AD), which is responsible for production and accumulation of beta amyloid (Aβ).

scholarly journals Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer’s disease model

2020 ◽  
Author(s):  
Youngsun Lee ◽  
Yoori Choi ◽  
Eun-Joo Park ◽  
Seokjun Kwon ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Disease Model ◽  
Early Period ◽  
Beta Amyloid ◽  
Lymphatic Drainage ◽  
Beneficial Effects ◽  
Age Related ◽  
Early Dementia ◽  
Amyloid Aβ ◽  
Brain Homeostasis

AbstractDrainage of parenchymal waste through the lymphatic system maintains brain homeostasis. Age-related changes of glymphatic-lymphatic clearance lead to the accumulation beta-amyloid (Aβ) in dementia models. In this study, focused ultrasound treatment in combination with microbubbles (FUS-MB) improved Aβ drainage in early dementia model mice, 5XFAD. FUS-MB enhanced solute Aβ clearance from brain, but not plaques, to cerebrospinal fluid (CSF) space and then deep cervical lymph node (dCLN). dCLN ligation exaggerated memory impairment and progress of plaque formation and also the beneficial effects of FUS-MB upon Aβ removal through CSF-lymphatic routes. In this ligation model, FUS-MB improved memory despite accumulation of Aβ in CSF. In conclusion, FUS-MB enhances glymphatic-lymphatic clearance of Aβ mainly by increasing brain-to-CSF Aβ drainage. We suggest that FUS-MB can delay dementia progress in early period and benefits of FUS-MB depend on the effect of Aβ disposal through CSF-lymphatics.

Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells

2021 ◽  
Vol 18 (1) ◽  
pp. 80-87
Author(s):  
Elaine W.L. Chan ◽  
Emilia T.Y. Yeo ◽  
Kelly W.L. Wong ◽  
Mun L. See ◽  
Ka Y. Wong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Amyloid ◽  
Mechanistic Study ◽  
Tau Hyperphosphorylation ◽  
Neuroprotective Effects ◽  
Human Neuroblastoma ◽  
Hexane Extracts ◽  
Anti Oxidant ◽  
Amyloid Aβ

Background: In Alzheimer’s disease, accumulation of beta amyloid (Aβ) triggers amyloidogenesis and hyperphosphorylation of tau protein leading to neuronal cell death. Piper sarmentosum Roxb. (PS) is a traditional medicinal herb used by Malay to treat rheumatism, headache and boost memory. It possesses various biological effects, such as anti-cholinergic, anti-inflammatory, anti-oxidant and anti-depressant-like effects. Objective: The present study aimed to investigate neuroprotective properties of PS against Aβ-induced neurotoxicity and to evaluate its potential mechanism of action. Methods: Neuroprotective effects of hexane (HXN), dichloromethane (DCM), ethyl acetate (EA) and methanol (MEOH) extracts from leaves (L) and roots (R) of PS against Aβ-induced neurotoxicity were investigated in SH-SY5Y human neuroblastoma cells. Cells were pre-treated with PS for 24 h followed by 24 h of induction with Aβ. The neuroprotective effects of PS were studied using cell viability and cellular reactive oxygen species (ROS) assays. The levels of extracellular Aβ and tau proteins phosphorylated at threonine 231 (pT231) were determined. Gene and protein expressions were assessed using qRT-PCR analyses and western blot analyses, respectively. Results: Hexane extracts of PS (LHXN and RHXN) protected SH-SY5Y cells against Aβ-induced neurotoxicity, and decreased levels of extracellular Aβ and phosphorylated tau (pT231). Although extracts of PS inhibited Aβ-induced ROS production, it was unlikely that neuroprotective effects were simply due to the anti-oxidant capacity of PS. Further, mechanistic study suggested that the neuroprotective effects of PS might be due to its capability to regulate amyloidogenesis through the downregulation of BACE and APP. Conclusion: These findings suggest that hexane extracts of PS confer neuroprotection against Aβ- induced neurotoxicity in SH-SY5Y cells by attenuating amyloidogenesis and tau hyperphosphorylation. Due to its neuroprotective properties, PS might be a potential therapeutic agent for Alzheimer’s disease.

The biophysical interaction of ferulic acid with liposomes as biological membrane model: The effect of the lipid bilayer composition

2020 ◽  
pp. 114689
Author(s):  
Stéphanie Andrade ◽  
Maria João Ramalho ◽  
Joana Angélica Loureiro ◽  
Maria Carmo Pereira
Keyword(s):  
Ferulic Acid ◽  
Lipid Bilayer ◽  
Biological Membrane ◽  
Membrane Model

scholarly journals Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

2011 ◽  
Vol 8 (1) ◽  
pp. 79 ◽  
Author(s):  
Adam D Bachstetter ◽  
Bin Xing ◽  
Lucia de Almeida ◽  
Edgardo R Dimayuga ◽  
D Martin Watterson ◽  
...  
Keyword(s):  
Proinflammatory Cytokine ◽  
Beta Amyloid ◽  
Toll Like Receptor ◽  
P38α Mapk ◽  
Amyloid Aβ

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies

2015 ◽  
Vol 76 ◽  
pp. 81-90 ◽  
Author(s):  
Giuseppe Verdile ◽  
Prita R. Asih ◽  
Anna M. Barron ◽  
Eka.J. Wahjoepramono ◽  
Lars M. Ittner ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Clinical Studies ◽  
Beta Amyloid ◽  
Amyloid Aβ ◽  
The Impact
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