Recent Trends in High-Performance Computing for Computational Fluid Dynamics

2009 ◽  
pp. 351-368
Author(s):  
D.C. Sternel ◽  
M. Schäfer
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
High Performance Computing ◽  
High Performance ◽  
Recent Trends ◽  
Performance Computing

scholarly journals A computational fluid dynamics simulation framework for ventricular catheter design optimization

2018 ◽  
Vol 129 (4) ◽  
pp. 1067-1077 ◽  
Author(s):  
Sofy H. Weisenberg ◽  
Stephanie C. TerMaath ◽  
Charlotte N. Barbier ◽  
Judith C. Hill ◽  
James A. Killeffer
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Standard Deviation ◽  
High Performance Computing ◽  
High Performance ◽  
Ventricular Catheter ◽  
Simulation Framework ◽  
Flow Rates ◽  
Catheter Design ◽  
Performance Computing

OBJECTIVECerebrospinal fluid (CSF) shunts are the primary treatment for patients suffering from hydrocephalus. While proven effective in symptom relief, these shunt systems are plagued by high failure rates and often require repeated revision surgeries to replace malfunctioning components. One of the leading causes of CSF shunt failure is obstruction of the ventricular catheter by aggregations of cells, proteins, blood clots, or fronds of choroid plexus that occlude the catheter’s small inlet holes or even the full internal catheter lumen. Such obstructions can disrupt CSF diversion out of the ventricular system or impede it entirely. Previous studies have suggested that altering the catheter’s fluid dynamics may help to reduce the likelihood of complete ventricular catheter failure caused by obstruction. However, systematic correlation between a ventricular catheter’s design parameters and its performance, specifically its likelihood to become occluded, still remains unknown. Therefore, an automated, open-source computational fluid dynamics (CFD) simulation framework was developed for use in the medical community to determine optimized ventricular catheter designs and to rapidly explore parameter influence for a given flow objective.METHODSThe computational framework was developed by coupling a 3D CFD solver and an iterative optimization algorithm and was implemented in a high-performance computing environment. The capabilities of the framework were demonstrated by computing an optimized ventricular catheter design that provides uniform flow rates through the catheter’s inlet holes, a common design objective in the literature. The baseline computational model was validated using 3D nuclear imaging to provide flow velocities at the inlet holes and through the catheter.RESULTSThe optimized catheter design achieved through use of the automated simulation framework improved significantly on previous attempts to reach a uniform inlet flow rate distribution using the standard catheter hole configuration as a baseline. While the standard ventricular catheter design featuring uniform inlet hole diameters and hole spacing has a standard deviation of 14.27% for the inlet flow rates, the optimized design has a standard deviation of 0.30%.CONCLUSIONSThis customizable framework, paired with high-performance computing, provides a rapid method of design testing to solve complex flow problems. While a relatively simplified ventricular catheter model was used to demonstrate the framework, the computational approach is applicable to any baseline catheter model, and it is easily adapted to optimize catheters for the unique needs of different patients as well as for other fluid-based medical devices.

Recent trends in high performance computing

2009 ◽  
pp. 93-107
Author(s):  
Jack J. Dongarra ◽  
Hans W. Meuer ◽  
Horst D. Simon ◽  
Erich Strohmaier
Keyword(s):  
High Performance Computing ◽  
High Performance ◽  
Recent Trends ◽  
Performance Computing
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