Vibration Analysis of a Production Platform induced by Mechanical Equipment

2010 ◽  
Author(s):  
B.D. Rimola ◽  
J.G.S. da Silva ◽  
A.C.C.F. Sieira ◽  
L.R.O. de Lima ◽  
L.F. da C. Neves
Keyword(s):  
Vibration Analysis ◽  
Mechanical Equipment ◽  
Production Platform

scholarly journals Vibration Analysis of an Oil Production Platform Submitted to Dynamic Actions Induced by Mechanical Equipment

10.5772/23236 ◽  
2011 ◽  
Author(s):  
Jose Guilherme Santos da Silva ◽  
Ana Cristina Castro Fontenla Sieira ◽  
Luciano Rodrigues Ornelas de Lima ◽  
Bruno Dias
Keyword(s):  
Vibration Analysis ◽  
Oil Production ◽  
Mechanical Equipment ◽  
Production Platform

scholarly journals Investigation of vibroactivity of the mechanical equipment aiming to reduce emitting noise

Mechanika ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 51-54
Author(s):  
Robertas Mikalauskas
Keyword(s):  
Human Health ◽  
Sound Pressure Level ◽  
Vibration Analysis ◽  
Occupational Diseases ◽  
Sound Pressure ◽  
Structural Changes ◽  
Pressure Level ◽  
Mechanical Equipment ◽  
Field Management ◽  
Vibration Parameters

At present, the noise problem is already widely discussed and identified as a priority to ensure human health and the prevention of occupational diseases. We understand acoustic field management as a targeted use of actions and tools to change field parameters or characteristics. In general, the most effective effects on the fields are the elimination of their generation conditions. In this work the vibration analysis of the recuperators was performed, the limits of the vibration parameters were determined and the correlation between the vibration activity of the device and the sound pressure level in the near environment was determined. After the design of the fan partitions and the airflow excitation of the fans with respect to vibration parameters, it was found that the above mentioned structural changes allowed to reduce the average total weighted sound pressure level in the vicinity by 8%.

scholarly journals Vibration Analysis and Fatigue Assessment of Floors. Part II: Mechanical Equipment

2021 ◽  
Vol 15 (10) ◽  
Author(s):  
Ana C. S. da Silva ◽  
Gabriel M. Sant’Anna ◽  
Lucia H. G. Cardoso ◽  
André V. Castilho ◽  
José G. S. da Silva
Keyword(s):  
Vibration Analysis ◽  
Mechanical Equipment ◽  
Fatigue Assessment

Metabolic engineering of CHO cells to prepare glycoproteins

2018 ◽  
Vol 2 (3) ◽  
pp. 433-442 ◽  
Author(s):  
Qiong Wang ◽  
Michael J. Betenbaugh
Keyword(s):  
Metabolic Engineering ◽  
Cho Cells ◽  
Genetic Manipulation ◽  
Chinese Hamster ◽  
Post Translational Modification ◽  
Effector Functions ◽  
Recombinant Glycoproteins ◽  
Production Platform ◽  
Chemical Inhibitors ◽  
Amino Acid Mutations

As a complex and common post-translational modification, N-linked glycosylation affects a recombinant glycoprotein's biological activity and efficacy. For example, the α1,6-fucosylation significantly affects antibody-dependent cellular cytotoxicity and α2,6-sialylation is critical for antibody anti-inflammatory activity. Terminal sialylation is important for a glycoprotein's circulatory half-life. Chinese hamster ovary (CHO) cells are currently the predominant recombinant protein production platform, and, in this review, the characteristics of CHO glycosylation are summarized. Moreover, recent and current metabolic engineering strategies for tailoring glycoprotein fucosylation and sialylation in CHO cells, intensely investigated in the past decades, are described. One approach for reducing α1,6-fucosylation is through inhibiting fucosyltransferase (FUT8) expression by knockdown and knockout methods. Another approach to modulate fucosylation is through inhibition of multiple genes in the fucosylation biosynthesis pathway or through chemical inhibitors. To modulate antibody sialylation of the fragment crystallizable region, expressions of sialyltransferase and galactotransferase individually or together with amino acid mutations can affect antibody glycoforms and further influence antibody effector functions. The inhibition of sialidase expression and chemical supplementations are also effective and complementary approaches to improve the sialylation levels on recombinant glycoproteins. The engineering of CHO cells or protein sequence to control glycoforms to produce more homogenous glycans is an emerging topic. For modulating the glycosylation metabolic pathways, the interplay of multiple glyco-gene knockouts and knockins and the combination of multiple approaches, including genetic manipulation, protein engineering and chemical supplementation, are detailed in order to achieve specific glycan profiles on recombinant glycoproteins for superior biological function and effectiveness.

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