A Dual Energy X-ray Absorptiometry Validation of a Bone Remodelling Model for the Assessment of Osteoporotic Bone Quality

2009 ◽  
Author(s):  
L. Santos ◽  
P.G. Coelho ◽  
J.E. Fonseca ◽  
H.C. Rodrigues ◽  
P.R. Fernandes
Keyword(s):  
Bone Quality ◽  
Bone Remodelling ◽  
Dual Energy ◽  
Osteoporotic Bone ◽  
X Ray

scholarly journals Preoperative bone quality as a factor in dual-energy X-ray absorptiometry analysis comparing bone remodelling between two implant types

2006 ◽  
Vol 32 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Bart Cornelis Hendrikus van der Wal ◽  
Ali Rahmy ◽  
Bernd Grimm ◽  
Ide Heyligers ◽  
Alphons Tonino
Keyword(s):  
Bone Quality ◽  
Bone Remodelling ◽  
Dual Energy ◽  
X Ray

scholarly journals Raman spectroscopy of fingernails: A novel tool for evaluation of bone quality?

2010 ◽  
Vol 24 (5) ◽  
pp. 517-524 ◽  
Author(s):  
N. M. Cummins ◽  
J. C. C. Day ◽  
A. Wren ◽  
P. Carroll ◽  
N. Murphy ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bone Quality ◽  
Bone Remodelling ◽  
Dual Energy ◽  
Structural Proteins ◽  
Spectral Features ◽  
Mineral Density ◽  
X Ray ◽  
Large Populations ◽  
History Of

Raman data from human fingernails has been analysed to determine if a relationship exists between spectral features and bone quality. Previous work demonstrated a relationship between the manually determined intensity of the disulphide peak (Bone Quality Test; BQT) and osteoporotic fracture. A computer program is now described that automates the BQT determination for large sample-sets. In this study the ability of the automated BQT to discriminate between fractures and controls was compared to that of bone mineral density (BMD) and biomarkers of bone remodelling. Females aged 18–67 years participated in the study (n═ 159). Fingernails were analysed using Raman spectroscopy. Lumbar and Femoral BMD was measured by dual energy X-ray absorptiometry (DXA). Fasting venepuncture samples were analysed for osteocalcin and CTx (collagen C-telopeptides) by electrochemiluminescence. No correlation was found between the BQT and BMD or the biomarkers. The BQT and BMD were found to be equally accurate in identifying subjects with a history of fracture (p< 0.01) and both outperformed osteocalcin and CTx. It appears that keratin and collagen are related structural proteins that require disulphide bonding for stability. Therefore, these preliminary results suggest that Raman spectroscopy of keratin may have potential as a diagnostic tool for screening bone quality in large populations.

scholarly journals Bone quality, as measured by trabecular bone score, in patients with primary hyperparathyroidism

2013 ◽  
Vol 169 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Cristina Eller-Vainicher ◽  
Marcello Filopanti ◽  
Serena Palmieri ◽  
Fabio Massimo Ulivieri ◽  
Valentina Morelli ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Trabecular Bone ◽  
Bone Quality ◽  
Trabecular Bone Score ◽  
Dual Energy ◽  
Mineral Density ◽  
Texture Measurement ◽  
X Ray ◽  
Spinal Radiograph ◽  
And Gender

ObjectiveIn primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased bone quality. Trabecular bone score (TBS) is a texture measurement acquired during a spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index of bone micro-architecture.DesignWe studied 92 PHPT patients (74 females, age 62.1±9.7 years) and 98 control subjects. In all patients at baseline, in 20 surgically treated patients and in 10 conservatively treated patients after 24 months, TBS, spinal (lumbar spine (LS)) and femoral (total hip (TH) and femoral neck (FN)) BMD were assessed by DXA and VFx by spinal radiograph.ResultsPHPT patients had lower TBS (−2.39±1.8) and higher VFx prevalence (43.5%) than controls (−0.98±1.07 and 8.2% respectively, bothP<0.0001). TBS was associated with VFx (odds ratio 1.4, 95% CI 1.1–1.9,P=0.02), regardless of LS-BMD, age, BMI and gender, and showed a better compromise between sensitivity (75%) and specificity (61.5%) for detecting VFx than LS-BMD, TH-BMD and FN-BMD (31 and 75%, 72 and 44.2%, and 64 and 65% respectively). In surgically treated patients, TBS, LS-BMD, TH-BMD and FN-BMD increased (+47±44.8,+29.2±34.1,+49.4±48.7 and +30.2±39.3% respectively, allP<0.0001). Among patients treated conservatively, TBS decreased significantly in those (n=3) with incident VFx (−1.3±0.3) compared with those without (−0.01±0.9,P=0.048), while BMD changes were not statistically different (LS 0.3±1.2 vs −0.8±0.9 respectively,P=0.19; TH 0.4±0.8 vs −0.8±1.4 respectively,P=0.13 and FN 0.4±0.9 vs −0.8±1.4 respectively,P=0.14).ConclusionsIn PHPT, bone quality, as measured by TBS, is reduced and associated with VFx and improves after surgery.

scholarly journals Poor correlations between measurements of bone quality by quantitative ultrasound sonography and dual energy X-ray absorptiometry in patients with β-thalassaemia major

2009 ◽  
Vol 82 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Athanasios Christoforidis ◽  
Vassilios Perifanis ◽  
Eleni Papadopoulou ◽  
Meropi Dimitriadou ◽  
Eirini Kazantzidou ◽  
...  
Keyword(s):  
Bone Quality ◽  
Quantitative Ultrasound ◽  
Dual Energy ◽  
Thalassaemia Major ◽  
X Ray ◽  
Ultrasound Sonography

scholarly journals Can digital X-ray radiogrammetry be an alternative for dual-energy X-ray absorptiometry in the diagnosis of secondary low bone quality in children?

2019 ◽  
Vol 178 (9) ◽  
pp. 1433-1441 ◽  
Author(s):  
Alex D. Leijten ◽  
Brieke Hampsink ◽  
Marcel Janssen ◽  
Willemijn M. Klein ◽  
Jos M. T. Draaisma
Keyword(s):  
Bone Quality ◽  
Dual Energy ◽  
X Ray

scholarly journals Bone remodelling around the Metha short stem in total hip arthroplasty: a prospective dual-energy X-ray absorptiometry study

2011 ◽  
Vol 36 (3) ◽  
pp. 533-538 ◽  
Author(s):  
Matthias Lerch ◽  
Annelene von der Haar-Tran ◽  
Henning Windhagen ◽  
Bernd A. Behrens ◽  
Patrick Wefstaedt ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Bone Remodelling ◽  
Dual Energy ◽  
Short Stem ◽  
X Ray ◽  
Total Hip
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