An Intelligent Approach to Construction Safety

2009 ◽  
Author(s):  
D.St.J. Fox ◽  
D.W. Begg ◽  
A.K. Petersen
Keyword(s):  
Construction Safety ◽  
Intelligent Approach

Organizational assessment and development in construction safety and health

2010 ◽  
Author(s):  
Konstantin Cigularov ◽  
Peter Y. Chen ◽  
David A. Hoffman ◽  
Donald Edward Eggerth
Keyword(s):  
Construction Safety ◽  
Organizational Assessment ◽  
Safety And Health

Construction Safety: An Integral Part of Project Management

2011 ◽  
Vol 4 (4) ◽  
pp. 1-4
Author(s):  
J.LIDIYA GRIVEENA ◽  
◽  
K.SRINIVASAN K.SRINIVASAN
Keyword(s):  
Project Management ◽  
Construction Safety

Neoadjuvant Chemotherapy Induces the Appearance of New Copy Number Aberrations in Breast Tumor and is Associated with Metastasis

2020 ◽  
Vol 20 (9) ◽  
pp. 681-688
Author(s):  
Nikolai V. Litviakov ◽  
Marina K. Ibragimova ◽  
Matvey M. Tsyganov ◽  
Artem V. Doroshenko ◽  
Eugeniy Y. Garbukov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Copy Number ◽  
Breast Cancer Patients ◽  
Free Survival ◽  
Luminal B ◽  
Cell Clones ◽  
Genetic Landscape ◽  
Intelligent Approach

Background: In this study, we examined the CNA-genetic landscape (CNA – copy number aberration) of breast cancer prior to and following neoadjuvant chemotherapy (NAC) and correlated changes in the tumor landscape with chemotherapy efficiency as well as metastasis-free survival. Objective: Breast cancer patients (n = 30) with luminal B molecular subtypes were treated with anthracycline- based therapy. Methods: To study CNAs in breast tumors, microarray analysis was performed. Results: Three effects of NAC on tumor CNA landscape were identified: 1 – the number of CNA-bearing tumor clones decreased following NAC; 2 – there were no alterations in the number of CNA-containing clones after NAC; 3 – the treatment with NAC increased the number of CNA-bearing clones (new clones appeared). All NAC-treated patients who had new tumor clones with amplification (20%) had a 100% likelihood of metastasis formation. In these cases, NAC contributed to the emergence of potential metastatic clones. Our study identified the following loci – 5p, 6p, 7q, 8q, 9p, 10p, 10q22.1, 13q, 16p, 18Chr and 19p – that were amplified during the treatment with NAC and may be the markers of potential metastatic clones. In other patients who showed total or partial elimination of CNA-bearing cell clones, no new amplification clones were observed after NAC, and no evidence of metastases was found with follow-up for 5 years (р = 0.00000). Conclusion: Our data suggest that the main therapeutic result from NAC is the elimination of potential metastatic clones present in the tumor before treatment. The results showed the necessity of an intelligent approach to NAC to avoid metastasis stimulation.

scholarly journals Intelligent Approach for Improvement of BIPV Systems Performance: Case Study

2019 ◽  
Vol 471 ◽  
pp. 112015
Author(s):  
Dan Craciunescu ◽  
Laurentiu Fara ◽  
Ana-Maria Dabija ◽  
Paul Sterian ◽  
Silvian Fara
Keyword(s):  
Intelligent Approach
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