The Possibility of Using Honey as Cytoprotective Against Pathological Effect of Doxorubicin Morphological Changes, Toxilogical Symptoms, Histological Structure and Functions of Mice Liver

2009 ◽  
Vol 21 (2) ◽  
pp. 395-418
Author(s):  
M. Ganash ◽  
M. Mujallid ◽  
A. Al-Robai
Keyword(s):  
Morphological Changes ◽  
Histological Structure ◽  
Pathological Effect ◽  
Mice Liver ◽  
Structure And Functions

scholarly journals Morphological changes of the liver under conditions of hyperhomocysteinemia in the background of hypo- and hyperthyroidism

2020 ◽  
Vol 26 (2) ◽  
pp. 19-25
Author(s):  
V.M. Nechyporuk ◽  
M.M. Korda ◽  
O.V. Kovalchuk
Keyword(s):  
Thyroid Dysfunction ◽  
Negative Impact ◽  
Morphological Changes ◽  
Normal Growth ◽  
Daily Administration ◽  
Histological Structure ◽  
Organ Function ◽  
Inflammatory Processes ◽  
Oxidative Processes ◽  
Structure And Functions

Thyroxine and Triiodothyronine are very important for normal growth, development and organ function. These hormones regulate the basal rate of metabolism of all cells, including hepatocytes, and thus modulate liver function. There is a close connection between hyperhomocysteinemia (HHCy) and the induction of oxidative processes, disruption of nitric oxide production of NO synthase, damage to the endoplasmic reticulum and activation of inflammatory processes in the liver. Disorders of homocysteine metabolism (HC) in thyroid dysfunction are also known. Therefore, it can be assumed that the violation of the structure and functions of the liver will be an important manifestation of the negative impact of HHCy on organs and tissues in hyper- and hypothyroidism. The aim of the study was to establish the reorganization of the structural components of the liver in the conditions of modelized HHCy, hyper- and hypothyroidism and their joint effects. Thiolactone HHCy was modelized by administering to animals an exogenous HC in the form of Thiolactone at a dose of 100 mg/kg body weight once a day for 28 days. Hyperthyroidism was modelized by daily administration of L-thyroxine at a dose of 200 μg/kg for the 21 days, hypothyroidism - daily administration of Thiamazole at a dose of 10 mg/kg for the 21 days. Individual groups of animals were administered L-thyroxine and Thiamazole in parallel with HC. It was found that in the conditions of simulated HHCy, hypo- and hyperthyroidism in the liver of experimental animals there is an incompleteness of hepatocyte beams, changes in hepatocytes of destructive, dystrophic and necrotic nature with signs of steatosis, vascular disorders. Conclusions: both HHCy and hypo- or hyperthyroidism lead to a violation of the structural organization of liver tissue. With the development of thyroid dysfunction on the background of HHCy, the disturbances of the histological structure of hepatocytes significantly increased.

scholarly journals Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice

2021 ◽  
Vol 15 (1) ◽  
pp. 52-58
Author(s):  
Najma Hameed ◽  
Khalid Farooq
Keyword(s):  
Body Weight ◽  
Morphological Changes ◽  
Isotonic Saline ◽  
Daily Basis ◽  
Protective Role ◽  
Sildenafil Citrate ◽  
Control Group ◽  
Histomorphological Changes ◽  
Mice Liver

Objectives: The objective of the study was to reveal the reversal of histo-morphological changes in mice liver induced by combined isoniazid-rifampicin (INH-RIF) therapy with sildenafil treatment. Methods: Twenty-one mice weighing between 25–35 g were enrolled in the study. Randomisation was carried out by simple balloting method. The selected mice were sorted into three groups with 7 mice, each group. In group C (n=7) control group, mice were administered 0.4ml of saline per kg body weight daily intra peritoneally for 21 days. In group R (n=7) INH-RIF group, rifampicin (50 mg/kg) and isoniazid (50 mg/kg), dissolved in 4 ml/kg isotonic saline, were administered intra-peritoneally (ip) daily for 21 days. In group S (n=7) sildenafil administered group, 10 mg/kg sildenafil was given orally by gastric gavage on daily basis along with the intraperitoneal injection of INH-RIF (50 mg/kg each) daily for 21 days. Results: Histopathology revealed hepatotoxicity in group R (INH-RIF), while significant improvement was observed in group C (INH-RIF-sildenafil). Conclusion: Sildenafil citrate possesses hepatoprotective role against INH-RIF induced hepatotoxicity.

scholarly journals Morphological changes in the skin of dogs at sarcoptosis

2019 ◽  
pp. 48-53
Author(s):  
Susanna Dilyaverovna Kovalchuk
Keyword(s):  
Morphological Changes ◽  
Skin Lesions ◽  
Severe Form ◽  
Histological Structure ◽  
Epidermal Layer ◽  
Interstitial Edema ◽  
Histological Changes ◽  
Histological Studies ◽  
Severity Of The Disease

The results of histological studies of the skin of dogs with sarcoptosis are presented. Studies have shown that with different forms of sarcoptosis in dogs, histological changes occur in all layers of the epidermis and dermis, regardless of the location of ticks. The nature of these changes varies and depends on the severity of the disease. Depending on the form of the disease, similar pathomorphological changes of the skin severity were noted. We observed spongiosis, interstitial edema, hyperkeratosis of the epidermis, inflammatory and melanocytic infiltration of the epidermal layer of the skin. In the dermis, with deep skin lesions, necrosis foci and pronounced interstitial edema, mainly of the papillary layer, less often of the mesh layer, were detected. In generalized severe form in some areas of the dermis and epidermis completely lost histological structure.

scholarly journals Structure and functions of the types of Norway spruce (Picea abies[L.] Karst.) roots 

2012 ◽  
Vol 51 (No. 7) ◽  
pp. 305-311 ◽  
Author(s):  
R. Gebauer ◽  
M. Martinková
Keyword(s):  
Picea Abies ◽  
Norway Spruce ◽  
Fine Roots ◽  
Mechanical Load ◽  
Mutual Position ◽  
Histological Structure ◽  
Tree Roots ◽  
Herb Species ◽  
Structure And Functions ◽  
Forest District

The aim of the study was to describe variability of the structure of roots in Norway spruce (Picea abies [L.] Karst.) from their growth tips to the stem foot, i.e. anchor roots in relation to their changing functions. Histology and anatomy of plant organs were dealt with by the innumerable number of authors and fundamentals of knowledge in these disciplines have become the self-evident part of botany textbooks. The description of primary and secondary structure of roots is explained in many textbooks by means of drawings depicting the mutual position of particular systems of tissues. However, it refers mostly to the structure of herb roots in either Magnoliophytes or Liliophytes. Naturally, the structure of tree roots does not substantially differ from herb species. A certain problem is related to the secondary thickening of roots, their ramification, anastomosis and changes in the structure which are enforced by tension and pressure forces; these forces affect the roots during their mechanical load, e.g. by solifluction, soil load and compaction or through their above-ground systems. Trees can be stressed by wind gusts, snow cover, glazed frost and a number of other factors. Therefore, the structure of roots changes in the course of time as well as due to the increasing weight of the stem and crown. In terms of histological structure Norway spruce roots were studied within a forest stand in the area of the Křtiny Training Forest Enterprise, viz. Vranov Forest District (49°19´484´´N, 16°47´629´´E). Root systems were exposed with an air blast using the AIR-SPADE tool (nadezhdina, čermák 2003) and cuts of buttress roots, horizontal roots, root anastomosis and fine roots were selected. Histological studies were focused on manual transversal cuts of fine roots.

scholarly journals Histological Structure of the Thyroid Gland in Apolipoprotein E Deficient Female Mice After Levothyroxine Application

PRILOZI ◽  
2014 ◽  
Vol 35 (3) ◽  
pp. 135-140
Author(s):  
Irena Petrova ◽  
Elida Mitevska ◽  
Zorica Gerasimovska ◽  
Liljana Milenkova ◽  
Nevena Kostovska
Keyword(s):  
Thyroid Gland ◽  
Morphological Changes ◽  
Control Group ◽  
Histological Structure ◽  
Histological Characteristics ◽  
Peripheral Areas ◽  
Apoe Ko Mice ◽  
Morphometric Assessment ◽  
Experimental Group ◽  
Apoe Ko

AbstractThe aim of this study was to determine the histological characteristics of the thyroid gland in ApoE KO-/- mice following the application of levothyroxine (l-thyroxine).A total of 12 female ApoE KO-/- mice were divided into two groups. A control group of mice received distilled water and the experimental group received l-thyroxine dissolved in drinking water at a daily dose of 2 µg/ml, over 12 weeks. The paraffin sections were processed with the usual haematoxilin-eosin technique of staining.Qualitative histological analysis demonstrated: the presence of large distended follicles in the peripheral areas of the gland; fulfillment of the lumen of follicles with an ample amount of colloid; complete absence of resorptive vacuoles in the colloid; a flattened follicullar epithelium. Morphometric assessment showed a significant increase in the diameters of follicles in the peripheral areas of the gland and a significant decrease in the height of the follicullar epithelium (p <0,001).Our results demonstrated that l-thyroxine causes characteristic morphological changes in the structure of the thyroid gland in the direction of the occurrence of hyperthyroidism.

scholarly journals Gonadal Degeneration and Hepatopancreas Alteration in Orange Mud Crab Scylla olivacea Infected With Sacculina beauforti (Crustacea; Rhizocephala; Sacculinidae)

2020 ◽  
Vol 7 ◽  
Author(s):  
Hanafiah Fazhan ◽  
Khor Waiho ◽  
Henrik Glenner ◽  
Julia Hwei Zhong Moh ◽  
Marina Hassan ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Gonadosomatic Index ◽  
Carapace Width ◽  
Hepatosomatic Index ◽  
Mud Crab ◽  
Pathological Effect ◽  
Cell Structures ◽  
High Prevalence ◽  
Histological Characteristics ◽  
Males And Females

Infestation of Sacculina beauforti on an aquaculture species, mud crab Scylla olivacea is alarming due to its high prevalence and the extreme morphological changes in hosts. To further understand its pathological effect on growth and reproduction of S. olivacea, gonadal and hepatopancreatic histological changes of infected individuals were compared with healthy individuals. Also, the histological characteristics of S. beauforti's mature externa was described. Hepatopancreases of infected individuals were loosely packed and rootlets were observed in the intertubular spaces. Although hepatopancreatic tubule count was significantly lower, tubule diameters were unaffected. Gonads, however, were severely affected. No germ cells were found in the infected testes (except for remnants of spermatozoa), indicating the arrest of spermatogenesis. Rootlets were also present in testes of infected individuals. Ovarian tissues of infected females were severely damaged with no rigid cell structures. Gonadosomatic index (GSI) of infected males and females were lower, but the hepatosomatic index (HSI) were higher than their healthy counterparts. No significant differences in GSI and HSI values were observed among infected males and females. Multiple regression analysis revealed that carapace width, GSI and HSI are statistically important for the prediction of infection status. Given the high prevalence of S. beauforti infection and its disruptive effects on the morphology and internal physiology of S. olivacea, this study, albeit fundamental and incomprehensive, highlights to farmers and researchers the emergence of a castrating parasite and the urgency for the development of preventive measures and treatments for this disease in an economically important aquaculture species.

scholarly journals MORPHOLOGICAL CHANGES IN MICE LIVER IN DYNAMICS OF CONCANAVALIN A - INDUCED HEPATITIS

2015 ◽  
Vol 62 (1) ◽  
pp. 83-91
Author(s):  
S.I. Pavlovych ◽  
◽  
N.V. Makogon ◽  
N.G. Grushka ◽  
T.M. Bryzgina ◽  
...  
Keyword(s):  
Concanavalin A ◽  
Morphological Changes ◽  
Mice Liver

scholarly journals THE INTRODUCTION OF THE PHOTOSENSITIZER “FOTOLON” INTO THE COMMON BILE DUCT: INFLUENCE ON EXPERIMENTAL ANIMALS

2020 ◽  
Vol 4 (2) ◽  
pp. 189-195
Author(s):  
R. S. Shyla ◽  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Morphological Changes ◽  
Laboratory Data ◽  
Vital Signs ◽  
Physiological Solution ◽  
Control Group ◽  
Histological Structure ◽  
Experimental Animals ◽  
The Common

Background. Photodynamic therapy of liver diseases involves the introduction of photosensitizers into the common bile duct. Objective – to evaluate the effect on animals of under pressure introduction of the photosensitizer “Photolon” into the common bile duct. Material and methods. The control group was injected with physiological solution under pressure, the experimental one – with “Photolon”. The vital signs of the animals, the laboratory data were studied, a histological examination of the liver and duct was carried out. Results. The blood parameters of the experimental animals and their postoperative condition were not statistically different from those of the control group (p≤0.05). The liver and common bile duct had normal histological structure. Conclusions. The under pressure introduction of the photosensitizer “Photolon” into the common bile duct causes no morphological changes in the liver tissues and common bile duct and has no toxic effect on animals.

Histological Structure and Functions of Synovium1

2015 ◽  
pp. 1-26
Author(s):  
R. Bassleer ◽  
M.-P. Lhoest-Gauthier ◽  
A.-M. Renard ◽  
E. Heinen ◽  
G. Goessens
Keyword(s):  
Histological Structure ◽  
Structure And Functions

scholarly journals Prenatal development of the stomach in the goat (Capra hircus)

2021 ◽  
Vol 17 (1) ◽  
pp. 23-32
Author(s):  
Natalia Wojtasiak ◽  
Tomasz Stankiewicz
Keyword(s):  
Morphological Changes ◽  
Prenatal Development ◽  
Stomach Wall ◽  
Capra Hircus ◽  
Histological Structure ◽  
Prenatal Period ◽  
Practical Applications ◽  
Current State ◽  
Ultrasound Diagnostics ◽  
Characteristic Features

<b> During organogenesis in the developing goat embryo, a four-chamber stomach is formed from an extension of the primary intestine. Due to histological and morphological changes, each chamber of the stomach takes on characteristic features associated with its function. The histological structure of the stomach wall consists of four layers, the mucosa, submucosa, tunica muscularis and serosa. This work presents the current state of knowledge of the changes observed in each layer of the developing stomach and its morphogenesis in the prenatal period. Practical applications of this information in prenatal ultrasound diagnostics in goats are suggested as well. </b>

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