scholarly journals Multivariate analysis of inflammatory endotypes in recurrent nasal polyposis in a Chinese population

2018 ◽  
Vol 56 (3) ◽  
pp. 216-226 ◽  
Author(s):  
B. Wei ◽  
F. Liu ◽  
J. Zhang ◽  
Y. Liu ◽  
J. Du ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Chinese Population ◽  
Nasal Polyposis ◽  
Recurrent Nasal Polyposis

Adult Cystic Fibrosis Presenting with Nasal Polyposis and Chronic Sinusitis

1994 ◽  
Vol 8 (5) ◽  
pp. 237-240 ◽  
Author(s):  
Erica R. Thaler ◽  
Sean M. Smullen ◽  
David W. Kennedy
Keyword(s):  
Cystic Fibrosis ◽  
Nasal Polyposis ◽  
Chronic Sinusitis ◽  
Sweat Testing ◽  
General Aspects ◽  
Recurrent Nasal Polyposis

The diagnosis of cystic fibrosis is important to the otolaryngologist because of the association with chronic sinusitis and nasal polyposis. Eighty-five percent of patients are diagnosed under the age of 15, and diagnosis beyond age 20 is uncommon. We present two patients over 35 years of age in whom the diagnosis of cystic fibrosis was made during the course of workup and treatment for recurrent nasal polyposis and chronic sinusitis. To our knowledge, only one prior such case has been reported. This paper will provide a brief overview of the general aspects of the disease, discuss otolaryngic manifestations and management, and recommend indications for sweat testing in the adult.

Successful prevention of recurrent nasal polyposis by means of systemic low-dose IFN-[alpha ]2a

2001 ◽  
Vol 108 (1) ◽  
pp. 141-141 ◽  
Author(s):  
Margit A. Huber ◽  
Helmut Gall ◽  
Kerstin Geth[ouml ]ffer ◽  
Guido M[uuml ]hlmeier ◽  
Heinz Maier ◽  
...  
Keyword(s):  
Nasal Polyposis ◽  
Low Dose ◽  
Ifn Alpha ◽  
Successful Prevention ◽  
Recurrent Nasal Polyposis

Association Between TNF and TNF Receptor II Gene Polymorphisms and Acute Graft-Versus-Host Disease in Unrelated Donor Allogeneic Haematopoietic Stem Cell Transplantation within Chinese Population.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1158-1158
Author(s):  
Haowen Xiao ◽  
Xiaoyu Lai ◽  
Gongqiang Wu ◽  
Yi Luo ◽  
Jimin Shi ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Conditioning Regimen ◽  
Biological Factor ◽  
Haematopoietic Stem Cell ◽  
Unrelated Donor ◽  
Tnf Receptor ◽  
Donor Type ◽  
Grade Ii

Abstract Abstract 1158 Poster Board I-180 Background The importance of theTumor Necrosis Factor (TNF), including TNF-αa and TNF-β, in both the initial preconditioning and effector phases of aGVHD is well established. TNF and TNF receptor II (TNFRII) gene contains multiple single nucleotide polymorphisms (SNPs) in the promoter and transcription start site. There are conflicting datas regarding the cytokines gene polymorphisms and the risk of aGVHD in several studies and no data about Chinese population. This present study was designed to test association of TNFA, TNFB and TNFRII genotype for gene polymorphisms of both donors and recipients with incidence and severity of aGVHD in HLA-matched unrelated allo-HSCT within Chinese population. Methods A total of 138 unrelated donor/recipient pairs, who had undergone HLA-matched allo-HSCT from January 2001 to March 2009 at the First Affiliated Hospital of Zhejiang University School of Medicine, were tested for TNFA (TNFαa-857 C>T,TNFαa-863 C>A,TNFαa-1031 T>C), TNFB (TNFβ+252 A>G) and TNFRII (codon 196 T>G) polymorphism allele frequencies and genotype. SNPs were analyzed by Multiplex Snapshot. Results (1) The TNFαa-857 C/C genotype of the donor or recipient was significantly associated with a higher risk of aGVHD (for donor type:75.7% vs 41.9%, P=0.001; for recipient type: 72.7% vs 50.0%, P=0.039) and a higher incidence of grade II-IV aGVHD( for donor type:50.5% vs 19.4%, P=0.002; for recipient type:48.2% vs 25.0%, P=0.033). (2) The TNFβ+252*G allele of the donor or recipient was significantly associated with a higher incidence of aGVHD (for donor type:74.5% vs 46.9%, P=0.005; for recipient type: 75.0% vs 47.1%, P=0.005); (3) The TNFRII196 T/T genotype of the donor or recipient was significantly associated with a higher incidence of aGVHD (for donor type:73.7% vs 53.8%, P=0.028; for recipient type: 73.3% vs 58.3%, P=0.086); (4) TNF and TNFRII geng polymorphic features, together with other clinical and biological factor (patient's age, donor-recipient gender, diagnosis, conditioning regimen, transplant material and GVHD prophylaxis), were subjected to multivariate analysis for aGVHD manifestation in order to exclude indirect association of gene polymorphic features. In multivariate analysis, donor-recipient gender (female to male) (RR=1.602,95%CI: 1.035-2.479, P=0.034), the TNFαa-857 C/C genotype of donor (RR=2.177, 95%CI: 1.204-3.938, P=0.01) and the TNFβ+252*G allele of recipient (RR=1.920, 95%CI: 1.116-3.304, P=0.018) were found to significantly contribute to the development of aGVHD. The TNFαa-857C/C genotype of donor (RR=3.211, 95%CI: 1.373-7.509, P=0.007) and the TNFβ+252*G allele of recipient (RR=2.174, 95%CI: 1.063-4.443, P=0.033) were also associated with a higher incidence of grade II-IV aGVHD; (5) The genotypes of TNFαa-863 and TNFαa-1031 were not found to be associated with the risk of aGVHD. Conclusions These results, which is the first report of TNF and TNF receptor polymorphic features of Chinese population with the risk of aGVHD, suggest an interaction of the donor and recipient TNFαa-857, TNFβ+252 and TNFRII196 genotypes on risk of aGVHD. These results are helpful for predict allo-HSCT outcome, identify more suitable donors and clarify therapy on an individual patient basis. Disclosures No relevant conflicts of interest to declare.

Expression of Matrix Metalloproteinase-2 and -9 in Recurrent Nasal Polyposis

2011 ◽  
Vol 145 (2_suppl) ◽  
pp. P258-P259
Author(s):  
Ling-Feng Wang ◽  
Chen-Yu Chien ◽  
Chih-Feng Tai
Keyword(s):  
Matrix Metalloproteinase ◽  
Nasal Polyposis ◽  
Matrix Metalloproteinase 2 ◽  
Recurrent Nasal Polyposis

scholarly journals Sinonasal Plasmablastic Lymphoma Arising in the Setting of Recurrent Nasal Polyposis in an Immunocompetent Individual

2022 ◽  
pp. 014556132110708
Author(s):  
Marco DiBlasi ◽  
Christopher Jayne ◽  
Reilly McNamara ◽  
Catherine Iasiello ◽  
Daryl Colden
Keyword(s):  
Nasal Polyposis ◽  
B Cell Lymphoma ◽  
Sinonasal Tract ◽  
Plasmablastic Lymphoma ◽  
Sinus Surgery ◽  
Diagnostic Process ◽  
First Case ◽  
Sinonasal Mass ◽  
High Index Of Suspicion ◽  
Recurrent Nasal Polyposis

Plasmablastic lymphoma (PBL) is an aggressive, rare variant of B-cell lymphoma typically associated with human immunodeficiency virus and other immunocompromised populations. Most commonly found in the oral cavity, PBL can occasionally originate in the sinonasal tract. Diagnosis of PBL is difficult due to overlapping features with other malignancies; however, early detection and treatment are imperative given its aggressive clinical course. When in the sinonasal tract, the diagnostic process can be further complicated if the patient has a history of recurrent nasal polyposis. Described is the case of a 57-year-old immunocompetent male who initially presented with benign nasal polyposis, only to return a year after sinus surgery with a unilateral sinonasal mass consistent with PBL. As literature has yet to characterize this phenomenon, this article presents the first case reported of sinonasal PBL arising in the setting of recurrent nasal polyposis. This case emphasizes the importance of investigating sinonasal masses showing laterality, maintaining a high index of suspicion for malignancy, and keeping close surveillance of the patient after treatment of PBL.

Adult-onset Woakes’ syndrome: a rare entity

2021 ◽  
Vol 14 (1) ◽  
pp. e236894
Author(s):  
Pedro Salvador ◽  
Francisco Moreira da Silva ◽  
Rui Fonseca
Keyword(s):  
Ct Scan ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Sinus Surgery ◽  
Nasal Dorsum ◽  
Rare Entity ◽  
Adult Onset ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Nasal Pyramid ◽  
Recurrent Nasal Polyposis

Woakes’ syndrome (WS) is a rare entity, defined as severe recalcitrant nasal polyposis with consecutive deformity of the nasal pyramid. WS occurs mainly in childhood and its aetiology remains unclear. We report a case of a 68-year old woman, with aspirin-exacerbated respiratory disease, who presented with recurrent nasal polyposis and progressive broadening of the nasal dorsum. CT scan revealed extensive bilateral nasal polyposis and diffuse osteitis, with anterior ethmoidal calcified lesions. The patient underwent revision endoscopic sinus surgery and nasal pyramid deformity was successfully managed without osteotomies.

Acoustic rhinometry used as a method to monitor the effect of intramuscular injection of steroid in the treatment of nasal polyps

1991 ◽  
Vol 105 (3) ◽  
pp. 178-180 ◽  
Author(s):  
O. Elbrønd ◽  
J. U. Feeding ◽  
K. M. Gustavsen
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Peak Flow ◽  
Systemic Treatment ◽  
Acoustic Rhinometry ◽  
Self Assessment ◽  
Cross Sectional ◽  
Before And After ◽  
Recurrent Nasal Polyposis

AbstractAcoustic rhinometry is a new method which describes the geometry of the nasal cavity and the epipharynx. The method, based on the reflection of an acoustic signal entered into the nasal cavity, can be used to evaluate the cross-sectional area of the nasal cavity asa function of distance from the nostril. The method has, together with nasal expiratory peak flow (NPF) and nasal index based upon a self assessment score, been used to evaluate, in an objective and dynamic way, the effect of systemic treatment of nasal polyps with steroids in a series of eight patients with recurrent nasal polyposis. The study shows a significant relationship between these three parameters before and after systemic treatment of nasal polyps with steroids. It is concluded that in this study acoustic rhinometry had an accurate and objective method for measuring the geometry of the nasal cavity before and after treatment for processes which block the nasal cavity.

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