Transnasal Aerosol Delivery During High-Flow Nasal Cannula Therapy

2021 ◽  
Vol 67 (1) ◽  
pp. 149-150
Author(s):  
Jessica L Saunders ◽  
Michael D Davis
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula

scholarly journals Aerosol Delivery Through Adult High Flow Nasal Cannula With Heliox and Oxygen

2017 ◽  
Vol 62 (9) ◽  
pp. 1186-1192 ◽  
Author(s):  
Patricia A Dailey ◽  
Robert Harwood ◽  
Kyle Walsh ◽  
James B Fink ◽  
Tina Thayer ◽  
...  
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula

scholarly journals Aerosol Delivery Through an Adult High-Flow Nasal Cannula Circuit Using Low-Flow Oxygen

2019 ◽  
Vol 64 (4) ◽  
pp. 453-461 ◽  
Author(s):  
Yasmin M Madney ◽  
Maha Fathy ◽  
Ahmed A Elberry ◽  
Hoda Rabea ◽  
Mohamed EA Abdelrahim
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
Low Flow ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula

In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula

2011 ◽  
Vol 46 (8) ◽  
pp. 795-801 ◽  
Author(s):  
Arzu Ari ◽  
Robert Harwood ◽  
Meryl Sheard ◽  
Patricia Dailey ◽  
James B. Fink
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula ◽  
In Vitro Comparison

scholarly journals Mitigating Fugitive Aerosols during Aerosol Delivery via High-Flow Nasal Cannula Devices

2021 ◽  
pp. respcare.09589
Author(s):  
Jie Li ◽  
Amnah Alolaiwat ◽  
Lauren Harnois ◽  
James B. Fink ◽  
Rajiv Dhand
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula

scholarly journals Intermittent Aerosol Delivery to the Lungs During High-Flow Nasal Cannula Therapy

2014 ◽  
Vol 59 (10) ◽  
pp. 1476-1486 ◽  
Author(s):  
L. Golshahi ◽  
P. W. Longest ◽  
M. Azimi ◽  
A. Syed ◽  
M. Hindle
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula

scholarly journals Bronchodilator Delivery via High-Flow Nasal Cannula: A Randomized Controlled Trial to Compare the Effects of Gas Flows

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1655
Author(s):  
Jie Li ◽  
Yibing Chen ◽  
Stephan Ehrmann ◽  
Jie Wu ◽  
Lixin Xie ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Gas Flow ◽  
Controlled Trial ◽  
Inspiratory Flow ◽  
High Flow ◽  
Nasal Cannula ◽  
Saline Control ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula ◽  
Randomized Controlled

(1) Background: Aerosol delivery via high-flow nasal cannula (HFNC) has attracted increasing clinical interest. In vitro studies report that the ratio of HFNC gas flow to patient inspiratory flow (GF:IF) is a key factor in the efficiency of trans-nasal aerosol delivery. (2) Methods: In a randomized controlled trial, patients with a history of COPD or asthma and documented positive responses to inhaled bronchodilators in an outpatient pulmonary function laboratory were recruited. Subjects were randomized to receive inhalation at gas flow ratio settings of: GF:IF = 0.5, GF:IF = 1.0, or GF = 50 L/min. Subjects were assigned to inhale saline (control) followed by salbutamol via HFNC with cumulative doses of 0.5 mg, 1.5 mg, 3.5 mg, and 7.5 mg. Spirometry was performed at baseline and 10–12 min after each inhalation. (3) Results: 75 subjects (49 asthma and 26 COPD) demonstrating bronchodilator response were enrolled. Per the robust ATS/ERS criteria no difference was observed between flows, however using the criteria of post-bronchodilator forced expiratory volume in the first second (FEV1) reaching the screening post-bronchodilator FEV1 with salbutamol, a higher percentage of subjects receiving GF:IF = 0.5 met the criteria at a cumulative dose of 1.5 mg than those receiving GF:IF = 1.0, and GF = 50 L/min (64% vs. 29% vs. 27%, respectively, p = 0.011). Similarly at 3.5 mg (88% vs. 54% vs. 46%, respectively, p = 0.005). The effective dose at GF:IF = 0.5 was 1.5 mg while for GF = 50 L/min it was 3.5 mg. (4) Conclusions: During salbutamol delivery via HFNC, cumulative doses of 1.5 mg to 3.5 mg resulted in effective bronchodilation. Applying the robust ATS/ERS criteria no difference was observed between the flows, however using the more sensitive criteria of subjects reaching post screening FEV1 to salbutamol via HFNC, a higher number of subjects responded to the doses of 0.5 mg and 1.5 mg when HFNC gas flow was set at 50% of patient peak inspiratory flow.

Inhaled Bronchodilator Delivery via High-Flow Nasal Cannula for COPD and Asthma Patients: A Randomized Controlled Trial to Compare the Bronchodilation Effects of Gas Flow Rates

2020 ◽  
Author(s):  
Jie Li ◽  
Yibing Chen ◽  
Stephan Ehrmann ◽  
Jie Wu ◽  
Lixin Xie ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Effective Dose ◽  
Gas Flow ◽  
Controlled Trial ◽  
High Flow ◽  
Nasal Cannula ◽  
Aerosol Delivery ◽  
High Flow Nasal Cannula ◽  
Flow Rates ◽  
Randomized Controlled

Abstract BackgroundAerosol delivery via high-flow nasal cannula (HFNC) has attracted increasing clinician interest. In vitro studies report that the ratio of HFNC gas flow to patient inspiratory flow (GF:IF) is a key factor in the efficiency of trans-nasal aerosol delivery. This randomized controlled trial was aimed to validate this finding, and to explore the effective dose of inhaled bronchodilator to be given to patients via HFNC. Methods Patients with a history of COPD or asthma and documented positive response to inhaled bronchodilators in an outpatient pulmonary function laboratory were recruited. Subjects were randomized to receive inhalation at gas flow ratio/settings of : GF:IF=0.5, GF:IF=1.0, or GF=50L/min. Patients were assigned to inhale saline (control) followed by salbutamol via HFNC with an escalating dose sequence (0.5mg, 1.0mg, 2.0mg and 4.0mg). Spirometry was performed at baseline and after each inhalation. Results Seventy-five subjects (49 asthma and 26 COPD) demonstrating bronchodilator response (ATS/ERS) were enrolled. Using the criteria of post-bronchodilator FEV1 returning to screening post-bronchodilator FEV1 with salbutamol, a higher percentage of subjects receiving GF:IF=0.5 met criteria at cumulative dose of 1.5mg, than those receiving GF:IF=1.0, and GF=50L/min (64% vs 29% vs 27%, respectively, p=0.011). Similarly at 3.5mg (88% vs 54% vs 46%, respectively, p=0.005). The effective dose at GF:IF=0.5 was 1.5mg while for GF=50 L/min it was 3.5mg. Conclusion Dose response to salbutamol via HFNC was greater when administered with gas flow set at 50% of patient inspiratory flow, than with higher gas flow rates. Trial registration: www.clinicaltrials.gov: NCT03739359. Registered 13 November 2018, https://clinicaltrials.gov/ct2/show/NCT03739359?term=03739359&draw=2&rank=1

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