scholarly journals Respiratory Mechanics in a Cohort of Critically Ill Subjects With COVID-19 Infection

2021 ◽  
pp. respcare.09064
Author(s):  
August Longino ◽  
Toni Riveros ◽  
Erik Risa ◽  
Chris Hebert ◽  
Joshua Krieger ◽  
...  
2021 ◽  
pp. respcare.08319
Author(s):  
Siddique Chaudhary ◽  
Sadia Benzaquen ◽  
Jessica G. Woo ◽  
Jack Rubinstein ◽  
Atul Matta ◽  
...  

2001 ◽  
Vol 27 (9) ◽  
pp. 1487-1495 ◽  
Author(s):  
F. Ruiz-Ferrón ◽  
L. Rucabado Aguilar ◽  
S. Ruiz Navarro ◽  
R. Ramirez Puerta ◽  
S. Parra Alonso ◽  
...  

2018 ◽  
Vol 5 ◽  
Author(s):  
Kim M. G. Smeijsters ◽  
Ronald M. Bijkerk ◽  
Johannes M. A. Daniels ◽  
Peter M. van de Ven ◽  
Armand R. J. Girbes ◽  
...  

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Giacomo Grasselli ◽  
Emanuele Cattaneo ◽  
Gaetano Florio ◽  
Mariachiara Ippolito ◽  
Alberto Zanella ◽  
...  

Abstract Background The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechanics are currently scarce and the optimal setting of MV remains to be defined. This scoping review aims to provide an overview of available data about respiratory mechanics, gas exchange and MV settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps. Main text PubMed, EMBASE, and MEDLINE databases were searched from inception to October 30, 2020 for studies providing at least one ventilatory parameter collected within 24 h from the ICU admission. The quality of the studies was independently assessed using the Newcastle–Ottawa Quality Assessment Form for Cohort Studies. A total of 26 studies were included for a total of 14,075 patients. At ICU admission, positive end expiratory pressure (PEEP) values ranged from 9 to 16.5 cm of water (cmH2O), suggesting that high levels of PEEP were commonly used for setting MV for these patients. Patients with COVID-19 are severely hypoxemic at ICU admission and show a median ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) ranging from 102 to 198 mmHg. Static respiratory system compliance (Crs) values at ICU admission were highly heterogenous, ranging between 24 and 49 ml/cmH2O. Prone positioning and neuromuscular blocking agents were widely used, ranging from 17 to 81 and 22 to 88%, respectively; both rates were higher than previously reported in patients with “classical” acute respiratory distress syndrome (ARDS). Conclusions Available data show that, in mechanically ventilated patients with COVID-19, respiratory mechanics and MV settings within 24 h from ICU admission are heterogeneous but similar to those reported for “classical” ARDS. However, to date, complete data regarding mechanical properties of respiratory system, optimal setting of MV and the role of rescue treatments for refractory hypoxemia are still lacking in the medical literature.


2019 ◽  
Vol 32 ◽  
Author(s):  
Laryssa Marya Henrique Santos ◽  
Alita Paula Lopes de Novaes ◽  
Fabianne Maisa de Novaes Assis Dantas ◽  
Luana Carneiro Ribeiro ◽  
Célia Maria Machado Barbosa de Castro ◽  
...  

Abstract Introduction: The rehabilitation of critical patients usually occurs in the bed and is classified as low cardiovascular intensity. Therefore, it is essential to understand the physiological effects of these resources that we apply in clinical practice. Objective: Evaluate the acute effect of passive cycloergometry of lower limbs on respiratory mechanics and cardiovascular parameters in critically ill patients. Method: This was a labeled, randomized, controlled trial conducted in two intensive care units in the city of Recife, between August 2016 and May 2017. Patients were divided into two groups: (i) passive cycloergometry group (n = 16), where the patient performed a lower limb cycloergometry session for 20 minutes, and (ii) control group (n = 14), where the patient did not perform any therapeutic intervention, except during the application of the protocol. Cardiovascular parameters and respiratory mechanics were evaluated before, during and after their applicability. Results: No demographic differences were found between the two groups, showing the homogeneity between them. Regarding cardiovascular parameters, there were no differences between groups before, during and after the protocol. Regarding respiratory mechanics, there was a slight elevation of the resistance of the respiratory system in the cycloergometry group and a reduction of the same in the control group. Conclusion: The results suggest that passive cycloergometry applied to the critical patient did not promote significant cardiovascular changes and respiratory mechanics, being considered a safe and effective technique in clinical practice that can be applied without causing harm to patients under mechanical ventilation.


2001 ◽  
Vol 5 (1) ◽  
pp. A5-A5
Author(s):  
Keith Y.C. Goh ◽  
Wendy Teoh ◽  
Chumpon Chan

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