COVID-19 ARDS Is Characterized by Increased Dead Space Ventilation Compared With Non-COVID ARDS

2021 ◽  
pp. respcare.08786
Author(s):  
Michele Bertelli ◽  
Federica Fusina ◽  
Chiara Prezioso ◽  
Erika Cavallo ◽  
Niccolò Nencini ◽  
...  
Keyword(s):  
Dead Space ◽  
Dead Space Ventilation

scholarly journals Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gustavo A. Ospina-Tascón ◽  
Diego F. Bautista ◽  
Humberto J. Madriñán ◽  
Juan D. Valencia ◽  
William F. Bermúdez ◽  
...  
Keyword(s):  
Observational Study ◽  
Dead Space ◽  
Microcirculatory Dysfunction ◽  
Dead Space Ventilation

Increased Dead Space Ventilation Mediates Reduced Exercise Capacity in Systolic Heart Failure

2016 ◽  
Vol 193 (11) ◽  
pp. 1292-1300 ◽  
Author(s):  
Kirk Kee ◽  
Christopher Stuart-Andrews ◽  
Matthew J. Ellis ◽  
Jeremy P. Wrobel ◽  
Kris Nilsen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Capacity ◽  
Dead Space ◽  
Systolic Heart Failure ◽  
Dead Space Ventilation

scholarly journals Reductions in dead space ventilation with nasal high flow depend on physiological dead space volume: metabolic hood measurements during sleep in patients with COPD and controls

2018 ◽  
Vol 51 (5) ◽  
pp. 1702251 ◽  
Author(s):  
Paolo Biselli ◽  
Kathrin Fricke ◽  
Ludger Grote ◽  
Andrew T. Braun ◽  
Jason Kirkness ◽  
...  
Keyword(s):  
Respiratory Rate ◽  
Dead Space ◽  
Minute Ventilation ◽  
High Flow ◽  
Physiological Dead Space ◽  
Copd Patients ◽  
Dead Space Volume ◽  
Anatomical Dead Space ◽  
Dead Space Ventilation ◽  
Space Volume

Nasal high flow (NHF) reduces minute ventilation and ventilatory loads during sleep but the mechanisms are not clear. We hypothesised NHF reduces ventilation in proportion to physiological but not anatomical dead space.11 subjects (five controls and six chronic obstructive pulmonary disease (COPD) patients) underwent polysomnography with transcutaneous carbon dioxide (CO2) monitoring under a metabolic hood. During stable non-rapid eye movement stage 2 sleep, subjects received NHF (20 L·min−1) intermittently for periods of 5–10 min. We measured CO2 production and calculated dead space ventilation.Controls and COPD patients responded similarly to NHF. NHF reduced minute ventilation (from 5.6±0.4 to 4.8±0.4 L·min−1; p<0.05) and tidal volume (from 0.34±0.03 to 0.3±0.03 L; p<0.05) without a change in energy expenditure, transcutaneous CO2 or alveolar ventilation. There was a significant decrease in dead space ventilation (from 2.5±0.4 to 1.6±0.4 L·min−1; p<0.05), but not in respiratory rate. The reduction in dead space ventilation correlated with baseline physiological dead space fraction (r2=0.36; p<0.05), but not with respiratory rate or anatomical dead space volume.During sleep, NHF decreases minute ventilation due to an overall reduction in dead space ventilation in proportion to the extent of baseline physiological dead space fraction.

Use of the Ventilatory Equivalent to Separate Hypermetabolism from Increased Dead Space Ventilation in the Injured or Septic Patient

1980 ◽  
Vol 20 (2) ◽  
pp. 111-119 ◽  
Author(s):  
JOHN M. KINNEY ◽  
JEFFREY ASKANAZI ◽  
FRANK E. GUMP ◽  
ROBERT J. FOSTER ◽  
ALLEN I. HYMAN
Keyword(s):  
Septic Patient ◽  
Dead Space ◽  
Ventilatory Equivalent ◽  
Dead Space Ventilation

scholarly journals Dead Space Ventilation Parallels Changes in Scintigraphic Vascular Obstruction at Recurrence of Pulmonary Embolism and after Thrombolytic Therapy: A Case Report

1998 ◽  
Vol 5 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Marc A Rodger ◽  
Gwynne Jones ◽  
Francois Raymond ◽  
Daniel Lalonde ◽  
Mike Proulx ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Dead Space ◽  
Heparin Therapy ◽  
Alveolar Dead Space ◽  
Right Heart ◽  
Vascular Obstruction ◽  
Right Heart Dysfunction ◽  
Pulmonary Vascular Obstruction ◽  
Dead Space Ventilation

Physiological and alveolar dead space ventilation both increase in pulmonary embolism (PE) in proportion to the severity of vascular obstruction. The case of a patient with recurrent PE while on heparin therapy is presented. The recurrence was characterized clinically by severe pulmonary vascular obstruction and right heart dysfunction. The patient was treated with thrombolytic therapy, with excellent clinical and scintigraphic resolution. Dead space ventilation measurements at baseline, at the time of recurrence and after thrombolytic therapy are presented. The potential utility of dead space ventilation measurements for PE diagnosis and management are discussed.

scholarly journals Use of Non-Partitioned Ventilator Tubing Results in Dead-Space Ventilation Hypercarbia

2011 ◽  
Vol 56 (5) ◽  
pp. 698-701
Author(s):  
B. O. Asaad ◽  
M. Helwani ◽  
D. M. Wheeler ◽  
M. S. O'Connor
Keyword(s):  
Dead Space ◽  
Ventilator Tubing ◽  
Dead Space Ventilation
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